Mahatma Gandhi Medical College and Research Institute (MGMCRI) is a medical college and hospital located in the Bahour taluk of the union territory of Puducherry, India. The institute is run by the institution of Sri Balaji Educational and Charitable Public Trust (SBECPT) and founded by chairman, Shri M.K. Rajagopalan.The institution is recognized by the Medical Council of India, Ministry of Health and Family Welfare of the Government of India, and the Government of Puducherry. M.G.M.C.R.I was affiliated to Pondicherry University. M.G.M.C.R.I was recognized as a deemed university by university grants commission, New Delhi, on 4 August 2008.The campus is situated at Pillayarkuppam, 14 kilometres (8.7 mi) from the city of Pondicherry, near the town of Cuddalore. M.C.
Diabesity, defined as the coexistence of type 2 diabetes and obesity, is a major global driver of cardiovascular disease through mechanisms of chronic low-grade meta-inflammation. Recent advances in glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) have demonstrated benefits that extend beyond glycemic control to encompass immunometabolic modulation. The present narrative review aimed to synthesize evidence on the anti-inflammatory pathways and cardiovascular benefits of these agents, focusing on their mechanistic overlap, divergence and clinical implications. A systematic search of PubMed, Scopus, Web of Science and Google Scholar was conducted for articles published between 2010 and 2024. Approximately 350 articles were screened, and 129 were included based on relevance to inflammation, diabesity and cardiovascular outcomes, integrating data from mechanistic studies, imaging substudies and randomized controlled trials. Evidence suggests that GLP-1 RAs primarily attenuate inflammation through gut-brain-vascular signaling, endothelial transcriptional modulation, and macrophage polarization, whereas SGLT2is exert their effects via renal-hemodynamic reset, suppression of the NLRP3 inflammasome, and reduction of epicardial adipose tissue. Both classes consistently lower levels of systemic cytokines such as IL-6 and hsCRP and improve endothelial function, collectively mitigating cardiometabolic risk. However, major outcome trials were not designed with inflammation as a primary endpoint, and no head-to-head studies have directly compared these agents for inflammatory outcomes. Critical research gaps include the need for standardized biomarker panels, advanced imaging modalities, and evaluation of combination therapy. Future research should focus on precision medicine approaches incorporating phenotyping, biomarker stratification and long-term inflammation-focused trials to optimize personalized treatment strategies for patients with diabesity.
Abstract Background In spite of focused cardiopulmonary resuscitation (CPR) training, the in-hospital cardio-pulmonary resuscitation (CPR) performance often remains suboptimal, due to technical domain barriers and non-technical skill (NTS) barriers. We aimed to determine the technical domain and NTS barriers encountered by the in-hospital interprofessional (IP) CPR resuscitation teams through a cross-sectional, quantitative, analytical survey, and to determine whether a poor NTS score alone is associated with non-adherence to high-quality CPR. Methods A validated questionnaire was developed comprising 17 items on technical domain barriers and 9 on the NTS barrier domain. A web-based Likert-scale questionnaire was administered to assess perception-based barriers among 400 IP team members across healthcare settings in India, focusing on technical domain barriers and NTS domain barriers. IP members with at least 1 year of work experience, hands-on CPR training, and in-hospital CPR experience were recruited. Results There were 32.75% doctors, 29.75% nurses, 24% respiratory therapists, 10.25% emergency technicians, and 2.25% ICU technicians. The logistic regression analysis revealed that only five items independently predicted a poor technical domain score: inability to identify cardiac rhythm, non-working defibrillator, unavailability of a supraglottic airway device, unavailability of a correct-size laryngoscope blade, and a delay in loading medications. Five NTS items independently predicted a poor NTS score: lack of clear instructions from the team leader, lack of awareness of the dynamic nature of resuscitation, lack of closed-loop communication, lack of assigned tasks completed by a team member, and lack of knowledge sharing among team members. A poor NTS score is associated with perceived non-adherence to high-quality CPR (Chi-Square test, p-value < 0.001). Conclusion Both NTS barriers and technical domain barriers were associated with perceived non-adherence to high-quality CPR. Trial registration Clinical Trial Registry of India CTRI/2025/05/086727 registered on 13/05/2025.
Platelet-rich plasma (PRP) therapy enhances tissue healing and regeneration. A literature review assessed PRP applications in otorhinolaryngology. Eleven studies were identified—four in otology (tympanoplasty, hearing loss), three in rhinology (wound healing, epistaxis), and four in laryngology (vocal fold repair, post-surgical healing). PRP shows promise in improving surgical outcomes, warranting further research to establish standardized protocols and clinical efficacy.
Background: The health and well-being of nursing professionals are vital to the proper functioning of the healthcare system. Nurses face a stressful work environment, including rotating shifts, a heavy workload, and occupational stress, which may impair their nutritional status and health. Anemia, defined as a decrease in the concentration of hemoglobin in the blood, may cause weakness, fatigue, and decreased cognitive ability, which may impair work productivity. Objective: The study aimed to evaluate the prevalence of anemia among nursing personnel in a peripheral town in India and assess the demographic and occupational correlates of their hemoglobin levels. Methods: A cross-sectional study design was used to recruit 400 nursing personnel from various government and private healthcare institutions in the peripheral town. Ethical clearance was granted by the Institutional Ethics Committee (STH Ethics – IHEC 102-2023). A structured questionnaire was used to collect information on the demographic and work-related characteristics and the presence of comorbidities. Venous blood samples were collected and analyzed using an automated analyzer to measure the concentration of hemoglobin in the blood. Statistical analysis was performed using SPSS software version 21, and descriptive statistics and Pearson’s correlation were used to assess the associations between the variables. Results: The average age of participants was 30.4 years (SD: 9.8). The average hemoglobin level was recorded as 10.49 g/dL (SD: 1.75). Out of the total participants, 144 (36%) had hemoglobin levels below 10 g/dL. Moreover, 23 (5.8%) had severe anemia, i.e., below 8 g/dL. This shows a high incidence of anemia among nursing professionals. An independent ttest comparing hemoglobin levels between government and private nurses showed no significant difference (p > 0.05). Pearson correlation revealed a weak association between age and hemoglobin (r≈0.03, p > 0.05). A chi-square test assessing qualification and anemia prevalence was not significant (p > 0.05). Logistic regression also showed that age and workplace were not independent predictors of anemia in this cohort. Conclusion: Anemia is still a major health issue among nursing professionals, which might be related to work stress and lifestyle. It is strongly recommended that interventions be implemented for the health and well-being of nursing professionals. This is the first study in South India in the recent years
