Rosalind Franklin University of Medicine and Science (RFU) is a private graduate school in North Chicago, Illinois. It has more than 2,000 students in five schools: Chicago Medical School, College of Health Professions, College of Pharmacy, Dr. William M. Scholl College of Podiatric Medicine, and School of Graduate and Postdoctoral Studies. The university is named for famous DNA crystallographer Rosalind Franklin. Photo 51, an X-ray diffraction pattern of the B form of DNA, captured by Franklin in 1952, was pivotal in 20th-century history of biology. The image is depicted in the university's seal and logo.RFU offers more than 29 study programs in graduate health-related subjects, including PhD programs for medical and basic research. Its facilities include a new innovation and research building (opening fall 2019) designed to promote collaboration among academic and industry scientists and Helix 51, the first bioscience incubator in Lake County, Illinois. William M. William M.
We aim to evaluate the efficacy of risk-based surveillance strategies for hepatocellular carcinoma (HCC) in chronic hepatitis B virus (HBV) patients, addressing key questions: How can risk stratification enhance early detection? What are cost-effective approaches across diverse settings? How may novel diagnostic tools enhance surveillance? Recent studies highlight a persistent risk of HCC despite antiviral therapy, with reported annual incidences of 0.01–5.4
This study explores the relationship between immigrant status and awareness of family history of cancer (FHC) among various ethnic groups in the United States. Using data from the Health Information National Trends Survey (HINTS 5), a nationally representative cross-sectional survey of U.S. adults, Cycle 2 (2018), a population-based cross-sectional analysis was conducted among adults aged 18 years or older. Multivariable logistic regression analysis adjusted for sociodemographic factors such as gender, age, education level, and personal income. Overall, more than half of the participants were aware of their family history of cancer. After adjusting for sociodemographic factors, immigrants demonstrated high levels of FHC knowledge, except for non-Hispanic other immigrants (OR=0.55; 95% CI=0.30-0.98), whose awareness was relatively lower. Gender, education level, and income were significant predictors of FHC awareness, with women (OR=2,12; 95% CI=1.56-2.90), individuals with higher education levels (OR=2.34; 95% CI=1.33-4.13), and those with higher income (OR=1.83; 95% CI=1.12-2.99) more likely to be aware of their family cancer history. The study highlights the importance of addressing disparities in FHC awareness, especially among immigrant populations, to improve cancer screening and treatment outcomes. Efforts to promote family conversations about cancer history, particularly among men and specific ethnic groups, could mitigate these disparities and enhance cancer risk assessment and prevention strategies.
In this chapter we discuss electrophysiological approaches to the study of renal function. The purpose is to provide an overview of the available techniques, with particular emphasis on what can be learned using the latest methods. However, the chapter is neither a technical manual nor a comprehensive review of the literature. For this, we refer the reader to other sections of the book which deal with specific nephron segments and transport mechanisms. Finally, we will not derive mathematical equations from first principles. Those equations that are essential to the text are provided in the main body of the chapter, while the more detailed formulae are described in the appendices.
Oral Janus kinase inhibitors (JAKi) have proven effective in the treatment of atopic dermatitis (AD) in multiple clinical trials, providing rapid response, deep efficacy when given at the highest formulated dose, and in the case of abrocitinib and upadacitinib, superiority to biologics treatments in the first 4–16 weeks. However, it is unclear how this translates to real-world efficacy and safety. To assess the real-world effectiveness and safety of abrocitinib, baricitinib and upadacitinib in the treatment of AD. PubMed and EMBASE were systematically searched from inception until 3 January 2025 for observational studies investigating effectiveness and safety of abrocitinib, baricitinib and upadacitinib for the treatment of AD. The primary outcomes were the proportion of patients achieving a ≥ 75
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by pruritus, eczematous lesions, and impaired barrier function. Colloidal oatmeal is widely incorporated in over the counter moisturizers used as foundational therapy for AD, yet its clinical and barrier benefits have not been systematically evaluated. We conducted a systematic review and meta-analysis to assess the clinical efficacy and barrier effects of colloidal oatmeal containing formulations in AD. Following Preferred Reporting Items for Systematic Reviews and Meta- Analyses (PRISMA) guidelines, we searched PubMed, Embase, Cochrane Library, Scopus, CINAHL Complete, and ClinicalTrials.gov through August 2025 to identify clinical studies comparing colloidal oatmeal with non oat controls. Only data from two randomized controlled trials (combined n = 139) were available for pooled random effects meta-analysis (DerSimonian and Laird), and remaining studies were synthesized qualitatively. Pooled analysis of the two trials demonstrated equivalent improvement with colloidal oatmeal compared with a prescription barrier repair cream in reducing disease severity (Eczema Area and Severity Index, mean difference = − 0.16 [95
