University Hospital Center Dr Dragiša Mišović

Introduction: An emergency situation must not disturb the optimal growth and development of any child. Very important factors in preserving family health and the successful functioning of the family are the application of appropriate knowledge and skills, patience, humanity and continuous teamwork of parents and experts who deal with the early development of children. Objective: This research work is related to the improvement of the health care system for children by applying adequate measures of early intervention in an emergency situation. The goal is to determine the level of cooperation between health professionals and parents in pediatric practice. Methods: The research was conducted in 2020 at the KBC "Dr Dragiša Mišović - Dedinje". The sample included 122 parents of hospitalized children and 63 health workers and associates. The program SPSS (Statistical Package for Social Sciences) version 25.0 was applied, the measures of descriptive statistics, frequencies and percentages were used. Results:The results show that (95.1%) parents recognize the importance of their own involvement in the implementation of early interventions during emergency situations in cooperation with the health team, they (86.9%) are of the opinion that this way the health services will be of better quality. The opinion that the participation of parents in the application of early interventions is significant is held by (76.2%) health professionals, while (4.8%) believe that their participation is not desirable, almost one fifth is not sure. The employees of the pediatric departments included in the research are almost unanimous (95.2%) about the importance of applying RI in the health care of children, while they (85.7%) emphasize the harm of denying early interventions. Conclusion: The multidisciplinary cooperation of all actors who directly and indirectly deal with providing early interventions during an emergency situation is crucial for better quality of health services.

Introduction: The incidence of pulmonary carcinoids has increased in recent decades. Although most commonly diagnosed in adults, pulmonary carcinoids can also occur in children. Detection typically occurs through chest X-ray, with diagnosis confirmed by CT, bronchoscopy, and histopathological analysis. Surgery is the primary treatment, and before metastasis occurs, it is generally curative. Prognosis depends on the tumor type, disease stage, and presence of metastasis. Case outline: A 17-year-old adolescent was hospitalized for pneumonia. Following treatment, clinical improvement was observed, and a follow-up radiography showed regression of the changes. One month after discharge, the patient returned with progression of symptoms, leading to second hospitalization. Chest CT scan and bronchoscopy revealed a mass completely occluding the left main bronchus. Histological analysis of the biopsy confirmed a carcinoid tumor and left upper lobectomy was performed. Conclusion: Pulmonary carcinoid tumors present a challenge in clinical practice due to their nonspecific clinical course. Our case emphasizes the importance of a comprehensive diagnostic approach and early detection of the tumor, which is crucial for better prognosis.

Chamomile (Matricaria chamomilla L.) and feverfew (Tanacetum parthenium L. Sch. Bip.), both members of the Asteraceae family, are widely distributed in Serbia and traditionally used for their medicinal properties. Chamomile is primarily known for its gastrointestinal effects, while feverfew is noted for its antimigraine activity. Although the biological activity of each plant has been individually studied, there has been a lack of research related to their blends. So, the aim of this study was to prepare various chamomile/feverfew blends and their extracts with special focus on extraction temperature, to obtain superior herbal extract with the best functional characteristics. In order to characterize the obtained blend extracts this study included spectrophotometric and UHPLC Q-ToF MS analysis of prepared (selected) extracts, as well as evaluation of their antioxidant (ABTS, DPPH, FRAP, and CUPRAC) and antimicrobial properties. Antibacterial activity was evaluated against two Gram-positive and four Gram-negative bacterial strains using the broth microdilution method. Untargeted analysis showed the same phytochemical profile for both selected extracts (B3 and B9), as well as differences in distribution and abundance of identified compounds depending on applied extraction temperature (cold or heat-assisted). These differences in profile most probably contributed to variations in the antioxidant and antimicrobial properties of the extracts. The most potent antioxidant activity (123.04 µM TEAC/g) was observed for the 3:1 feverfew/chamomile blend (ABTS assay), while the highest metal-chelating capacity (1288.95 µM VCEAC/g) was recorded in extracts obtained by heat-assisted extraction (CUPRAC assay). Antibacterial activity of all blends ranged from 0.625 to 2.5 mg/mL, regardless of the extraction method. The findings indicate that combined extracts of chamomile and feverfew represent a promising source of bioactive compounds with potential applicability in both food science and pharmaceutical (biomedical) research.

Introduction Renal angiomyolipomas (AMLs) are neoplasms that can rarely rupture, causing hemorrhagic shock as the most serious complication. This pathological condition, (referring to AML) is classified as a benign tumor arising from the proliferation of epithelioid cells, consisting of fat tissue, blood vessels, and smooth muscle. Wunderlich syndrome describes a spontaneous, nontraumatic bleeding into the subcapsular or perirenal space. Most individuals with renal AML exhibit no symptoms and are often diagnosed incidentally, however, some may experience life-threatening complications such as rupture, hemorrhage, and circumstantial hypovolemic shock. Case outline Description of the clinical presentation of AML with rupture in a female patient with a brief overview of other cases of AML in the literature. Female patient, 68 years old, admitted for examination due to sudden severe pain in the abdomen with propagation to the right lumbar region accompanied by nausea and fatigue. After a complete physical examination, an abdominal ultrasound, and a CT scan, surgery was performed during which the right kidney was removed alongside the hematoma and the kidney envelopes, which were sent for pathohistological analysis. The result of the histopathological analysis confirmed that it was AML. Conclusion AMLs are benign neoplasms with potentially serious complications. The most serious complication of AML is rupture, leading to retroperitoneal hemorrhage, with tumor size being a significant risk factor. Considering the clinical importance of this potential complication, it is important to establish a swift and accurate radiological diagnosis, with the aim of timely therapeutic intervention and reduction of potential additional complications.