The University of Miami (informally referred to as UM, Miami, U of M, UMiami and The U) is a private research university in Coral Gables, Florida. As of 2020[update], the university enrolled 17,811 students in 12 colleges and schools across nearly 350 academic majors and programs, including the Leonard M. Miller School of Medicine in Miami's Health District, the law school on the main campus, and the Rosenstiel School of Marine and Atmospheric Science on Virginia Key with research facilities in southern Miami-Dade County.The University of Miami offers 138 undergraduate, 140 master's, and 67 doctoral degree programs. Since its founding in 1925, the university has attracted students from all 50 states and nearly 150 foreign countries. With 16,479 faculty and staff as of 2021, the University of Miami is the second largest employer in Miami-Dade County. The university's main campus in Coral Gables spans 240 acres (0.97 km2), has over 5,700,000 square feet (530,000 m2) of buildings, and is located 7 miles (11 km) south of downtown Miami, the core of the Miami metropolitan area, the nation's ninth largest and world's 34th largest metropolitan area with a population of 6.158 million people. University of Miami faculty include a sizable number of notable academics across nearly all disciplines, including four Nobel Prize winners. The university is classified among "Doctoral Universities: Very High Research Activity". The University of Miami's research expenditures in 2021 were $375 million, making it the 71st largest research university in the nation. Its undergraduate academic admissions standards are ranked the highest among Florida's 171 universities and colleges, and the university's library system ranks among the top 50 research libraries in North America with over four million volumes, including exceptional holdings in Cuban heritage and music.The University of Miami's intercollegiate athletic teams are collectively known as the Miami Hurricanes and compete in Division I of the National Collegiate Athletic Association. The University of Miami's football team has won five national championships since 1983 and its baseball team has won four national championships since 1982..
In 1960, Ghouila-Houri proved that every strongly connected directed graph G on n vertices with minimum degree at least n contains a directed Hamilton cycle. We asymptotically generalize this result by proving the following: every directed graph G on n vertices and with minimum degree at least (1+o(1))n contains every orientation of a Hamilton cycle, except for the directed Hamilton cycle in the case when G is not strongly connected. In fact, this minimum degree condition forces every orientation of a cycle in G of every possible length, other than perhaps the directed cycles.
Abstract Six-year interferometric synthetic aperture radar (InSAR) measurements of over 20 high-rise buildings in Sunny Isles, Florida, reveal persistent postconstruction settlements up to 5 cm. Supported by auger cast-in-place (ACIP) piles in a heterogeneous carbonate profile, these building-specific deformations cannot be attributed to regional subsidence or primary consolidation of the predominantly free-draining granular strata. Log-time and power-law models both reproduce the 6-year observations well and produce comparable 100-year extrapolations, with the power-law model yielding slightly more conservative estimates at long time horizons. Because both models fit the observational data equally well, the 100-year estimates are interpreted as scenario-based serviceability extrapolations rather than deterministic predictions. The inferred field-scale secondary compression indices exceed typical laboratory values for sands at the majority of sites, indicating that intrinsic granular creep alone cannot explain the observed deformations. Instead, the observations reflect a complex, system-level foundation–soil response involving carbonate stratigraphy, pile-group interaction, and progressive stress redistribution, the relative contributions of which cannot be quantified from the surface observations alone. To assist practitioners, the creep ratio R = A / s i is introduced, where A is the log-time settlement slope fitted to InSAR data and s i is the construction-stage settlement estimate. Used retrospectively, R quantifies whether past designs were conservative with respect to long-term creep; used prospectively, it provides a screening tool for new designs drawing on InSAR records from neighboring buildings. As InSAR monitoring becomes more widely available, this framework offers a path toward integrating satellite-based settlement observations into routine serviceability assessments for high-rise structures in coastal carbonate environments.
Intraosseous venous malformations are rare slow-flow vascular lesions in which involvement of lower-extremity long bones is uncommon. A 51-year-old woman with antithrombin III deficiency and post-thrombotic syndrome presented with focal left leg pain initially attributed to chronic venous disease. Computed tomography venography demonstrated a serpiginous intraosseous lesion within the distal fibula communicating with the peroneal venous system. Image-guided selective embolization was performed using foam sclerotherapy and n-butyl cyanoacrylate. Postprocedural imaging confirmed exclusion of the lesion. At follow-up, the patient reported resolution of focal bone pain without radiographic recurrence. This case illustrates diagnostic considerations and technical management of symptomatic lower-extremity intraosseous venous malformations.
Background Growing evidence suggests the experience of social exclusion is associated with increased risk for developing cardiovascular disease (CVD), however the psycho-neuro-immune mechanisms involved in this process remain unclear. Peripheral blood mononuclear cells (PBMCs) play an important role in the etiology of peripheral artery disease. Previous research has uncovered beta-adrenergic receptor inhibitory control (BARIC) of inflammation is blunted in PBMCs from individuals at greater risk for CVD. Furthermore, perceived social threat is shown to upregulate inflammatory processes in PBMCs. Given the excess burden of chronic inflammation and exposure to social ostracism reported in people living with HIV (PWH), the current study utilized an fMRI task paradigm to evaluate whether magnitude of blood oxygen level dependent (BOLD) response to social exclusion is associated with the time course of BARIC in CD16+ monocytes in relation to peripheral arterial stiffness. Methods BOLD response to the exclusion versus inclusion trials of a modified Cyberball task were measured in 25 PWH (50.8 ± 10.3 yrs) and 19 people living without HIV (PWoH) (52.8 ± 11.9 yrs.). CD16+ monocytes, collected 45 min before, 45 min and 90 min after Cyberball, were isolated using magnetic bead separation (StemCell™) and incubated for 18-hr following co-stimulation with lipopolysaccharide (LPS) and the non-selective beta-receptor agonist isoproterenol. BARIC was operationalized as the difference in TNF-α expressed by LPS-stimulated CD16+ monocytes without vs. with isoproterenol. A repeated measures ANCOVA assessed whether BOLD response to social exclusion in the subgenual anterior cingulate (sgACC), relates to change in BARIC of TNF-α following the encounter. The interactive effect of HIV+ status and BARIC on peripheral arterial stiffness was evaluated using multiple regression while controlling for age and gender. Results Whole-brain analysis revealed sgACC BOLD activation was significantly greater in the sgACC during exclusion compared to inclusion trials surviving FWE small-volume correction (p < 0.05, FWE-SVC). Compared to the middle and highest tercile, individuals within the lowest tercile of sgACC BOLD activation showed an initial BARIC response pre-task followed by a respective decline and recovery in BARIC immediate and 90 minutes post-task (F(1,32) = 5.471, p = .023, η2 = 0.152). Although these neuro-immune associations were not moderated by HIV status, greater BARIC was associated with lower arterial stiffness in PWoH and higher arterial stiffness in PWH (β = −0.89, t = −2.176, p = 0.040). Conclusion This study supports the role of sgACC in processing social exclusion and relevance of this biobehavioral response to the time course of beta-adrenergic receptor-mediated inhibitory control of TNF-α expression in intermediate and non-classical monocytes. Further this study provides preliminary evidence of a paradoxical association between greater BARIC of monocyte inflammation and arterial stiffness in PWH who have not yet developed CVD. Replication of these observations is warranted within a larger cohort to determine the contribution of these processes to the development of CVD.
Abstract This paper investigates the development of sustainable (ultra)high-performance concrete (UHPC) mixtures by replacing ordinary portland cement (OPC) with widely available materials, including portland limestone cement (PLC) and industrial by-products such as ultrafine limestone, fly ash, and slag, and by partially or fully replacing steel fibers with polyethylene fibers. Although UHPC is recognized for its excellent mechanical and durability performance, conventional mix designs remain cost-prohibitive and are not aligned with recent sustainability-driven changes in clinker and concrete production. This study addresses this gap by evaluating the fresh, mechanical, and flexural performance of PLC-based (ultra)high-performance concrete mixtures reinforced with steel, polyethylene, and hybrid steel–polyethylene fibers, and by comparing them with a commercially available UHPC. The mixtures are referred to as “(ultra)high” and not “ultrahigh” to reflect the targeted performance level under practical curing conditions because UHPC mixtures designed for such conditions may not always reach traditional UHPC strength thresholds. Mixtures with steel fibers exhibited flowability comparable to the commercial UHPC, while polyethylene fiber–reinforced mixtures showed reduced but still adequate flow for practical applications. A compressive strength of 120 MPa was achieved for a steel-fiber PLC-UHPC mixture under standard curing; however, mold material and specimen shape influenced the measured strength. Polyethylene fiber mixtures developed lower compressive strength but exhibited high flexural toughness, and the PLC-UHPC with hybrid fibers showed excellent flexural response but relatively lower compressive strength. A sustainability analysis indicated that the PLC-based mixtures can reduce the concrete carbon footprint relative to the commercial UHPC. The work aims to promote sustainable PLC-based UHPC as a practical solution toward more environmentally responsible and broadly deployable (ultra)high-performance concrete for infrastructure applications.
