AI agents may soon become capable of autonomously completing valuable, long-horizon tasks in diverse domains. Current benchmarks either do not measure real-world tasks, or are not sufficiently difficult to meaningfully measure frontier models. To this end, we present Terminal-Bench 2.0: a carefully curated hard benchmark composed of 89 tasks in computer terminal environments inspired by problems from real workflows. Each task features a unique environment, human-written solution, and comprehensive tests for verification. We show that frontier models and agents score less than 65% on the benchmark and conduct an error analysis to identify areas for model and agent improvement. We publish the dataset and evaluation harness to assist developers and researchers in future work at tbench.ai.
Characterizing the mechanisms and galaxy properties conducive to the escape of ionizing (LyC) emission is necessary to accurately model the Epoch of Reionization and identify the sources that powered it. Using Hubble Space Telescope data, the Ly α and Continuum Origins Survey (LaCOS) is the first program to obtain uniform, multiwavelength subkiloparsec imaging for a large sample (42) of galaxies observed in LyC and enable statistically robust studies between LyC and resolved galaxy properties. Here, we characterize the morphology and galaxy merger properties of LaCOS galaxies and investigate their connection with the escape fraction of LyC emission f esc LyC . We find strong anticorrelations between f esc LyC and size ( r 20 , r 50 , and r 80 ) measured in filters containing emission from star-forming regions, and with the asymmetry and clumpiness in F150LP, a filter tracing UV continuum and Ly α . We find that ≥48% of LaCOS galaxies, and ≥41% of LaCOS LyC-emitters are visually classified as galaxy mergers. Galaxies robustly identified as mergers in LaCOS are at advanced stages of interaction, close to coalescence. The f esc LyC properties of robust mergers and low-probability mergers cannot be differentiated statistically, and we only find significant difference between the two populations in terms of their sizes and LyC luminosity: robust mergers having larger values. We conclude that (i) f esc LyC tends to be larger in galaxies with a small number of compact, centrally located, UV-emitting star-forming regions, (ii) mergers at advanced stages of interaction represent a sizable fraction of LyC-emitting samples at z ∼ 0.3, and (iii) mergers can facilitate the escape of LyC photons from galaxies.
The prognosis for patients with bladder cancer (BCa) with lymph node (LN) metastasis is poor, and it is not improved by current treatments. Long noncoding RNAs (lncRNAs) are involved in the pathology of various tumors, including BCa. However, the role of Differentiation antagonizing non-protein coding RNA (DANCR) in BCa LN metastasis remains unclear. In this study, we discover that DANCR was significantly upregulated in BCa tissues and cases with LN metastasis. DANCR expression was positively correlated with LN metastasis status, tumor stage, histological grade, and poor patient prognosis. Functional assays demonstrated that DANCR promoted BCa cell migration, invasion, and proliferation in vitro and enhanced tumor LN metastasis and growth in vivo. Mechanistic investigations revealed that DANCR activated IL-11-STAT3 signaling and increased cyclin D1 and PLAU expression via guiding leucine-rich pentatricopeptide repeat containing (LRPPRC) to stabilize mRNA. Moreover, oncogenesis facilitated by DANCR was attenuated by anti-IL-11 antibody or a STAT3 inhibitor (BP-1-102). In conclusion, our findings indicate that DANCR induces BCa LN metastasis and proliferation via an LRPPRC-mediated mRNA stabilization mechanism. DANCR may serve as a multi-potency target for clinical intervention in LN-metastatic BCa.
This chapter presents a moving spotlight theory that provides truthmakers for every truth about how things were or will be. On the view defended, past, present, and future beings are all real, but the only way any thing is is the way it is now. It is argued that things have temporal distributional properties that describe their intrinsic history over time, and hence that the way things are now settles how they were and will be. It is argued that acceptance of the B-Theory requires accepting a temporal parts theory of persistence, and hence that endurantism requires the A-Theory, and in particular an A-Theory that accepts that the only way things are is the way they are now.
Expectations for corporate directors have expanded over time, placing growing demands on their time and attention. Drawing on the cognitive foundations of the attention-based view (ABV), we theorize that board directors' leadership roles and committee assignments shape their attentional perspective and engagement in ways that can both hinder and enhance governance effectiveness. Using a panel dataset of 39,610 board-committee-year observations from over 3000 US boards between 1999 and 2023, we examine how directors' roles and responsibilities relate to governance outcomes associated with boards' audit, compensation, and nomination committees. We find that holding more board-leadership roles and board-committee assignments may impose cognitive burdens that undermine governance effectiveness, whereas holding more-diversified committee assignments may enhance governance by enabling directors to sequence their attention more strategically across governance tasks. This examination thus advances our theoretical understanding of how attention functions when distributed across multiple organizations simultaneously. In addition, by moving beyond simple counts of board directorships to explicitly consider the number and configuration of directors' leadership roles and committee responsibilities, this study advances the literature on governance effectiveness and board design. In doing so, we highlight the value of committee-level analysis for understanding board dynamics and governance.
