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Promoting digital governance is a key direction for the Chinese government's governance reform. Based on panel data from 280 prefecture-level and above cities spanning 2008-2023, this study treats the "National Pilot Policy for Information Benefiting the People" as a quasi-natural experiment. Employing a difference-in-differences model, it examines the impact of government digital governance on urban innovation and its underlying mechanisms. Findings indicate that digital governance significantly enhances urban innovation, with conclusions remaining robust after rigorous stability tests and endogeneity treatments. Mechanism tests reveal that digital governance enhances urban innovation by cultivating innovation entities, improving the innovation environment, and optimizing the allocation of innovation elements. Further analysis indicates that the impact of digital governance on urban innovation is influenced by city location and development level. In eastern regions, areas with lower government fiscal pressure, and regions with higher levels of informatization, government digital transformation is more effective in boosting urban innovation. In addition, digital governance has significantly promoted sustainable and strategic innovation in cities and can influence innovation in neighboring areas through spillover effects. These findings can provide valuable insights for promoting urban innovation.
A newly identified specific category of non-coding RNA (ncRNA), circRNAs, is drawing interest for their role in controlling several biological processes including muscle regeneration, aging, and adaptation to physical activity. Unlike linear RNAs, circRNAs are very stable and can have long-lasting regulatory impact since they create a covalently closed loop structure. Emerging evidence indicates that circRNAs play a pivotal role in skeletal muscle biology by regulating myogenesis, satellite cell activation, protein synthesis, and cellular senescence—processes significantly influenced by aging. These molecules are crucial for muscle function and regeneration, acting as microRNA sponges, interacting with RNA-binding proteins, and modulating gene expression and translation. Exercise—especially resistance and endurance training—has been shown to change circRNA expression in skeletal muscle, therefore possibly reducing age-related muscle loss and improving regenerative capacity. Though encouraging, much of the circRNA in muscle biology research is still in its early stages, with few functional studies and varying outcomes across various species and exercise models. Moreover, the exact ways circRNAs affect muscular adaptation to exercise and stop aging-related degeneration are still not completely known. This review addresses the existing knowledge gaps regarding the potential therapeutic applications of circRNAs in combating muscle degeneration and sarcopenia, as well as their role in muscle health and aging.
