The aim of this study was to evaluate serum Prestin and Ribeye (CtBP2) levels in children with bilateral congenital profound sensorineural hearing loss (SNHL) and to investigate their potential as circulating biomarkers of cochlear pathology. A case-control study was conducted at a tertiary referral otorhinolaryngology center. A total of 153 children aged 1–6 years were included, comprising 75 children with bilateral congenital profound SNHL and 78 normal-hearing controls. Serum Prestin and Ribeye concentrations were measured in peripheral blood samples using enzyme-linked immunosorbent assay (ELISA). Diagnostic performance was assessed using receiver operating characteristic (ROC) analysis, and associations with hearing loss status were evaluated using multivariate analysis of covariance (MANCOVA) and logistic regression analysis. Serum Prestin and Ribeye levels were significantly higher in children with congenital profound SNHL than in normal-hearing controls (median Prestin: 930.70 vs. 414.08 pg/mL, p = 0.001; median Ribeye: 15.49 vs. 6.26 ng/mL, p < 0.001). After simultaneous adjustment for age and sex using MANCOVA, the overall biomarker profile remained significantly associated with hearing status (Wilks’ λ = 0.865, p < 0.001). In ROC analysis, Ribeye demonstrated greater discriminatory performance for SNHL than Prestin (area under the curve [AUC], 0.76 vs. 0.65). Logistic regression analysis showed that each 1-unit increase in serum Ribeye level was associated with an 18
Hereditary haemorrhagic telangiectasia (HHT) is frequently associated with recurrent epistaxis, causing morbidity and impaired quality of life. Data on operating room-based endonasal polidocanol sclerotherapy remain limited. This study aimed to assess the effectiveness, safety, patient acceptance, and procedural feasibility of this approach for HHT-related epistaxis. A retrospective observational study was conducted in a tertiary referral centre including 20 adults with HHT treated with endonasal polidocanol sclerotherapy between March 2022 and December 2025. Clinical variables, visceral arteriovenous malformation (AVM) involvement, procedure-related variables, complications, and patient-reported outcomes were analysed. A total of 59 procedures were performed. Mean weekly epistaxis frequency decreased from 8.3 to 2.35 episodes per week (p < 0.001), with a mean relative reduction of 68.1
This study aimed to identify risk factors for prolonged hospital length of stay (LOS) following head and neck cancer (HNC) surgery, evaluate its oncologic impact, and identify clinically actionable targets to reduce LOS. We retrospectively reviewed a 10-year cohort of HNC patients treated surgically at a tertiary referral center (2013–2022). Prolonged LOS was defined as hospitalization exceeding the 95th percentile (> 24 days) and extremely prolonged LOS as exceeding the 99th percentile (> 73 days); patients with a mean LOS of 10 days served as controls. Risk factors were assessed using multivariable logistic regression, and quantile regression and network analyses evaluated the relative importance and interrelationships of postoperative complications. Of 365 patients, 44 had extremely prolonged LOS, 182 had prolonged LOS, and 139 were controls. Prolonged LOS was associated with more complications and poorer oncologic outcomes, including higher recurrence and disease-specific mortality. Laryngeal/hypopharyngeal subsite (odds ratio [OR], 4.95, 95
To highlight the presentation, management, and functional outcomes of subjects with acute laryngotracheal trauma, managed by a dedicated laryngology unit in a tertiary care hospital in South India. A retrospective review of the medical records of acute laryngotracheal trauma cases from 1st January 2014 to 31st August 2023 was carried out. Data collected included demographics, mechanism of trauma, age, and sex, presentation, time of injury to intervention, investigations, Schaefer-Fuhrman (SF) grade, management (airway access, surgical techniques conservative methods) and outcomes. Complications (via a graded complication classification grouped into mild, moderate , severe), functional airway, voice and swallowing outcomes were analysed separately as well as at the end of one year follow up. Sixty-eight subjects (57 males and 11 females) with laryngotracheal trauma were managed during this study period. All but 2 subjects received definitive management within 48 hours of the trauma. 91.2
