The article presents the results obtained on 20 patients treated with lower than usual doses of norgestrel and ethinyl estradiol. Patients were between 18-41 most were married with children and 80% had never used contraception. A complete gynecological examination was done before starting administration of oral contraceptives (OCs) including cytological pathological and hormonal studies. There were no pregnancies no edemas and no modification of blood pressure. Side effects were very minor and included nausea mastodynia and occasional spotting. There was no modification of the menstrual cycle and dysmenorrhea disappeared in 30% of cases. Colpocytogram and endometrial biopsies were normal. These results which coincide with others presented by different authors show that reduced doses of estropregestational agents can have good therapeutic effect while lowering the incidence of serious side effects.
A clinical investigation of L-Dopa on idiopathic oligozoospermia is carried out. Thirty nine male oligozoospermic patients with primary sterility were divided in two groups. The first group of 25 patients was treated with 500 mg a day during two months. The second group of 14 patients received 750 mg a day for the same time. In the first group we find 14 improvements, 9 at the first month and 5 at the second month. In the second group 8 improvements were observed, 5 in the first month and 3 in the second months. It would seem that L-Dopa has a stimulatory effect on spermatogenesis possibly through hypophysis when it is administered at these dosis and for these periods of time, and it was also observed similar results for longer terms of treatment.
76 adolescents younger than 18 and with an active sexual life were observed to study the tolerance and side effects of various types of contraceptive agents: 69 were administered combined agents 6 sequential agents and 1 the mini pill. The patients were followed up after suspension of administration for a period of 6 months to 3 years. 82.89% of them tolerated the drug very well; side effects were very minor and similar to those in adult women. 65.69% stopped taking the pill to become pregnant there were no unwanted pregnancies and in all cases the contraceptive agent had a positive influence on the menstrual cycle. Soon after suspension of the pill 82.5% of girls became pregnant and 17.50% did not even after 6-12 months after interruption. Given the results there are no reasons why oral contraceptives should not be administered to adolescents the same way they are administered to women.
36 patients on D-Norgestrel and 5 controls were investigated to study the action of the drug on the diesterase enzyme secreted by the endometrium and which is responsible for the functional and structural changes on which the motility and fertilizing power of spermatozoa depends. D-Norgestrel was administered either postcoitally or in continuous minidoses and the endometrial liquid was gathered and examined 5 times. There were no significant enzymatic changes in the first 2 hours after ingestion of the drug; from the 3rd to the 7th hour a decrease in enzymatic values was noted. The absence of enzymatic activity in 80% of cases studied could be the fundamental cause for the decrease in spermatic activity and the principal mechanism for the contraceptive action of D-Norgestrel.
114 healthy and fertile patients were treated with a combination of 150 mcg of D-Norgestrel and 30 mcg of ethinyl estradiol for a total of 1164 cycles. The treatment established a regular menstrual cycle for all patients with a duration of 28.5 days and a bleeding period of 3-5 days. A small percentage of patients 3.4% complained of spotting and an even smaller percentage of breakthrough bleeding. There were 3 pregnancies due to the fact that treatment had been erroneously suspended for a few days. Side effects were minimal mainly headache and slight increase in body weight. Blood pressure was normal and so were triglycerides and cholesterol levels. (Summary in ENG)
