1 はじめに 本稿は平成22年12月に開催された名古屋市立 大学医学会総会での講演を簡潔にレビューした ものです.脂肪酸の体内動態解析には高速液体 クロマトグラフィーと質量分析法を用いた定量 法(HPLC/MS)が不可欠であるので今回はこ れについても若干のデータと共に述べます.本 研究は北海道大学水産科学研究院板橋豊教授と の共同研究を含みます. DAGは天然植物油中に数パーセントの割合 で含有されている.DAGはグリセロールを基 本骨格とし高級脂肪酸がエステル結合してい る.構造中の-CO-R 原子団(Rは高級脂肪酸を 表す)をアシル基と呼ぶためアシルグリセロー ルと言う.DAGにはグロセロールの1位と2 位あるいは1位と3位の炭素にエステル結合が 存在するので構造的に1,2-DAGと1,3-DAGが ある(図1).これらは自然界ではそれぞれ3: Nagoya Med. J. (2011)51,197―201
Object. Postoperative hearing loss is the most serious complication of microvascular decompression for facial spasm and trigeminal neuralgia. To test the usefulness of brainstem auditory evoked potential(BAEP)as a intraoperative monitoring, in relation to hearing loss we compared BAEP records and postoperative hearing. We also compared BAEP data during microvascular decompression to that obtained during acoustic tumor surgery. Methods. BAEP was monitored every5to10minutes with a loudness of100dB and75Hz per second of frequency. 15cases of trigeminal neuralgia and10cases of facial spasm were monitored during microvascular decompression. 8cases of acoustic tumor were monitored intraoperatively with BAEP using the same method used with microvascular decompression and the results were compared. Results. Mean delay of the Vth wave latency was1.16msec for facial spasm and1.15msec for trigeminal neuralgia. Both were significantly longer than the delay found in acoustic tumor removal, in which hearing was preserved postoperatively. However, hearing disturbance was found in two cases of facial spasm, one severe case of hearing loss and another mild hearing impairment. No hearing impairment was seen in trigeminal neuralgia cases. Conclusions. Delay of Vth wave latency occurred equally in surgery for facial spasm and trigeminal neuralgia, yet hearing disturbance was found only in surgery for facial spasm. Delay of BAEP may be caused by the retraction of the cochlear nerve, but hearing disturbance might be caused by direct manipulation injury including inflammation and microcirculatory impairment to the cochlear nerve which may occur in surgery for facial spasm and may not be detected by intraoperative BAEP monitoring.
