Open lung biopsy is performed in patients with congenital heart disease to determine the suitability for surgical correction. Controversy exists as to whether arterial density can be graded with certainty. We studied the influence on the grading (Heath-Edwards) of two morphometric techniques. Lung tissue from 14 controls and biopsy specimens from 80 patients with atrial septal defect (n=10) ventricular septal defect (n=27), complete atrioventricular canal (n=27), miscellaneous lesions (n=8) and tetralogy of Fallot (n=8) were analyzed with a planimetric method. Additionally, wall thickness was determined in 52 patients by distance measurements. The ratio of alveoli/arteries per area of lung tissue was measured. Medial thickness was "increased" on distance measurements in 15% of the cases where planimetric data showed normal wall thickness. The ratio of alveoli/arteries varied up to 43% from the mean. Hemodynamic data obtained at a median (range) time of 2 months (1 day to 18 months) before the operation did not correlate with morphologic findings. In 27 patients hemodynamic data were recorded at a median time of 1 year (3 days to 44 months) after the operation. Intimal fibrosis occupying more than 10% of the vessel lumen was associated with persistent high pulmonary vascular resistance. We conclude that morphometric techniques are useful to determine the degree of fibrosis in advanced vascular lesions. Arterial density cannot be determined in biopsy specimens with adequate certainty.
Research Articles| October 01 2008 Sepsis/Septic Shock in Adults and Children Subject Area: Immunology and Allergy , Pathology and Cell Biology Robert W. Pryor; Robert W. Pryor Oklahoma Medical Research Foundation and University of Oklahoma Health Sciences Center, Oklahoma City, Okla.; Humana Hospital-Medical City, Dallas, Tex., USA Search for other works by this author on: This Site PubMed Google Scholar Lerner B. Hinshaw Lerner B. Hinshaw Oklahoma Medical Research Foundation and University of Oklahoma Health Sciences Center, Oklahoma City, Okla.; Humana Hospital-Medical City, Dallas, Tex., USA Search for other works by this author on: This Site PubMed Google Scholar Survey and Synthesis of Pathology Research (1989) 8 (5-6): 222–230. https://doi.org/10.1159/000157153 Article history Published Online: October 01 2008 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Robert W. Pryor, Lerner B. Hinshaw; Sepsis/Septic Shock in Adults and Children. Survey and Synthesis of Pathology Research 31 December 1989; 8 (5-6): 222–230. https://doi.org/10.1159/000157153 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsSurvey and Synthesis of Pathology Research Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1989Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Other Types| October 01 2008 The Role of Endothelium in Leukocytes Emigration: The Views of Cohnheim, Metchnikoff and Their Contemporaries Subject Area: Immunology and Allergy , Pathology and Cell Biology Henry Z. Movat Henry Z. Movat Departments of Pathology and of Immunology, University of Toronto, Medical Sciences Building, Toronto, Ont., Canada Search for other works by this author on: This Site PubMed Google Scholar Pathology and Immunopathology Research (1989) 8 (1): 35–41. https://doi.org/10.1159/000157136 Article history Published Online: October 01 2008 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Henry Z. Movat; The Role of Endothelium in Leukocytes Emigration: The Views of Cohnheim, Metchnikoff and Their Contemporaries. Pathology and Immunopathology Research 1 January 1989; 8 (1): 35–41. https://doi.org/10.1159/000157136 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsSurvey and Synthesis of Pathology Research Search Advanced Search This content is only available via PDF. 1989Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Review Articles| October 01 2008 Ontogenic Development of the Secretory Immune System in Human Fetal Salivary Glands Subject Area: Immunology and Allergy , Pathology and Cell Biology Yoshio Hayashi; Yoshio Hayashi Department of Pathology, Tokyo Metropolitan Institute of Gerontology, and Department of Pathology, Japan Red Cross Medical Center, Tokyo, Japan Search for other works by this author on: This Site PubMed Google Scholar Chieri Kurashima; Chieri Kurashima Department of Pathology, Tokyo Metropolitan Institute of Gerontology, and Department of Pathology, Japan Red Cross Medical Center, Tokyo, Japan Search for other works by this author on: This Site PubMed Google Scholar Tamiko Takemura; Tamiko Takemura Department of Pathology, Tokyo Metropolitan Institute of Gerontology, and Department of Pathology, Japan Red Cross Medical Center, Tokyo, Japan Search for other works by this author on: This Site PubMed Google Scholar Katsuiku Hirokawa Katsuiku Hirokawa Department of Pathology, Tokyo Metropolitan Institute of Gerontology, and Department of Pathology, Japan Red Cross Medical Center, Tokyo, Japan Search for other works by this author on: This Site PubMed Google Scholar Survey and Synthesis of Pathology Research (1989) 8 (5-6): 314–320. https://doi.org/10.1159/000157159 Article history Published Online: October 01 2008 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Yoshio Hayashi, Chieri Kurashima, Tamiko Takemura, Katsuiku Hirokawa; Ontogenic Development of the Secretory Immune System in Human Fetal Salivary Glands. Survey and Synthesis of Pathology Research 31 December 1989; 8 (5-6): 314–320. https://doi.org/10.1159/000157159 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsSurvey and Synthesis of Pathology Research Search Advanced Search This content is only available via PDF. 1989Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Research Articles| October 01 2008 Pathogenesis of Chlamydial Infections Subject Area: Immunology and Allergy , Pathology and Cell Biology Julius Schachter Julius Schachter Department of Laboratory Medicine, University of California, San Francisco, Calif., USA Search for other works by this author on: This Site PubMed Google Scholar Survey and Synthesis of Pathology Research (1989) 8 (3-4): 206–220. https://doi.org/10.1159/000157149 Article history Published Online: October 01 2008 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Julius Schachter; Pathogenesis of Chlamydial Infections. Survey and Synthesis of Pathology Research 31 December 1989; 8 (3-4): 206–220. https://doi.org/10.1159/000157149 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsSurvey and Synthesis of Pathology Research Search Advanced Search Article PDF first page preview Close Modal 1989Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
We employed a purified mammalian (fetal calf) acetylcholine receptor (AChR) preparation to compare proliferation of peripheral blood mononuclear cells (PBMC) of patients with myasthenia gravis (MG) (n = 8) and normal controls (n = 6). PBMC of patients with MG demonstrated an enhanced proliferative response to AChR when compared to controls (mean stimulation index (SI) of 4.2 +/- 1.5 (SD) vs. 1.1 +/- 0.6; p less than 0.01) but no difference in the response to tetanus toxoid (7.1 +/- 3.9 vs. 11.1 +/- 10.8). These results suggest that MG patients exhibit a presumptive T-cell response to purified mammalian AChR that is not found in normal subjects. The nature of the proliferating cell and the interaction with B cells producing anti-AChR antibodies remain to be determined.
Focused preclinical studies have been used to gain insight into the mechanism of therapeutic activity of cytokines, growth factors and biological response modifiers (BRMs). These data can then be used to develop a clinical hypothesis to facilitate the development of these new biological drugs. In this manuscript, we discuss a number of preclinical and clinical studies using interferon-gamma, IL-2, and the colony stimulating factors. The importance of the systematic profiling of the biological activity of such biological drugs is emphasized and we discuss the utility of the mechanistic data in their clinical development. The overall preclinical approach identifies the cellular, biochemical or gene regulatory event that is associated with the therapeutic activity of a biologic and this surrogate (be it biological, chemical, or quality of life) is then used to optimize the clinical protocol in a phase 1b trial. This, in theory, results in the rapid identification of the optimal dose, schedule and route of administration for subsequent testing in a phase II/III clinical trial.
Our calculation provides the first population-based incidence rate of childhood mesothelioma in the United States. Based on these data and on our pathology review, we conclude that mesothelioma occurs rarely in children and that this diagnosis is difficult to establish. A more systematic approach to identifying mesothelioma cases in children, as well as adults, will be facilitated by increasing state surveillance of cancer incidence and by the proposed addition of a unique code for mesothelioma in the Tenth Revision of the ICD. There is a critical need for histopathological verification of mesothelioma cases. The increased use of a uniform, reproducible histopathologic classification and mesothelioma panels should address this problem. A thorough microscopic study of individual cases needs to be supplemented by a careful assessment of the clinical findings and environmental factors. The available data thus far do not support an association between childhood mesothelioma and asbestos exposure. However, the ubiquitous nature of asbestos exposures, the known association of asbestos with adult mesothelioma, the unreliability of the diagnosis, and the lack of adequate data regarding asbestos exposures, all indicate that asbestos involvement cannot be categorically ruled out, especially in older children with the potential for a longer duration of exposure and a plausible induction period. Mesothelioma in children, as well as in adults, is likely to have a multifactorial etiology. Radiation, prenatal medications, and genetic factors are all possible etiologic agents in childhood mesothelioma. In addition, other, as of yet unspecified environmental factors may play a role in this disease. When cases are diagnosed, the physician should inquire about the history of exposure to asbestos or other hazardous materials in the patient's environment, prior radiation exposure, medication exposure pre- and postnatally, prior cancer diagnoses, and a family history of cancer. An interdisciplinary approach, combining the diagnostic skills of the pathologist and the analytic skills of the epidemiologist, will be of value and of special relevance in the study of mesotheliomas.
It is widely accepted that transfusions are beneficial to the outcome of renal allotransplantation. Whereas some investigators suggested that transfusions may induce both specific and nonspecific suppression of the cell-mediated immune response, others disagree. To lend clarity to this discrepancy, we collected 40 serum samples before and after blood transfusion therapy of first-time cadaveric renal allograft recipients and evaluated each for T cell and B cell cytotoxic antibodies using an Amos modified complement-dependent microlymphocytotoxicity assay. When greater than 10% of the panel cells reacted with a grade 4 or better, the panel was considered significant, and when a lymphocyte specificity was lysed by antibody-rich serum greater than 50% of the time, the antibody was considered specific. Control T and B cell PRA assays employed sera from 27 normal nontransfused volunteers of similar age and sex. Survival distributions of differences in the PRA before and after blood transfusions and posttransfusion PRA levels were compared using the Gehan generalized Wilcoxon test. Other factors which influence allograft survival such as HLA-A, -B and -DR matches, number of blood transfusions, immunosuppressive therapy, age, sex, parity, previous positive crossmatch, circulating cytotoxic antibodies matching the graft, prior dialysis, length of time on the waiting list, lapse of time between transfusion and transplantation and the underlying primary diagnosis were also considered using the Gehan generalized Wilcoxon test or the chi 2 approximation. Transfusion-related B cell cytotoxic antibodies, HLA-DR monospecific or multispecific antibodies and HLA-A, -B matching extended graft survival in a significant manner. Sex influenced the production of B and T cell transfusion-related cytotoxic antibodies with females producing greater quantities of antibodies than males. Parity and the production of monospecific or multispecific antibody were associated with an increase in transfusion-related B cell cytotoxic antibody. A difference in sex was not linked to the production of monospecific or multispecific HLA-DR antibodies. The majority of males failed to respond to multiple blood transfusions with the production of B cell cytotoxic antibodies although more than half were successfully grafted. All females and males who responded with the production of B cell cytotoxic antibodies monospecific or multispecific, with the exception of 1 female, demonstrated an allograft survival of greater than 1 year. In conclusion, differences between pre- and post-transfusion B cell PRAs and monospecific or multispecific HLA-DR antibodies identified in patient sera following transfusions were good predictors of renal allograft survival in both males and females.(ABSTRACT TRUNCATED AT 400 WORDS)
Research Articles| October 01 2008 An Animal Model of Autoimmune Sialadenitis in Aged Mice Subject Area: Immunology and Allergy , Pathology and Cell Biology Yoshio Hayashi; Yoshio Hayashi Department of Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan Search for other works by this author on: This Site PubMed Google Scholar Chieri Kurashima; Chieri Kurashima Department of Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan Search for other works by this author on: This Site PubMed Google Scholar Masanori Utsuyama; Masanori Utsuyama Department of Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan Search for other works by this author on: This Site PubMed Google Scholar Katsuiku Hirokawa Katsuiku Hirokawa Department of Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan Search for other works by this author on: This Site PubMed Google Scholar Pathology and Immunopathology Research (1989) 8 (2): 118–124. https://doi.org/10.1159/000157143 Article history Published Online: October 01 2008 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Yoshio Hayashi, Chieri Kurashima, Masanori Utsuyama, Katsuiku Hirokawa; An Animal Model of Autoimmune Sialadenitis in Aged Mice. Pathology and Immunopathology Research 1 February 1989; 8 (2): 118–124. https://doi.org/10.1159/000157143 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsSurvey and Synthesis of Pathology Research Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1989Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Enumeration of circulating T lymphocytes is crucial in the investigation of AIDS and related conditions. The single best measure of disease progression and prognosis is the absolute number of helper/inducer T lymphocytes in the peripheral blood. Although the phenotypic identification of a particular subset reflects no direct information on the function of the population, the information provided by the analysis furnishes new insight regarding racial differences in the immune deficiency associated with AIDS. The severity of the HIV illness in the African American population, as reflected by a decrease in the absolute number of circulating CD4+ lymphocytes, was marked compared to the Caucasian population with AIDS. Consequently, the CD4/CD8 ratio was lower in the African American HIV+ population. A higher level of activated mononuclear lymphocytes and NK cells in this population may indicate active disease. The incidence of life-threatening opportunistic infections such as PCP was greater in the adult/adolescent African Americans compared to Caucasians. In contrast, PGL was found more frequently in the Caucasian participants. Although the rate of HIV infection in the adult/adolescent African American population was not different from population estimates for the area under study, the incidence in the pediatric African American population was twice the population estimates for the race. This increased rate occurred in the parent-at-risk as well as in the hemophiliac group.
Research Articles| October 01 2008 Immunohistochemical Localization of Cytochromes P450 with Polyclonal and Monoclonal Antibodies Subject Area: Immunology and Allergy , Pathology and Cell Biology Lucy M. Anderson; Lucy M. Anderson aLaboratory of Comparative Carcinogenesis, Division of Cancer Etiology, National Cancer Institute, FCRF, Frederick, Md.; Search for other works by this author on: This Site PubMed Google Scholar Jerrold M. Ward; Jerrold M. Ward aLaboratory of Comparative Carcinogenesis, Division of Cancer Etiology, National Cancer Institute, FCRF, Frederick, Md.; Search for other works by this author on: This Site PubMed Google Scholar Sang S. Park; Sang S. Park bLaboratory of Molecular Carcinogenesis, Division of Cancer Etiology, National Cancer Institute, Bethesda, Md., USA Search for other works by this author on: This Site PubMed Google Scholar Jerry M. Rice Jerry M. Rice aLaboratory of Comparative Carcinogenesis, Division of Cancer Etiology, National Cancer Institute, FCRF, Frederick, Md.; Search for other works by this author on: This Site PubMed Google Scholar Pathology and Immunopathology Research (1989) 8 (2): 61–94. https://doi.org/10.1159/000157139 Article history Published Online: October 01 2008 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Lucy M. Anderson, Jerrold M. Ward, Sang S. Park, Jerry M. Rice; Immunohistochemical Localization of Cytochromes P450 with Polyclonal and Monoclonal Antibodies. Pathology and Immunopathology Research 1 February 1989; 8 (2): 61–94. https://doi.org/10.1159/000157139 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsSurvey and Synthesis of Pathology Research Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1989Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
