Pemphigus is the name of a group of autoimmune pathological entities characterized by the formation of intraepithelial blisters in the skin and/or mucosa. Pemphigus vulgaris (PV) and Pemphigus foliaceus (PF) are considered as classical forms. Rare, non-classical forms of Pemphigus include: Pemphigus herpetiformis, IgA pemphigus, Paraneoplastic pemphigus, IgG/IgA pemphigus. Aim: Aim of our study is to explore the prognostic influence of clinical, immunological and therapeutic drugs on disease course and remission in different pemphigus variants in Kuwait and to establish a safe and effective multidrug protocol. Plan of the study is to make a correlation between epidemiological factors, therapy used and clinical and immunological remission, as well as, follow up of comorbidities in our patients. 84 patients were evaluated, from 1st January 1990 to 31st December 2013. IVIG is used as a third-line adjuvant treatment initially flanked by high-dose systemic corticosteroids and steroid- sparing immune-suppressants. Thus, this multidrug IVIG regimen made it possible to achieve a rapid control of the pemphigus symptoms, with progression to a stable disease remission, while maintenance an overall safety of treatment.
The mRNA binding protein Tristetraprolin (TTP), encoded by the ZFP36 gene, plays a fundamental regulatory role in a wide variety of cellular processes by means of its widespread expression in different tissues, and of its ability to post transcriptionally regulate the stability, and therefore the expression, of multiple specific target mRNAs. Because of these features, TTP expression and activity are strictly regulated, and malfunctions of such mechanisms underlie different pathologies. Here we recapitulate the role of TTP in the skin, and its involvement in different conditions, with special reference to psoriasis and cancer.
Introduction: Scabies is a neglected tropical public health problem around the world. It is caused by the Sarcoptes Scabiei mite that infested under the skin. The prevalence has been noted as per year is 300 million patients over the world wide. Objectives:To determine the frequency of Scabies at PMCH Nawabshah. Methods: A cross sectional study has been carried out on 422 patients at Peoples Medical Hospital Nawabshah at outpatients Department of Dermatology. The technique of sampling was convenience. A structured questionnaire has been used for data collection and analysis. All data has been collected by researcher on diagnosed cases of scabies by skin specialists. Results: The study is showing prevalence 22.4% among skin problem persons. The mean age of participant 60.2.Sabies can occur at any stage of life The comparison of male and female individuals as 6610 (48%) and 6595 (52%). The marital status of the participants as; married, un-married, widower, divorced and widow was 260 (66.3%) ,118(27.9%),2(0.47%),1(0.23%) and 21(4.97%) respectively and high rate found in lower economic condition Conclusion: The prevalence of scabies at peoples Medical Hospital Nawabshah is 22.4% The prevalence of scabies high in developing countries and this found prominent in back ward areas. The high ratio of scabies is associate with limited resources of basic life. Scabies seems to be neglected tropical problem of health.
Coronavirus disease (COVID-19) is rapidly spread across the world. Many clinical manifestations of the virus are described, and new symptoms are emerging, only few cases of patients with skin manifestation were described since the pandemic was announced by the WHO on March. Common clinical features of COVID-19 reported include fever, cough, myalgia, fatigue, headache, shortness of breath and diarrhea.
Background and Trial Objectives: A new propylene glycol (PG)-free 5% minoxidil (Mnx) (PG-Free-Mnx) lotion has been recently commercialized. Clinical efficacy and local tolerability have been, so far, documented in a limited number of patients. The aim of this study was to evaluate the clinical efficacy, cosmetic acceptability, and local tolerability of 6-month application of this new PG-Free Mnx lotion in a real-life situation. Materials and Methods: The NOMINAL (NO-PG MINoxidil reAL life study) trial was performed in 22 out-patients Italian dermatology clinics. A total of 196 subjects of both sexes with a diagnosis of androgenic alopecia (AGA) and female androgenic alopecia (FAGA) were enrolled in the trial, after their written informed consent. PG-Free-Mnx lotion was applied 1 ml twice daily for 6 months. Clinical efficacy was evaluated in an open fashion in all the enrolled subjects with a 5-grade scale score (from-2: severe worsening, to +2: very good improvement in comparison with baseline condition). In a subgroup of subjects (n=60) an assessor-blinded clinical efficacy evaluation has been also performed using high definition standardized and coded scalp global pictures at baseline, and after 6 months by an assessor unaware of the temporal sequence using a 3-grade score (from 0: no improvement to 3: very high improvement). Cosmetic acceptability evaluation was assessed using a 7-item questionnaire using a 10-point scale score, with score 1 meaning not at all and score 10 meaning the worst possible condition. Cosmetic acceptability and clinical efficacy were evaluated after 12 and 24 weeks of treatment. Global tolerability, assessed at week 24, was evaluated with a 4-grade scale score (from -1: very low tolerability to +2: very good tolerability). Results: All but seven (3.6%) subjects concluded the study. Clinical efficacy scores (open evaluation) were 0.8±0.7 and 1.0±0.7 at week 12 and 24, respectively. Good or very good clinical response (score +1 or +2) at week 12 and week 24 was observed in 64% and 74% respectively of the subjects with a similar response in women (75%) and men (73%). Baseline severity of AGA/FAGA was inversely correlated with the clinical response with a better outcome in subjects with AGA type II in comparison with subjects with types III/IV AGA. The clinical efficacy was confirmed by the assessor-blinded evaluation of the subgroup of 60 subjects’ pictures at baseline (clinical score at baseline: 0.2±0.4 vs. 1.8±0.7 after 6 months; p=0.0001; absolute mean difference: 1.6; 95% CI: 1.1 to 2.0). Cosmetic acceptability score mean values were always <2 at each time-point evaluation, demonstrating good or very good acceptability. Global Tolerability score mean±SD value was 1.7±0.4 with 94% of the subjects reporting good or very good tolerability with no differences between men and women. No subjects reported severe or very severe (Tolerability score >7) burning, itching or redness sensations. Conclusions: This new PG-free lotion shows, in real-life conditions, a very good cosmetic acceptability and tolerability profile. Clinical efficacy, evaluated both in open and assessor-blinded fashions, was also documented, and it was in line with the available data of traditional Mnx formulations with propylene glycol.
Background: Non-surgical minimally invasive procedures, typically in combination, are now becoming the norm. The integrated use of these modalities can be offered to millennial patients, who have unique demands and aesthetic goals. Objective: We aimed to demonstrate the effects of Definisse™ Fillers, Definisse™ Threads and Definisse™ Peel Program in combination to treat two millennials, one female and one male. Case description: The male subject had noticeable change in his facial proportions with correction of hollows over the malar and suborbital areas and a more prominent chin with the help of both Definisse™ Fillers and Definisse™ Threads (double needle and free floating). There was also noticeable improvement in the pigmentation with a more even and clearer skin tone after Definisse™ Lightening Peel application. The patient verbalized a high level of satisfaction with the effects of the treatment overall. The female subject had a noticeable correction of the prominence on her nasal bridge. There was a slightly pronounced lateral and upward lifting of the cheeks. Her uneven pigmentation was also seen to diminish following Definisse™ Peel Program. She was likewise very satisfied and happy with the result of her treatment. Conclusion: The prejuvenation effect of a combination of minimal invasive procedures provides an optimal aesthetic option for millennials. The results obtained confirm the importance of the reharmonize approach to male and female aesthetics. And this is accomplished by working from deep to superficial facial, with satisfactory and long-lasting aesthetic outcomes.
Objective: The present study examined whether dermatological patients’ demographic and social characteristics could predict their satisfaction with the medical outcome. Moreover, it focused on two aspects of patients’ satisfaction; firstly, psychological factors that could predict satisfaction from the medical outcome and secondly, satisfaction from the appearance of their skin, after treatment. Methods: 108 patients (18~35 years) participated in the study. Fifty four were diagnosed by their Dermatologists with severe visible facial cystic acne (Group A) and 54 with non-visible psoriasis/eczema (Group B). The study included two assessment phases: prior to and post dermatological treatment phase. At prior to treatment phase, all patients agreed with their Dermatologist to begin medical treatment and were administered the Sociodemographic questionnaire, the BDD Diagnostic Module-for adults, the Multidimensional body–self relations questionnaire, the Interpersonal support evaluation list and the Rosenberg self-esteem scale. At post dermatological treatment phase (six months after patients completed their dermatological treatment), there was a follow-up assessment and all participants were administered the Questionnaire on patients' satisfaction with the medical outcome. Results: Patients’ previous address to a specialist for their skin disorder predicts lower levels of satisfaction with the medical outcome. Patients' lower overall appearance satisfaction at prior to dermatological treatment phase and the group in which patients belong (visible or non-visible skin disorder), predict higher satisfaction with the medical outcome. The higher the possibility that a patient has a visible skin disorder (group of acne) and the less satisfied they are with their overall appearance at prior to dermatological treatment phase, the higher their satisfaction with the appearance of their skin after treatment is predicted to be. Lastly, if a patient fulfills the criteria for the diagnosis of BDD and the higher their perceived social support at prior to dermatological treatment phase, the lower their satisfaction with the appearance of their skin after treatment is predicted to be. Conclusion: Satisfaction with the medical outcome and satisfaction with the appearance of the skin are two perceptually different areas for dermatological patients. They are both found to be predicted by various psychological factors and as such psychological assessment of patients prior to dermatological treatment is deemed necessary.
Introduction: The use of steroids and the accumulation of fluid within the body have been contributed the worrying presentation of bullous striae distensae which is managed conservatively, and medical interference has not been reported. Case: 13-year-old presented with generalised edema to the ER with abdominal and upper thigh lesions which are diagnosed as bullous striae distensae and it was very tender and erythematous. The patient clinically improved after treating her with antibiotics. Result: Bullous striae distensae can be infected and conservative management is not always the appropriate choice. Conclusion: Consider examining the bullous stria for any perforation or tenderness to prevent and manage suspected infection.
Wound healing is a natural process. The integrity of the skin and injured tissue restoration include many cellular and biochemical phenomena. There are different kinds of conventional dosage forms that are utilised for the wound healing process. Apart from various conventional dosage forms, herbal therapies are gaining more importance nowadays. The herbal therapies are known for their non-habitual nature and have very less side effects as compared to conventional dosage forms. Recently, asiaticoside, an important chemical constituent of gotu kola that is extracted by different methods, is being utilised in wound healing. Asiaticoside has excellent wound healing capability. There are many studies on asiaticoside which reveal that it is a gold herbal compound that is used in the management of wound. Apart from its wound healing activity it also shows antidepressant, antidiabetic, anti-inflammatory, antipyretic action. This review article gives a comprehensive detail of asiaticoside and its various pharmacological actions and pharmacognostic features.
Natural organic compound of group’s complex lipids. They consist of aminoalcohol sphingosine, a fatty acid and carbohydrate (galactose or glucose). Cerebrosides wide presents at tissues man and animals. C their functioning related activity the body at general and on cell level. Cerebrosides contained mainly manner at nervous tissue, especially at myelin shell nerve fibers found also at spleen, lungs, erythrocytes and et al. organs. glucosylceramide or cerebrosides up great part lipids skin where they required for forming lamellar Taurus horny layer epidermis and are mainly barrier permeability water at skin. As a of components biological membranes cerebrosides exert a powerful influence on the functional activity of biological membranes.
