A mild three-component on-DNA reaction enables systematic access to pyrazole-centred DELs while preserving DNA integrity and expanding drug-like chemical space.
A visible light-induced photoredox catalytic synergism has been developed via halogen atom transfer (XAT) and dehydrogenation. The catalytic system, which combined organophotocatalyst and cobalt oxime catalyst, enabled the regioselective construction...
Herein, two 1,2,3-triazole-based conjugated microporous polymers (PTAB and PTAP) with carbazole as electron donor were designed and synthesized via oxidative coupling polymerization. The replacement of benzene core by pyridine endows...
Metal-free light-driven access to non-canonical amino acids: A photoredox-enabled radical–polar crossover strategy unlocks the difunctionalization of dehydroalanine, thereby expanding the toolbox for late-stage amino acid functionalization.
A photo–induced hydrogen atom transfer coupled with a Wittig reaction to access ( Z )–olefins was reported. This transformation exhibits a broad substrate scope, delivering over 30 ( Z )–alkenes in moderate to good yields.
This work reports a mild, oxidant-free visible-light-induced cobalt-catalyzed radical annulation of bicyclic alkenes and secondary phosphine oxides to construct polycyclic phosphorus heterocycles.
This review discusses the photocatalytic cross-coupling of alkyl halides with C-, N-, O-, and S-nucleophiles via SET, conPET, or XAT, compared with traditional S N 1/S N 2 pathways, and is organized by bond-formation type (C(sp 3 )–C/N/O/S).
The development of sustainable synthetic methodologies has become a central objective in modern organic chemistry, driven by the need to minimize environmental impact while maintaining high efficiency and broad applicability....
Selenocyanated isocoumarins 1 could react with PhICl 2 in DMSO to give undocumented selenoisocoumestans 2 (seleno analogues of the naturally occurring isocoumestans) via an exclusive intramolecular decyanative selenocyclization.
We report a visible-light-induced decarboxylative alkylation of dihydrodibenzo[ b , f ][1,4]oxazepines using NHPI esters as alkyl radical precursors using DMC as a green solvent.
Organosilicon compounds are versatile synthetic intermediates, yet silicon substituents are generally treated as static functional groups once installed. Herein, we report an iridium-catalyzed long-range silicon translocation enabled by C-Si bond...
A dual cobalt and photoredox catalysis intramolecular reductive coupling of enynes, enabling the efficient synthesis of vinyl-heterocyclic compounds, has been developed.
A novel aza-BCH-based allylic donor was reported for the first time. A series of methanopyrrolo[1,2- c ]imidazole derivatives were obtained through Pd-catalyzed [3 + 2] cycloadditions, further promoting the development of BCH bioactive heterocycles.
Cobalt-catalyzed defluorinative alkylation of α -trifluoromethyl alkenes with alkyl bromides selectively affords gem -difluoroalkenes or ( E )-monofluoroalkenes by condition control, with broad scope and good tolerance.
Photoexcited nitroarenes serve as HAT catalysts in continuous flow for aliphatic C–H functionalization, enabling Giese additions to electron-deficient alkenes and divergent radical-trapping transformations.
Perplexing effects of an iodine substituent on radical CC bond functionalization were uncovered: despite bond deactivation, novel and efficient cascade functionalizations proceed.
An efficient method for biaryl synthesis via Pd-catalyzed direct dehydroxylative Hiyama-type coupling between phenols and arylsilanes through C–O bond cleavage by using nonafluorobutanesulfonyl fluoride ( n C 4 F 9 SO 2 F) as the activator was developed.
A catalyst dependent (Ag 2 O versus ZnBr 2 ) protocol has been developed for the regiodivergent synthesis of aminobenzofluorenones through either in situ generated or isolated ynones tethered with 2-alkynylanilines in good yields.
We report the first dearomative spirocyclization of BCB-tethered N -benzyl amides with sulfonyl chlorides to afford tricyclic skeletons bearing two sterically hindered spirocycles through a domino sequence.
Dimeric boron complexes bearing isoquinolyl–pyrrole ligands linked through the C3–C3′ positions of the isoquinoline rings were synthesized. Their structural rigidities and substituent effects afforded the unique fluorescence emission properties.
