Benign gallbladder diseases, particularly xanthogranulomatous cholecystitis (XGC), frequently mimic gallbladder carcinoma (GBC) clinically and radiologically, often necessitating radical cholecystectomy to achieve oncological clearance. However, the burden of benign disease undergoing radical resection and the clinicoradiological factors contributing to this diagnostic dilemma remain inadequately characterized. This study evaluated the incidence, spectrum, and predictors of benign pathology among patients undergoing radical cholecystectomy for suspected gallbladder carcinoma. A retrospective observational study was conducted at a tertiary cancer centre including consecutive patients who underwent upfront radical cholecystectomy for suspected gallbladder carcinoma between January 2021 and December 2023. Patients with incidental gallbladder carcinoma following prior simple cholecystectomy were excluded. Clinicodemographic characteristics, serum tumour markers, radiological findings, operative details, and histopathological outcomes were analysed. Univariate logistic regression was performed to identify variables associated with benign pathology. A multivariable logistic regression model incorporating clinically relevant demographic, serological, and radiological variables was constructed to identify independent predictors, and model performance was assessed using receiver operating characteristic (ROC) analysis. Seventy-five patients underwent upfront radical cholecystectomy for suspected gallbladder carcinoma. Final histopathology confirmed malignancy in 54 (72
Partial breast reconstruction (PBR) following wide local excision (WLE) can be performed using local flaps (LF) or latissimus dorsi (LD) flaps; however, real world data evaluating flap choice, perioperative, oncologic, and patient-reported outcomes remain limited. This retrospective single-center study included patients undergoing PBR with LF or LD flap reconstruction after breast-conserving surgery. Clinicopathologic variables, operative parameters, complications, margin status, and patient-reported outcomes using the BREAST-Q were analysed. Multivariable logistic regression was performed to assess factors associated with wound complications. Among 145 patients (LF: n = 92, LD: n = 53), tumors were larger in the LD group (median 3.5 cm [IQR 2.4–4.9] vs. 3.2 cm [IQR 2.3–4.6]; p = 0.026), with more frequent multifocal or multicentric disease (49
To assess whether intraoperative indocyanine green fluorescence angiography (ICG-FA) improves bowel perfusion assessment and reduces clinically detected anastomotic leakage (AL) after laparoscopic colorectal cancer surgery. In this single-center, parallel-group pilot randomized controlled trial, 44 adults with operable colorectal carcinoma scheduled for elective laparoscopic colorectal resection were allocated 1:1 to fluorescence angiography or conventional perfusion assessment. The primary outcome was AL within 30 postoperative days. Secondary outcomes included operative time, change in transection line, postoperative complications, length of hospital stay, reoperation, readmission, and conversion to open surgery. Forty-three patients were included in the final analysis: 22 in the ICG-FA group and 21 in the non-ICG group. Operative time was shorter in the ICG group than in the non-ICG group (205.95 +/- 27.23 vs. 221.52 +/- 27.60 min; p = 0.070), although this finding should be interpreted cautiously. Conversion to open surgery occurred in one patient in each group. Anastomotic revision was performed in one patient in the ICG group. The transection point was changed in five patients in the ICG group and two patients in the non-ICG group. AL occurred in 2/21 patients (9.52
