A group of male rabbits were tested in 9 separate groups: the 1st acted as a control the 2nd was injected with a 2% solution of synestrol the 3rd was injected with estradurin the 4th with estracyte and the 5th with hovan. The remaining 4 groups in addition to receiving the above 4 hormones were injected with nonpathogenic strains of B. coli (0-111 and 0127). Those animals that were administered synestrol and estracyte and the B. coli contracted pyeolonephritis. The other hormonally treated animals receiving B. coli showed considerable destructive changes although no signs of inflammation. Investigations of 86 human patients with cancer of the prostate gland showed that after estrogen therapy 61 of them had signs of pyelonephritis and 44 had dilation of the upper urinary tract. These results led to the conclusion that hormonal therapy was the cause of these side effects. (Authors modified)
