Objective:To analyze the expression and clinical significance of ATP-citrate lyase(ACLY)and Lysophosphatidylcholine Acyltransferase 1(LPCAT1)in Oral Squamous Cell Carcinoma(OSCC).Methods:TCGA database was used to analyze the expression of ACLY and LPCAT1 in oral squamous cell carcinoma.Immunohistochemistry was used to detect the expression of ACLY and LPCAT1 in OSCC and paracancerous normal tissues,explore the relationship between their expression and clinical pathological features and prognosis of patients.Results:TCGA database showed that high expression of ACLY and LPCAT1 in OSCC(P＜0.05);The results of immunohistochemistry showed that high expression of ACLY and LPCAT1 in OSCC(P＜0.001).The expression of ACLY was correlated with the differentiation degree of OSCC(P=0.009).The expression of LPCAT1 was correlated with the differentiation degree of OSCC(P＜0.00 1).Spearman analysis showed that the expression of ACLY and LPCAT1 in OSCC was positively correlated(r=0.449,P＜0.001).Kaplan-Meier survival analysis showed that patients with high ACLY and LPCAT1 ze-xpression had shorter survival time(P＜0.05).Cox multivariate analysis showed that LPCAT1 expression level(P＜0.05)was an independent prognostic factor of OSCC.Conclusion:High expression of ACLY and LPCAT1 in OSCC and there is a positive correlation between them.LPCAT1 is expected to be a metabolic biomarker for independent prognosis of OSCC.
Objective:To understand the current situation of dementia fear in community elderly in Shihezi City and analyze its influencing factors.Methods:From December 2021 to May 2022,convenience sampling was used to select 452 elderly people from 2 communities in Shihezi City as the research objects.The general information questionnaire,dementia Fear Scale,Self-perceived Aging Scale and Family Care Index questionnaire were used to investigate them.Results:The total score of dementia fear was(52.84±13.83),the total score of self-perceived aging was(54.69±12.58),and the total score of family care index was 5.00(3.00,9.00).Dementia fear was positively correlated with the total score of self-perceived aging and its dimensions(P＜0.05),and negatively correlated with the total score of family function and its dimensions(P＜0.01).Multiple linear regression analysis showed that age,whether to take care of dementia patients,the total score of self-perceived aging,and the total score of family care were entered into the regression equation(P＜0.05),which explained 50.7％of the total variation of dementia fear in community elderly people.Conclusion:shihezi city community elderly dementia fear of moderate level,age,ever care for dementia patients,self-perception aging,family function is the main influencing factors of dementia fear,fear,community health workers should pay attention to the dementia targeted intervention measures,help the elderly to adjust negative emotions,positive transfer the function of family,In order to reduce their dementia fear level.
Objective:To investigate the diagnostic value of inflammation and coagulation indexes in ovarian endometriosis(EMs).Methods:The clinical data of patients with ovarian EMs and control group were analyzed retrospectively,and the differences of inflammatory indexes,coagulation indexes and tumor markers were compared,and the combined diagnostic indexes were analyzed by Logistic regression.Results:Lymphocyte count(L),neutrophil count/lymphocyte count(NLR),platelet count/lymphocyte count(PLR),systemic immune inflammatory index(SII),platelet count(PLT),fibrinogen(FIB),D-dimer(D-D),carbohydrate antigen 125(CA125)and carbohydrate antibody in EMs group The expressions of proto199(CA199)and human epididymal protein 4(HE4)were different from those of non-EMS group,and CA125,PLR and FIB were significantly correlated with the occurrence of ovarian EMs(P＜0.05).The diagnostic efficacy of CA125 combined with PLR,CA125 combined with FIB and the three combined methods were improved.Conclusions:Inflammatory factors(L,NLR,PLR,SII)and coagulation factors(PLT、FIB,D-D)are diferentially expressed in ovarian EMs,and the combination of CA125,PLR and FIB can help distinguish ovarian EMs from other benign ovarian tumors,which has certain diagnostic value.
目的:本文旨在分析高质量发展背景下患者就医体验的现状,并提出相关对策.方法:采用横断面研究法调查医院患者就医体验现状,并通过多元线性回归分析,探讨性别、年龄、文化程度、婚姻状况、家庭人均月收入等对患者就医体验的影响.结果:医院患者就医体验处于中等水平,患者性别、年龄、文化程度、家庭人均月收入、医疗费用支付方式和医院级别与患者就医体验存在显著关联.结论:本研究提出了一系列改善患者就医体验的对策,包括提升医务人员的沟通和人文关怀能力、加强医疗服务的个性化和综合性、改善医疗设施和环境、强化医院管理和服务流程及加强患者教育和信息共享;通过实施相关对策,可提高医院患者的就医体验,增强医疗服务的质量和患者满意度.
Objective:To investigate the influencing factors of incision infection in gastrointestinal surgery,and to put forward preventive suggestions and measures.Methods:The patients who underwent gastrointestinal surgery from January 2017 to December 2021 were selected as the research objects,screened according to the inclusion and exclusion criteria,6 227 cases were included,and they were divided into infection group and non-infection group according to the outcome of surgical incision infection.45 patients were selected.The patients with surgical incision infection were selected as the infection group,and 6 182 gastrointestinal surgery patients without incision infection were selected as the non-infection group.The differences in general conditions and related indicators of the two groups of surgical patients were compared,and the relevant risk factors were statistically analyzed by binary logistic regression.Results:Among 6 227 patients undergoing gastrointestinal surgery,45 had postoperative infections,with an infection rate of 0.7％.There was a statistically significant difference(P＜0.05);There was no statistically significant difference between the two groups in terms of age,incision type,preoperative use of antibiotics,use and postoperative use of antibiotics(P＞0.05).The binary logistic stepwise regression analysis showed that the influencing factors of gastrointestinal surgical incision infection include gender,length of hospital stay,surgical timing,consecutive surgeries,and surgical duration.The main pathogenic bacteria for level 0 incision infection are Gram positive bacteria,while for level Ⅲ surgical incision infection,Gram negative bacteria are the main pathogenic bacteria.Conclusion:Gastrointesti-nal surgical incision infection is influenced by gender,length of hospital stay,surgical timing,consecutive surgeries,and surgical duration.In clinical practice,it is necessary to strengthen the management of consecutive surgeries,strictly aseptic procedures,pay attention to early identification of patient susceptibility to infection,timely shorten surgical time,reduce tissue damage,and effectively control the risk of infection;If a surgical incision infection occurs,the use of em-pirical antibiotics can be based on the type of incision before secretion culture and drug sensitivity results are available.
This paper mainly expounds the design idea and implementation process of the ideological and political case teaching of"Communication Skills for the Aged"course based on PBL teaching method.This course is the core course of a major,which focuses on cultivating students'communication ability in the elderly service work,improving students'comprehensive quality and professional level.Ideological and political education is of great responsibility.The teaching is implemented step by step by the linkage mechanism,and the teaching effect is analyzed and demonstrated,ideological and political education into the mind,to achieve the unity of knowledge,ability and quality goals.
目的:讨论克氏针锚定技术辅助椎间孔镜下可视化关节突成型的可行性及临床疗效.方法:回顾2019年1月-2021年1月行椎间孔镜手术并获得完整随访的60例腰椎间盘突出症(LDH)患者的临床资料.对照组(30例)使用常规椎间孔镜下可视化成型技术,实验组(30例)使用克氏针锚定技术辅助下可视化成型技术;比较两组不同成型方法下手术时长、术中透视次数、成型时及术后第1天VAS评分、术后第1天ODI评分.结果:所有患者均在局麻下顺利完成椎间孔镜下关节突成型、髓核摘除术,实验组平均手术时长(41.22±2.21)min;术中平均透视(2.11±0.56)次,成型时VAS评分为(4.10±0.21)分,术后第1天VAS评分为(2.33±0.14)分,术后第1天ODI评分为(20.20±1.15);对照组:平均手术时长(55.22±6.21)min;术中平均透视(5.13±0.37)次,成型时VAS评分为(4.52± 0.26)分,术后第1天VAS评分为(2.27±0.41)分,术后第1天ODI评分为(20.71±1.50).两组均无神经损伤、硬膜撕裂和切口感染等早期并发症发生.两组比较手术平均时长及透视次数差异具有统计学意义(P＜0.05),成型时及术后VAS评分、术后ODI评分两组比较差异无统计学意义(P＞0.05).结论:克氏针锚定技术辅助椎间孔镜下可视化成型技术疗效确切,安全性高,可有效降低椎间孔镜下关节突成型的学习曲线,缩短手术时间,减少透视次数,值得推广应用.
目的:观察超广角激光眼底照相在视网膜钝挫伤患者检查中的应用.方法:回顾性2019年8月-2022年8月在我院治疗的38例(38眼)视网膜挫伤患者为研究对象,采用超广角激光眼底照相对患者进行检查,观察患者超广角眼底照相特点和自发荧光影像特点.结果:超广角激光眼底照相和自发荧光影像在视网膜钝挫伤患者的临床检测中均可呈现特征性改变,且同一患眼可伴有脉络膜破裂、视网膜裂孔、视网膜出血以及视网膜震荡及损伤等情况发生.结论:超广角激光眼底照相及自发荧光影像在视网膜钝挫伤患者中具有较好的应用效果,有助于监测视网膜病变患者视网膜损害程度及预后评估.
目的:调查孕妇对本地区产前筛查相关知识的认知及围产保健知识的了解情况,了解其与社会人口特征、产科病史及相关社会因素各变量的关系.方法:选取新疆石河子参与产前筛查的妇女715名参与调研.自行制定调查量表,该表包括孕妇的个人基本情况和产前筛查知识相关的问题两个部分.采用统计学方法分析影响孕妇产前筛查相关知识认知的相关因素.结果:经产妇与初产妇在对产前筛查及围产保健知识的认知度上无明显差异性(Z=-0.284;P=0.777).产前筛查及围产保健知识了解程度与孕妇学历(Z=-4.306;P=0.000)、有无职工医保(Z=-2.189;P=0.029)、孕妇有无收入(Z=-2.172;P=0.030)相关性较强.结论:石河子地区孕妇产前筛查知识认知需要提高,文化程度、个人经济收入、职工医保是其影响因素;建议增加线上、线下知识宣传渠道,提高医疗人员遗传咨询能力,以进一步提高本地区孕妇产前筛查的依从性.
Objective:To explore the disease cognition and health education expectation of patients with sleep apnea syndrome,and to provide reference for clinical intervention and health education model.Methods:A semi-structured interview was conducted with 20 patients with sleep apnea syndrome using the phenomenological research method,and the interview data were collated,analyzed and summarized with the Colaizzi seven-step analysis method.Results:Through analysis and summary,three themes were extracted:disease cognition,health needs,and health education model.Conclusion:Nurses should pay more attention to health education for patients with sleep apnea syndrome,provide patients with networked,personalized and continuous health guidance,help patients with disease self-control and management,and gradually improve the quality of health education.
Objective:To compare the effect of NICE junction suture with Krackow suture and vertical wire suture with Krackow suture in the treatment of lower pole fracture of patella.Methods:35 patients with lower pole fracture of patella were retrospectively analyzed.According to different internal fixation methods,19 patients in group A were treated with vertical high-strength line NICE suture combined with Krackow suture.16 patients in group B received vertical wire fixation combined with Krackow suture.Result:All patients showed bone union on imaging.Thirty-five patients were followed up with an average follow-up time of 10.09±3.05 months.There was no significant difference in Bostman score between the two groups at 2 weeks,1 month and 3 months after surgery(P＞0.05).Bostman score in group A was better than that in group B(P=0.027).Conclusion:Both vertical high-strength suture with NICE suture combined with Krackow suture and vertical wire fixation combined with Krackow suture can achieve good clinical efficacy in the treatment of lower pole fracture of patella.Vertical high-strength suture with NICE suture combined with Krackow suture has the advantages of not taking out internal fixation and avoiding the irritation of metal plants on the skin.It is an optional treatment for fracture of the lower pole of patella.
Objective:To explore the application of transurethral plasma enucleation of prostate(TTUPEP)in the treatment of benign prostatic hyperplasia in grassroots hospitals.Methods:80 patients with benign prostatic hyperplasia admitted to our hospital from January 2020 to January 2023 were selected,including 40 cases each of traditional prostate electrodesis and plasma enucleation,the operative time,intraoperative bleeding,indwelling catheterization,post-operative hospitalization time and improvement of postoperative lower urinary tract symptomswere observed in both groups.Results:10 enucleated patients were transferred to electrodesiccation,and the operative time of the enucleated group was not significantly different from that of the electrodesiccated group,but the intraoperative bleeding,indwelling catheterization time,postoperative hospital stay and improvement of postoperative lower urinary tract symptoms were significantly better than those of the electrodesiccated group,and the difference was statistically significant(P＜0.05).Conclusion:Prostate plasma enucleation has the advantages of complete removal of glandular tissue,few postoperative complications and high safety,and it is worth promoting prostate plasma enucleation in grassroots hospital.
目的:了解大学生对急救知识的掌握情况与需求,探索急救教育的途径,为高校构建高质量急救教育体系提供参考.方法:采用随机抽样调查方法于2022年10月-12月向石河子大学在校本科生发放调查问卷3 810份,收回问卷3 810份,其中有效问卷3 713份.采用Excel 2019统计并整理数据,运用SPSS 26.0软件对数据进行统计学分析.结果:(1)急救知识方面:在校本科生的急救知识总体得分最高分为15分,最低1分,平均得分为(10.29± 2.60)分.(2)急救意识与态度方面:92.86％的大学生完全支持急救教育;67.33％的大学生愿为他人施救;86.21％的大学生担心自己缺乏经验而对患者造成二次伤害;在本科生最感兴趣的急救项目调查中显示创伤急救(78.00％)和心跳呼吸骤停抢救(74.41％)占比最高.结论:在校本科生急救知识储备不够、技能掌握不足,缺乏施救信心且顾虑较多,但急救培训需求强烈.高校应加强在校本科生急救知识的培训并完善保障制度,加大大学生急救培训的推广力度,加速急救教育体系的构建.
Objective:To analyze associations of IL-6 and CCL2 with prostate cancer and its bone metastasis,and evaluate diagnostic values.Methods:Serum IL-6 and CCL2 levels were detected and compared between prostate cancer patients(with and without bone metastasis),prostatic hyperplasia patients and health controls.Receiver operating characteristic(ROC)curves were used to evaluate diagnostic values of IL-6 and CCL2 in individually and jointly diagnosing prostate cancer and its bone metastasis.Results:Serum IL-6 and CCL2 levels were higher in prostate cancer patients than in prostatic hyperplasia patients and health controls,and higher in prostatic hyperplasia patients than in health controls,and higher in prostate cancer patients with bone metastasis than in prostate cancer patients without bone metastasis.The AUCs of IL-6 combined with CCL2 in diagnosing prostate cancer and its bone metastasis were significantly higher than those of individual diagnosis(prostate cancer:0.911 vs 0.718,0.691,both P＜0.001;bone metastasis:0.909 vs 0.714,0.693,P=0.048,0.046).The sensitivity and specificity of joint diagnosis for prostate cancer were 81.8％and 90.3％,respectively.The sensitivity and specificity of joint diagnosis for bone metastasis were 88.9％and 87.0％,respectively.Conclusion:The combined detection of IL-6 and CCL2 may be used in the diagnosis of prostate cancer and its bone metastasis.
Objective:The regional differences and spatial-temporal distribution patterns of medical fund input of National Natural Science Foundation of China(NSFC)were analyzed to provide reference for optimizing the regional distribution of science fund and promote balanced and coordinated development of regional innovation in medical sciences.Methods:Based on the data of medical projects funded by the NSFC,this paper comprehensively uses the multivariate analysis methods such as coefficient of variation,locational Gini coefficient,spatial autocorrelation natural discontinuity classification,and spatial concentration to explore the geographical distribution differences,spatial patterns and their changes of scientific research funding in medical field.Results:The number and amount of funding for NSFC medical projects have increased significantly,from 607 projects and 128 million yuan in 2000 to 10 192 and 4.647 billion yuan in 2019.At the regional level,the medical funding of the NSFC was concentrated in East and North China,with the cumulative proportion increasing from 54.56％during 2000-2004 to 58.19％during 2015-2019.The analysis of the coefficient of variation and the Gini coefficient of location showed that although the provincial difference of the NSFC medical fund investment has been improved,there is still a large gap.The classifi-cation map shows that the medical funding of the NSFC is mainly concentrated in Beijing,Shanghai,Guangdong,Jiang-su.From the perspective of temporal and spatial evolution trend,the"center of gravity"of investment shifted from Beijing to Shanghai,and the high-level regions gradually converged to the eastern coastal provinces.Conclusion:The medical funding of NSFC showed a large increase trend,and the difference between provinces was gradually reduced,but the spatial differentiation pattern was obvious in provinces,and the difference between regions was large and showed an expanding trend with the passage of time.Therefore,relevant departments should formulate measures to op-timize the allocation of medical science and technology innovation resources and promote the coordinated development of medical science innovation in various regions.
Objective:To collect and analyze the laboratory results of patients with bone pain caused by three etiologies,improve the diagnostic efficiency of multiple myeloma diseases with primary symptoms like bone destruction or lumbar compression fracture.Methods:All cases of bone pain were reviewed from August 2016 to June 2022.All patients were divided into 4 groups:Group multiple myeloma(n=16);Group bone destruction(n=16);Group lumbar compression fractures(n=17);Group healthy persons(n=17).After admission,all four groups of patients were recruited from fasting venous blood to measure indexes.Observation index:One-way ANOVA,rank sum test or x2 test were used to analyze the differences between the four groups.Results:The biochemical examination(total protein,globulin,cystatin C)in the multiple myeloma group was higher than other groups(P＜0.05),the difference was statistically significant;The biochemical tests(albumin,white ball ratio)and blood routine tests(hemoglobin,red blood cell count,hematocrit)in the multiple myeloma group were lower than those in the bone destruction group and the lumbar compression fracture group,with a P＜0.05,and the difference was statistically significant.Conclusion:For patients whose primary symptoms is bone pain but the above laboratory test indicators are abnormal,the possibility of multiple myeloma should be considered,so as to reduce the possibility of misdiagnosis.
The student-centered ideological and political course of medical microbiology is based on students participating in the whole teaching process,and through the teaching method of"acting,doing,identifying,learning,and evaluating",to give full play to the"virtual,personalized,unique and It enables students to cultivate"scientist spirit,core values,critical thinking,and innovative thinking"while learning the knowledge of pathogenic microorganisms,so as to achieve the silent educating effect of classroom teaching.
目的:在全科住院医师规范化培训中,对比问题驱动教学(Problem-Based Learning,PBL)联合临床路径(Clinical Pathway,CP)法与传统临床带教方法的差异.方法:对石河子大学第一附属医院2020级(20名)及2021级(21名)全科住培学员分别采用传统带教方法和PBL联合CP法以"胸痛"病例进行临床带教.通过理论考核、技能考核和主观评价问卷对PBL联合CP法和传统带教方法进行比较.结果:2021级的理论考核成绩和技能考核成绩均高于2020级(P＜0.05);且在激发学员的学习兴趣、培养良好临床思维、规范临床处置和带教满意度方面PBL联合CP法优于传统带教法,两组比较差异具有统计学意义(P＜0.05).结论:在全科专业住院医师规范化培训中,PBL联合CP法可以作为传统带教的有益补充,具有较好的教学效果.
针对目前西医院校中医学课程思政建设的现状,笔者从课程思政的内涵、课程评价体系、课程思政元素融入、德育方法等方面进行探讨,深入挖掘中医文化立德育人的内涵,提高中医学教师队伍的德育素养,优化改进课程评价体系和教学方法,充分调动学生学习中医的热情和积极性,使学生领悟到中华传统文化的博大精深,增强中医药文化自信,推动课程思政落地生根.
目的:探讨兵团医学领域科研合作网络现状及演化趋势.方法:采用社会网络分析法,以1996-2021年石河子大学医学院在CNKI数据库中发文数据为研究对象,对发文量、网络密度、关联度、中心性、小世界特性等指标展开分析.结果:发文量整体上呈上升趋势,节点数与关系条数在2016年以前增长较快,网络密度、平均最短路径和关联度均呈上升趋势;近三年科研合作率为54.92％.中心性分析显示,石河子大学医学院、石河子大学第一附属医院等机构在科研合作网络中占据中心位置,预防医学、病理学等学科科研合作频率较高;科研合作网络满足小世界特性.结论:兵团医学领域科研合作网络规模和质量不断提升.
