Deep Vein Thrombosis (DVT) is caused by a blood clot that occurs in the deep venous system. DVTs are rare in they healthy children, but may occur more commonly in children that are hospitalized or have chronic diseases. Children with cystic fibrosis have a higher risk to develop deep vein thrombosis. Signs and symptoms of DVT include swelling, pain, and changes in skin color of the affected limb. Diagnosis of DVT is usually confirmed with an imaging test such as an ultrasound. Treatment for DVT includes waiting and watching to see what happens, medication, thrombolysis, or surgery. We describe a child with cystic fibrosis who presented a deep vein thrombosis of left leg as a cause of dehydration and vitamin E deficiency
1 Pediatr Ther, Vol.11 Iss.4 The exact prevalence of this illness is unknown, and almost all the information available come from developed countries. The PALF study group, created in order to deepen the knowledge on this disease, enrolled 348 patients over 5 years, coming from 24 centres located in Europe and North America. Data from developing countries are scarce, with the few studies available realized in India and South Africa [3-5]. Aetiology in PALF varies significantly according to age and worldwide location. Identifiable causes include infections, metabolic diseases, Drug-Induced Liver Injury (DILI), immunemediated damage, malignancies, and vascular/ischemic injury Pediatric Acute Liver Failure in Central African Republic: Epidemiology and Prognostic Modeling Silvia Radaelli1,2, Ghislain F. Houndjahoue1,2*, Olivier B. Bogning Mejiozem1, Vittoria Mattei1,2, Donata Galloni1,2, Cecilia Martin3, Jean-Chrysostome Gody1,4 Centre Hospitalier Universitaire Pédiatrique de Bangui (CHUPB), Avenue de l'Indépendance, Bangui, Central African Republic;Médecins avec l'Afrique CUAMM International NGO, via San Francesco 126, 35121 Padova, Italy;King Abdullah University of Science and Technology (KAUST), 23955 Thuwal, Saudi Arabia;Faculté des Sciences de la Santé (FACSS), Université de Bangui, Avenue des Martyrs, Bangui, Central African Republic
A practicing physician in the field of healthcare in the state of Kerala in India for the last 31years and very much interested in basic research. My interest is spread across the fever, inflammation and back pain. I am a writer. I already printed and published nine books on these subjects. I wrote hundreds of articles in various magazines. I also prepared 8000 Affirmative cross checking questions. It can explain all queries related to fever After scientific studies for a long time, I have developed a theory, which can explain all queries related to fever. The real science of fever can be termed as the Physics of fever. I have written 3 books about fever in Malayalam language.
Managing acute appendicitis during current COVID-19 pandemic is proving to be quite challenging. The gold standard treatment for acute appendicitis is appendectomy; however, exceptional situation related to COVID-19 has led us to reconsider medical treatment alone as an alternative in selected patients. We present a case of 10 years old boy, who was diagnosed with COVID-19 and acute appendicitis. This report illustrates the possible challenges of determining if COVID-19 is the cause of acute appendicitis or it is merely a co-incidence that a case of acute appendicitis got tested positive for COVID-19.
The balance between Th17/Treg in peripheral blood and reproductive tissues can play a role in unexplained recurrent pregnancy loss (URPL) pathogenesis. The aim of the present study was to evaluate the signature cytokine and Tregulatory marker (TGF-β and FOXP3) as well as the evaluation of the determinant cytokine of Th17 cells (IL-17A) in patients with URPL and healthy women. Samples from 14 patients with URPL were taken as a case group and 12 normal no pregnant women as a control (normal) group collected from peripheral blood, endocervix, endometer and vagina. Gene expressions were measured by qRT-PCR. The serum and cervicovaginal fluid levels of cytokines were measured by ELISA. IL-17 gene expression was significantly higher in peripheral blood in women with URPL compared to control group (P=0.01). The cervicovaginal fluid TGF-β level in the case group and the normal group was different (P=0.015). This study indicated that dysregulation of systemic immune responses may reduce regulatory immune responses in reproductive tissues which may play a critical role in the pathogenesis of URPL.
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Background Preterm related complication is a critical neonatal problem in the world causes death of nearly one million neonates per each year. In Ethiopia, it is still the first leading causes of neonatal mortality accounts 37% from the total neonatal death. Identifying factors associated with preterm mortality by conducting a research is one of the mechanisms used to tackle such kinds of critical public health problems. Hence, this study aimed to assess the mortality and its associated factors among preterm neonates admitted to neonatal intensive care units of Addis Ababa public hospitals, 2021. Methods and Materials An institutional based prospective follow up study was conducted among 358 preterm neonates admitted to selected public hospitals of Addis Ababa, Ethiopia from February 12 to May 12, 2021. Systematic random sampling was used to recruit each sample and data was collected prospectively using structured questioner. Bivariable and multivariable logistic regression were computed. Variables having P-value <0.05 in bivariable logistic regression were taken to multivariable logistic regression model to adjust for possible confounders. Variables with P-value <0.05 (CI:95%) in multivariable logistic regression were declared as significant factors. Result At the end of the cohort the proportion of preterm mortality was (34.9%). Thrombocytopenia (AHR: 0.26, CI; 0.68,0.95), dehydration (AHR:6.00, CI:2.1,20.0), hospital acquired infection (AHR: 5.6, CI:1.6,20.8) and CPAP type (AHR: 4.0, CI:1.5,10.5) were statistically significant factors having P- value<0.05. Conclusion In this study, the proportion of preterm mortality was high. Thrombocytopenia, dehydration, hospital acquired infection and being kept on homemade CPAP type were the associated factors for preterm death.
