目的探讨特急性外伤性颞叶疝的外科治疗方法。方法2004年6月~2006年5月采用标准外伤大骨瓣开颅,钩回、海马回复位术治疗特急性外伤性颞叶疝49例,与2002年6月~2004年5月采用常规骨瓣减压、血肿清除术救治的55例同类患者进行疗效比较。结果按哥拉斯哥预后评分（Glasgowoutcome scale,GOS）进行疗效评价,标准外伤大骨瓣开颅,钩回、海马回复位组恢复良好18例占36.73%,中度残疾9例占18.37%,重度残疾6例占12.24%,持续性植物生存4例占8.16%,死亡12例占24.49%;常规骨瓣减压、血肿清除组恢复良好10例占18.18%,中度残疾5例占9.09%,重度残疾12例占21.82%,持续性植物生存5例占9.09%,死亡23例占41.82%。两组比较具有显著性差异（P＜0.05）。结论标准外伤大骨瓣开颅,钩回、海马回复位术是治疗特急性外伤性颞叶疝的有效方法。
Objective To explore health-related quality of life and analyze associated factors in migraine patients.Methods SF-36 Chinese Edition was used to carry out the survey face-to-face in 122 migraine patients and 112 healthy controls.The scores of quality of life in the two groups were compared withTwo-Sample T-Test,and the influencing factors for the quality of life were screened in the migraine group with multiple stepwise regression analysis.Results Migraine group scored significantly lower than control group in all the 8 domains including physical functioning,role-physical,bodily pain,general health,vitality,social functioning,role-emotional,and mental health.Factors associated with physical summary score were headache frequency,headache severity and education in migraine group;Factors associated with mental summary score were headache severity,headache frequency,duration of disease and education in migraine group.Conclusions Migraineurs had a reduced quality of life relative to healthy controls,quality of life for migraine suffers may be improved by intervening the associated factors,especially headache frequency and headache severity.
Objective To examine the psychological characteristics of personality(PCP) of alcohol addicts voluntarily seeking temperance and their influence on relapse after temperance.Methods A comparative analysis of PCP was made between alcohol addicts voluntarily seeking temperance(n=30) and healthy persons(n=30) via MMPI,based on these data the connection between PCP and relapse was found.Results There is significantly difference between the addicts and healthy persons in almost every deal of MMPI,such as F,PP,HS,PA,SC and so on.The difference is considered to basing the direct connection with relapse.Conclusions PCP of alcohol addicts is their antisocial manner and obstruction of adaptation to normal social life,over attention to their health and lacking of attributive to the society.They make their manners rationalization and attribute the bad manners to other people.PCP increases the rate of relapse.
Objective To observe the therapeutic effects of Vital Stim electrical stimulation on deglutition disorders in stroke patients.Methods Seventy-five patients with deglutition disorders after stroke were randomly divided into Vital Stim electrical stimulation group (received Vital Stim electrical stimulation besides deglutition training, routine therapy of drug and acupuncture), acupuncture group (received acupuncture besides deglutition training and routine therapy of drug), deglutition training group (received deglutition training and routine therapy of drug). The therapeutic effects were assessed with the degree of deglutition function before treatment, one week after treatment and two weeks after treatment.Results After treatment, scores of three groups were significantly higher than those before treatment(P0.01), and those in Vital Stim electrical stimulation group were higher than other groups(P0.01); The effective rate of Vital Stim electrical stimulation group was higher than those of other two groups(P0.05).Conclusions Vital Stim electrical stimulation could significantly improve the curative effect of the patients with deglutition disorders after stroke, more effect will get if added with deglutition training and acupuncture.
物质依赖(滥用)个体的原生家庭特点和成长于物质依赖(滥用)家庭的个体所表现出的特点两方面,对家庭因素与物质滥用个体之间存在的相互关系进行综述.揭示了与个体物质依赖(滥用)行为有明显相关的家庭因素,包括:较差的教养行为、低社会经济地位、不良教育环境、"专制式"的家庭氛围、家庭结构松散,缺乏凝聚力、父母存在物质滥用问题等;而成长于物质滥用家庭中的儿童则会表现为:受到更多虐待、执行功能能力下降、高攻击性、反社会人格等.在对从20世纪80年代开始的在物质依赖(滥用)个体的家庭特点的相关性研究基础上,进而探讨了物质依赖(滥用)家庭的代际传承的模型.
Objective To study the effects of network behavior and psychological intervention in the youth network addicts.Methods Internet Addiction questionnaire,the use of network behavior questionnaire as research tools,tested the network addicts in the high school students,as well as did the psychological intervention on these internet addicts.Results Playing online games is one of the Internet Addiction risk factors,the motivations include:boredom,wasting time,making new friends.Psychological intervention have some effects on improving the addict network-dependent.Conclusions Concern the Internet Addiction young people,closely focus on youth mental health education,and strengthen psychological intervention on the Internet Addicts.
Objective To investigate the effects of exogenous insulin-like growth factor binding protein-2 (IGFBP-2) on activation of focal adhesion kinase (FAK) signaling pathway in U251 human glioblastoma cells.Methods Western blotting analysis and immunofluorescence staining were used to examine the effects of IGFBP-2 on phosphorylation of FAK in U251 cells.Results Compared with the control, phosphorylated FAK in U251 cells increased by nearly one-fold after treated with 500 ng/ml IGFBP-2 for 5min (P0.05), while in U251 cells treated with 500ng/ml IGFBP-2 for 30min, phosphorylated FAK increased by nearly two-fold (P0.01).Conclusions IGFBP-2 may enhance migration and invasion of glioma cells through FAK pathway.
Objective To investigate the expression of Caspase-3,Bcl-2 and Bax in rats after cerebral ischemia-reperfusion.Methods 36 male Sprague-Dawley rats were randomly divided into 2 groups: sham operation group(sham) and cerebral ischemia group(CI).The focal cerebral ischemia models of rats were established by the left middle cerebral artery occlusion(MCAO) with Longa's methods.Reperfusion began 2h after the left middle cerebral artery occlusion.At the prescriptive time,the rats were killed and decapitated to gain brains.Immunohistochemistry method was used to detect the expression of Caspase-3,Bcl-2 and Bax.Results Compared with the sham operation group,the expression of Bcl-2,Bax and Caspase-3 increased obviously in cerebral ischemia group(P0.01).Conclusions The ascended expression of Caspase-3 and Bax promoted the cell apoptosis but the ascended expression of Bcl-2 restrained the cell apoptosis after the transient cerebral ischemia-reperfusion.
Objective To study the effects on post stroke depression patients treated with paroxetine.Methods In this study,a total of 272 patients with acute brain stroke were assessed with SDS,SAS.Of these 272 patients 81 who meet the criteria of depression and anxiety after acute brain stroke of ICD-10 were recruited.These 81 patients were treated with routine antistroke medication(Control group),routine antistroke medication with Paroxetine(Group Ⅰ)and routine antistroke medication with Paroxetine joint psychotherapy(Group Ⅱ)respectively for 6 weeks.The rating scales such as SSS,HAMD,HAMA,and BI and so on were used to evaluate the symptoms improvement and side effects.Results The rate of poststroke depressive combined with anxiety in acute stroke was 29.78%,the comorbidity was 65.85%.According to the decline of SSS score,HAMD score,HAMA score,and increase of BI score of the patients,significant improvement has been showed in all patients.There were significant difference between trial groupⅠ or trial groupⅡ and the controlled group(P0 01).Conclusions All of the three projects had effects on the patients with Poststroke depression with anxiety,routine antistroke medication with Paroxetine is better.
Objective To investigate the relationship between circulating antigen in sera and neuroimaging in neurocysticercosis.Methods According to the four standards diagnosing neurocysticercosis introduced by Brutto in 2001,36 patients of neurocysticercosis were given quantitative assay of circulating antigen in sera and neuroimaging test.Results According to the neuroimaging test of all 36 cases,quantitative assay showed the circulating antigens in active stage,early degeneration of stage,later degeneration of stage and calcic stage have significance difference(P0.01).The quantitative of circulating antigen in sera has positive correlation with stage of neuroimaging and the correlation coefficient is 0.871.Conclusions(1) The circulating antigen in sera has the correlation to neuroimaging in neurocysticercosis.(2) Testing of circulating antigen in sera of patients can be used for early diagnosis as well as for direct clinical treatment.
目的在住院缺血性卒中患者的TOAST病因分型基础上,研究各亚型与近期炎症事件间的关系。方法采用前瞻性队列研究方法,连续性登记2007年8月1日～2008年2月28日入院的急性缺血性脑卒中患者,入院24h内用专为此课题设计的表格完成资料收集,按照TOAST标准进行病因分型,分析TOAST各亚型与近期炎症事件间的关系。结果近期炎症事件与TOAST亚型间存在显著性差别(P=0.011<0.05)。近期炎症事件能增加大动脉粥样硬化性卒中(OR1.68,95%CI0.82～3.46)和心源性脑栓塞(OR2.07,95%CI1.12～3.80)的发病率。结论炎症事件能增加大动脉粥样硬化性卒中和心源性脑栓塞的发病率,而对小动脉卒中影响不大。
Objective To explore the biological function of miR-181c, and observe the effects of miR-181c on cell proliferation and apoptosis of human brain glioma cells. Methods MiR-181c was synthesized and transfected into the U251 malignant glioma cells by liposome. Cell viability was assessed by cck-8 assay. Cell apoptosis was detected by flow cytometry. Results MiR-181c inhibited U251 cell proliferation in a dose dependent manner, while the control group had no obvious effect on cell growth.Conclusions The chemically synthesized miR-181c plays an important role in cell proliferation and apoptosis of human brain glioma cells, which may be a promising target for glioma gene therapy.
Objective To investigate the implications and effects of IL-10 for the expression of NF-κB in injured spinal cord.Methods The rats(SD,female)randomly divide into experimental group and controlled group.A model of spinal cord injury was completed with an operation microscope.Half hour later,each group had been administered peritoneally before the injured spinal cord was instantly preserved in liquid nitrogen.The nucleoprotein of myeloid tissue was extracted in routine way and quantitated the nucleoprotein.The expression level of NF-κB P65 in myeloid tissue was analyzed with a kit(Trans AMTM NF-κB P65).Results The expression of NF-κB P65 exists in myeloid tissue of the experimental group and the control group,the expression difference was significant(P0.01).The activity of NF-κB P65 in the administered experimental group was to some degree restricted compared with control group,the inhabitation ratio by IL-10 in injured myeloid tissue at different intervals(1,4,6,12 and 24 h)are:12.0%,28.4%,23.8%,15.2% and 17.4%.Conclusions IL-10 inhibit the expression of NF-κB in spinal injury.
Objective To investigate the relationship between carotid atherosclerosis and cerebral infraction subtypes,including lucunar infarct and lacal cerebral infarct.Methods 45 cases of LACI(lacunar infarct),114 cases of local cerebral infarct including partial anterior circulation infarct(PACI)and total anterior circulation infarct(TACI)and 39 cases of non-cerebration infraction(control group)were assessed by color doppler ultrasonography to detect the carotid intima-media thickness(IMT),the numbers and morphology of carotid plaques.Scores of the plaques were calculated.Results Among the three groups,the severest grade of carotid sclerosis and the highest carotid plaque occurrence(97%)were detected in cases of local cerebral infarct.The plaque average in the group of local cerebral infarct was 2.50±1.63(the most).The average in local cerebral infarct group was more than the other two groups(P0.01),next is the lacal cerebral infarct group(P0.01).The carotid plaque composition of the three groups was significantly different(P0.05).In the group of local cerebral infartct,the occurrence of unstable carotid-plaque ipsilateral to cerebral infraction is higher than the others.Conclusions There is a relation between atherosclerosis and cerebral infraction and its subtypes.It should be synthetically caculated by using of ultrasonic detection to carotid.Pharmaceutical intervention should be attached importance to.
Objective To analyze the relationship between obstructive sleep apnea syndrome(OSAS)and cerebrovascular disease(CVD),and investigate the potential etiopathogenesis of OSAS.Methods 50 cases of OSAS in the experimental group and 50 cases of health people in the control group were conducted the Polysomnogram monitor.The blood-lipid(Triglyceride,cholesterol),high-sensitivity C-reactive protein(hs CRP),homocysteine(Hcy),blood viscosity,coagulation function,plasma fibrinogen and ambulatory blood pressure were measured in all the objects of the two groups.Results Compared to the control group,the variable parameters of polysomnogram,such as the time of disordered breathing,the index of disordered breathing,the average time of apnea and the longest time of apnea,the frequency of low oxygen,the index of low oxygen and the time when SaO2 90%,were obviously improved,and the SaO2 and the lowest SaO2 were obviously decreased in the OSAS group.The blood-lipid,the high-sensitivity C-reactive protein,homocysteine,plasma fibrinogen,blood viscosity and blood pressure in the OSAS group were higher than those of the control group(P0.05),otherwise the level of PT(prothrombin time)and APTT(activated partial thromboplastin time)were lower than those of the control group(P0.05).Conclusions OSAS has close relationship with the occurrence of cerebrovascular disease,and it is one of the important risk factors that do not get more attention for a long time.Diagnose and treatment of OSAS has important meaning in the prevention of cerebrovascular disease.
Objective To get the level of monoamine neurotransmittes such as dopamine, noradrenaline etc. in tic disorder patients'serum, and to explore the difference of monoamine neurotransmittes in three tic disorder subgroups. Methods The levels of dopamine amd noradrenaline in 46 tic disorder patients (the case group) and 40 unimpaired child (the control group) were examined using the chemiluminescence technique. Results The level of serum dopamine in the case group was 0.315 μg/ml, and 0.210 μg/ml in the control group. The level of serum noradrenaline in the case group was 0.192 μg/ml, and 0.127 μg/ml in the control group. Both the levels of serum dopamine and noradrenaline in the case group was apparently higher than those in the control group(P0.05); The levels of serum dopamine in the case subgroups were partly 0.239 μg/ml, 0.310 μg/ml and 0.451 μg/ml, respectively. There were significant differences in the three subgroups; The levels of noradrenaline were partly 0.181 μg/ml, 0.193 μg/ml and 0.212 μg/ml, respectively. But there was no significant difference in the three subgroups.Conclusions The abnormality of dopamine and noradrenaline in tic disorder patients is occurred. Furthermore, there were obvious differences in the levels of serum dopamine in all the subgroups, but no difference in the levels of noradrenaline.
Objective To investigated the correlations of plasminogen activator inhibitor 1(PAI-1)-675 4G/5G gene polymorphism, beta fibrinogen-148C/T (Fgβ-148C/T) gene polymorphism and cerebral infarction (CI).Methods PAI-1 -675 4G/5G and Fgβ-148C/T genotypes of 220 cases and 140 health individual controls were identified, and their frequency distribution were analyzed.Results The frequencies of Fgβ-148C/T T allele in CI group and control group were 0.33 and 0.225, respectively (P=0.0 026), and the frequencies of PAI-1 -675 4G/5G 4G alleles in CI group and control group were 0.48 and 0.56, respectively (P=0.037). When considering 5G/5G homozygote as reference, the odds ratio (OR) was 0.52 (95% CI: 0.282～0.958,P=0.027) for 4G/4G homozygote. The risk factor of CI was 0.48 (95% CI: 0.253～0.91 P=0.023) for those with CC and 4G/4G genotypes.Conclusions The findings suggest that Fg β-148T allele are risk factors of CI. PAI-1 -675 4G/4G homozygote is a protective factor for CI. CC genotype strengthens the protective effect of 4G/4G genotype for CI.
Objective To investigate the mental sanitation situation in training-skill-school learners.Methods SCL-90 self-symptom-judgment was employed to testing the mental sanitation situation of 277 training-skill-school learners and comparing it with models of national teenagers.Results The SCL-90 total sharing,positive number and positive-sharing projects of training-skill-school learners are lower than those of the national norm youth group;the girls' body,forced,depression,anxiety,terror and paranoia factor score were significantly higher than those of boys;there were no significant difference of major psychological problems and mental illness in different grades training-skill-school learners;the test results of training-skill-school learners were significant different to those of the national norm youth group.Conclusions The mental sanitation situation of training-skill-school learners is better than that of non-training-skill-school peers.
Objective The first aim is to find out Tetramethyl Pyrazine's(TMP)effect for treating cerebral infarct and to research the effective dose and the relation between dose and effect,by observing infarction areas and neurological severity scale of rats' cerebral infarct caused by cerebral ischemia-reperfusion;and the second aim is to research TMP's function mechanism by observing the changes of the expressions of ED1,TNF-α and IL-1β in the immuno-reacting cells in the infarction region by using immunohistochemistry assay.Methods The cerebral infarct animal model was reproduced by use of modified thread-tie method.Sixty-six SD male adult rats in healthy condition were randomly and averagely divided into eleven groups.Take all the rats of Sham Group 1,Control Group 1,TMP-treatment(Pre-100)Group 1,Treatment(Pre-120)Group,Treatment(Pre-140)Group,and MK801 Group 1 to evaluate whether TMP can decrease the ratio of cerebral infarction area,by analyzing the TTC-stained and formalin fixed brain tissue slices that were originally taken from the above-mentioned killed rats,with Pathology Image Analysis System.Also observe the positive expressions of ED1,IL-1β and TNF-α in the immuno-reacting cells in cerebral infarction brain tissue slice taken from the killed rats of Sham Group2,Control Group 2,Treatment(Pre-100)Group 2,and MK801 Group 2.Results(1)The founding indicates that all the pre-treatment groups and post-treatment group(30 minutes)using TMP can decrease the ratio of cerebral infarction area and improve the neurological deficit after 90-minute-ischemia and 24-hour-reperfusion.(2)Pre-treatment of TMP 100 mg/kg also decreases the immuno-positive expressions of ED1,TNF-α and IL-1β in the cerebral infraction area.Conclusions(1)TMP can decrease the formation of cerebral infarction caused by cerebral ischemia-reperfusion and improve neurological deficits,and(2)TMP may be used to treat cerebral infarct in human,and its effect is possibly related to the activation of microglia,as well as the immuno-positive expressions of TNF-α and IL-1β.
Objective To know the prevalence rate of schizophrenia in Baoding,and the features of gender distribution.Methods From October 2004 to March 2005,stratified multi-stage cluster randomization was used to identify 10073 subjects aged 18 years or over in Baoding.The identify subjects were grouped as the high,moderate and low risk group using an expanded version of the General Health Questionnaire(GHQ-12).Then using the criteria of Diagnostic and Statistical Manual of Mental Disorder(DSM-IV),the subjects were diagnosed according to the fourth edition of Diagnostic and Statistical Manual of Mental Disorder(DSM-Ⅳ)after conducting a Structured Clinical Interview for DSM-Ⅳ-TR Axis I Disorders-Patient Edition(SCID-I/P).Global Assessment Function(GAF)was used to assess the function status.Results 9021 subjects completed the survey.The lifetime and current prevalence rates of schizophrenia were 6.20‰ and 5.42‰,respectively,and 3.93‰ and 3.28 ‰ for male,8.45‰ and 7.55‰ for female.The lifetime and current prevalence rates of schizophrenia were higher in female than in male(P0.01).The married rate of women were significantly higher than that of men(P0.01),while the years of receiving education of women was significantly lower than that of men(P0.01).There was no significant difference in clinical symptoms,age of onset and diagnosis of type of schizophrenia.There were more psychological,social and vocational functional impairment in female than in male(P0.05).There was no significant gender-related difference in mental health service utilization.Conclusions There are significant gender-related differences in prevalence,marriage,education and psychological,social and vocational functional impairment of schizophrenia.This suggests that we should have distinction in the development of treatment and rehabilitation programs.
