Objective To investigate the epidemiological and clinical characteristics of patients infected with hepatitis E virus(HEV) in Chengdu from 2011 to 2013. Methods A retrospective analysis was conducted to investigate 98 patients with HEV infection in our hospital from January 2011 to December 2013 in terms of epidemiological and clinical characteristics. Results Among the 98 patients aged 9 years to 79 years, 63.27% of the cases were young adults(20-50 years old), and male patients numbered more than female ones(1.88∶1). Hepatitis E virus infection occurred throughout the year. The most patients were unemployed or retired residents, workers and peasants, and some were with basic diseases. Examination showed significantly increased level of serum transaminase and bilirubin. After pathogen identified by pharyngeal swab, antiHEV-Ig M and anti-HEV-Ig G double-positive was confirmed in 48 patients. After treatment, 71 patients(71.45%) were cured, 25 patients(25.51%) were improved, and 2 patients died(2.04%). There was an old female patient deferred longer than one year. Conclusions The incidence of HEV is related to age, season, profession and basic diseases. Except for few chronicity, early insulation and effective treatment measures may lead to favourable prognosis.
Objective To study an appropriate murine model for this research, the mice were administrated by gastrogavage with CCl4, D-GalN/LPS, D-GalN/TNF-α and ConA to induce acute liver injury in different group, respectively.Methods The 80 mice were randomly separated from 152 male mice (6-8 weeks). The 80 mice were randomly divided into CCl4+H2O group, CCl4+ Sedum Sarmentosum (SS) group, D-GalN/LPS+H2O group, D-GalN/LPS+SS group, D-GalN/TNF-α+H2O group, D-GalN/TNF-α+SS group, ConA+H2O group, and ConA+SS group (10 mice per group) with the injection of CCl4, D-GalN/LPS, D-GalN/TNF-α and ConA in different groups, and all the mice were administraged by gastrogavage with SS at same time. The survival rate were observed. The 72 mice were randomly divided into Normal group, CCl4+H2O group, CCl4+ Sedum Sarmentosum (SS) group, D-GalN/LPS+H2O group, D-GalN/LPS+SS group, D-GalN/TNF-α+H2O group, D-GalN/TNF-α+SS group, ConA+H2O group, and ConA+SS group (8 mice per group). The mice were sacriifced and plasma alanine aminotransferase (ALT), aspartateaminotransferase (AST) and lactate dehydrogenase (LDH) were measured.Results The survival rate of CCl4+SS group mice was elevated from 55% to 90% (P = 0.0128). After 24 hourschallenge, the serum ALT level was (5500.00± 426.20) U/L, AST (4383.00± 358.00) U/L and LDH (6764.00± 691.30) U/L of CCl4+SS group, lower than CCl4+H2O group ALT (10521.00± 1374.00) U/L, AST (7328.00± 947.80) U/L and LDH (13589.00± 1542.00) U/L (P< 0.05).Conclusions Sedum Sarmentosum has an obvious protecting effect for acute liver injury induced by CCl4in mice.
Objective To evaluate and compare the level of liver inlfammation and ifbrosis in patients with chronic hepatitis B (CHB), and its ability of predicting antiviral efifcacy.Methods We select ALT≥4 ULN and HBV DNA≤6.55 log10 copies/ml as the indicators to predict effective anti-hepatitis B virus. There are 365 patients were recruited in the study, according to different damage of liver inlfammation and ifbrosis, patients were divided into four groups: groupⅠ (the grade of inlfammation<G2 and the stage of ifbrosis< S2), groupⅡ (the grade of inlfammation≥G2 and the stage of ifbrosis< S2), groupⅢ (the grade of inlfammation<G2 and the stage of ifbrosis≥S2), groupⅣ (the grade of inlfammation≥G2 and the stage of ifbrosis≥S2), statistics the correlation of each group with the two ability index (ALT≥4 ULN and HBV DNA≤6.55 log10 copies/ml).Results There were 365 patients divided into groupⅠ (167 cases), groupⅡ(107 cases), groupⅢ (48 cases) and groupsⅣ (43 cases). The groupⅠ have 18 cases with ALT≥4 ULN, groupⅡ of 7 patients, groupⅢ of 11 patients, and 17 patients were included in groupⅣ. There were 38 patients with HBV DNA≤6.55 log10 copies/ml in groupⅠ, groupⅡ of 8 patients, groupⅢ of 54 patients, and 17 patients were included in groupⅣ. The percentage of comply ALT≥4 ULN and/or HBV DNA≤6.55 log10 copies/ml in four groups were 31.7%, 22.9%, 57.0% and 65.1%. There were no statistical difference in groupⅠ and groupⅡ, groupⅢ and groupⅣ by chi-square test, signiifcant differences were observed among any remainder two groups (allP< 0.001).Conclusions The predictive ability of signiifcant liverifbrosis is relatively more prominent than active liver inlfammation.
Objective To investigate the clinical characteristics and risk factors for thyroid disease in patients before and during interferon treatment in viral hepatitis patients.Methods Total of 185 patients with chronic hepatitis B and chronic hepatitis C who received interferon treatments were enrolled. All patients took one year follow-up. Clinical data was analyzed to elucidate the relationship between IFN therapy and thyroid dysfunction.Results The 98 cases of chronic hepatitis B (CHB group) and 87 cases of chronic hepatitis C patients (CHC group) were enrolled. The 27 patients (14.6%) had thyroid dysfunction before IFN treatment. Less male patients (3.5%, 4/115) had thyroid dysfunction before IFN therapy than female patients (32.9%, 23/70). More CHC patients 23.0% (20/87) had thyroid dysfunction before IFN therapy than CHB patients (7.1%, 7/98). And more CHC patients were TPOAb positive before IFN treatment than CHB patients. More female patients (80.0%, 56/70) had thyroid dysfunction during IFN therapy than male patients (16.5%, 19/115). More CHC patients (66.7%, 58/87) had thyroid dysfunction during IFN therapy than CHB patients (17.3%, 17/98). And more CHC patients were TPOAb positive during IFN treatment than CHB patients. Logistic regression indicates that female, chronic hepatitis C and TPOAb positive are independent risk factors for thyroid dysfunction.Conclusions Female CHC patients with TPOAb positive are more likely to have thyroid disease.
Objective To analyze the characteristics of the occurrence of nosocomial infection in patients with fulminant hepatitis and help to effectively prevent the occurrence of hospital infection. Methods We used SPSS 13.0 statistical software for January 2009 to December 2013, 386 cases of hospital infection in severe hepatitis cases were retrospectively analyzed. Results There were 386 cases and 71 cases of hospital infection occurred in patients with severe hepatitis, hospital infection rate was 18.39%. The infection is given priority to with abdominal cavity infection, respiratory tract infection, intestinal infection. Pathogens to pneumonia Klebsiella bacillus, E. coli and the most common white candida. Hospital infections occur with age, length of hospital stay, invasive operation and application of antimicrobial agents positive correlation(P 0.05). Hospital infection is given priority to with abdominal cavity infection, respiratory infections and gastrointestinal infection, the case fatality rate of 71.83%. Conclusions Fulminant hepatitis is high incidence of hospital infection, hospital infection of high-risk groups and lead to the risk factors of death.
ObjectiveTo investigate the effect of clinical surgical techniques of congenital choledochal cyst on improving liver function and its long-termed effect.MethodsWe selected 41cases, including 23 males and 18 females, aged 1.5-14 years old, who are suffering from congenital choledochal cyst in Setemper 2009 to December 2013. All the patients were operated on with complete cyst excision combined with Roux-en-Y hepaticojejunostomy after diagnosis by imaging tests. The serum indexes of liver function, total bilirubin (TBil), direct bilirubin (DBil), alanine aminotransferase (ALT), aspartate aminotransferase (AST) before operation were tested to compared with that ofone week after operation.ResultsThe result of experiments shows that 27 cases of 41 patients were higher than normal in TBil and DBil, which decreased signiifcantly after the procedure(P<0.01), the difference means something in statistics. In addition, 14 cases are within the range of normal reference value, their postoperative TBil and DBil shows no signiifcant difference (P>0.01). Their preoperative ALT and AST indexes were higher than the normal value, which signiifcantly decreased after the operation. There are signiifcant differences between preoperative and postoperative surgery (P<0.01). Thirty-seven cases which are visited regularly have good prognosis. Two patients suffered from stone formation in bile duct with cholangitis,and their symptoms were relieved after reoperation of lithotomy through original anastomosis, one of them received Partial resection of the left liver with the left lateral lobe of liver ifbrosis. Among them there were two casewith early postoperative complication, one case acute pancreatitis and the other case of adhesion ileus, both of them were relieved after conservative treatment.ConclusionsWe draw a conclusion that complete cyst excision combined with Roux-en-Y hepaticojejunostomy is the best surgical method to cure patients suffering from congenital choledochal cyst.
Objective To analysis and explore the clinical features of hepatic veno-occlusive disease (HVOD) induced by gynura segetum in the patients with alcoholic liver cirrhosis.Methods The data was collected and analysed from 4 patients hospitalized in our department from October 2012 to June 2014. The diagnosis of HVOD for all the patients was made by the drug use history, typical clinical manifestation, biochemical and iconographic examination, CT or MRI.Results The results showed that this group of cases has the following clinical features: all patients are male and the age was elder than 45 years old; all patients with history of long-term use of gynura segetum, one of Chinese medical herbs, because of the suffering orthopaedic disease such as fractures, lumbago, lumbar disc. Before the occuring of HVOD paroxysm, all of the patients had basis of alcoholic liver cirrhosis, with the average of 10 years of alcohol-drinking. All the cases manifested the typical clinical symptoms and sign of HVOD, but without hepatomegaly. The diagnosis of HVOD in all of patients was ifnally conifrmed by both of CT or MRI and Inferior vena cava angiography. There was a positive relationship between the severity of the disease and the total dose of gynura segetum.Conclusions Long-term alcohol drinking may be an important risk factor for the severity of HVOD induce by gynura segetum. It is the ifrst report of hepatic veno-occlusive disease induced by gynura segetum on the basis of alcoholic liver cirrhosis.
Objective To observe effect of the degrees of fatty liver disease in rat with type 2 diabetes mellitus and nonalcoholic fatty liver disease was inhibited by Gypenosides and Ginkgo Biloba Extract Mixture. Methods Total of 40 SPF male SD rats, body mass 220-250 g, were randomly divided into blank control group, model group with type two diabetes mellitus and nonalcoholic fatty liver disease. After eight weeks the NAFLD model in rats was maked, model group were divided into three groups: treatment group were perfused with 500 mg/(kg·d) GPS and 0.1g/(kg·d) ginkgo biloba extract mixture, control group were perfused with 500 mg/(kg·d) GPS, model group were perfused with the same volume of water, and high fat diet at the same time, the experimental period was six weeks. The experimental period was 14 weeks. Blood sugar, triglycerides, total cholesterol(TC), ALT, AST in the plasma in rat was test. It was tested that triglycerides in the liver tissue. The Liver tissue was detected by pathology. Results BS levels in plasma: blank control group(5.50 ± 0.51) mmol/L, model group(18.76 ± 4.20) mmol/L, treatment group(10.78 ± 3.389) mmol/L, control group(14.62 ± 3.32) mmol/L, treatment group and control group was lower than model group, there was a significant difference(P 0.01), treatment group was lower than control group, there was a significant difference(P 0.05). TG levels in plasma: blank control group(0.81 ± 0.11) mmol/L, model group(1.29 ± 0.14) mmol/L, treatment group(0.90 ± 0.09) mmol/L, control group(1.09 ± 0.10) mmol/L, treatment group and control group was lower than model group, there was a significant difference(P 0.01), treatment group was lower than and control group, there was a significant difference(P 0.05). TC levels in plasma: blank control group(1.39 ± 0.13) mmol/L, model group(3.69 ± 0.27) mmol/L, treatment group(2.59 ± 0.19) mmol/L, control group(3.11 ± 0.18) mmol/L, treatment group and control group was lower than model group, there was a significant difference(P 0.05), treatment group was lower than control group(P 0.05). ALT levels in plasma: blank control group(35.12 ± 3.34) U/L, model group(60.68 ± 5.12) U/L, treatment group(42.13 ± 4.99) U/L, control group(50.12 ± 4.68) U/L, treatment group and control group was lower than model group, there was a significant difference(P 0.05), treatment group was lower than control group(P 0.05). AST levels in plasma: blank control group(81.15 ± 7.14) U/L, model group(168.12 ± 10.49) U/L, treatment group(112.23 ± 10.12) U/L, control group(139.12 ± 11.68) U/L, treatment group and control group was lower than model group(P 0.01), treatment group was lower than control group(P 0.01). TG levels in liver tisue: blank control group(30.26 ± 2.48) mg/g, model group(228.46 ± 8.48) mg/g, treatment group(153.12 ± 9.98) mg/g, control group(196.24 ± 9.78) mg/g, treatment group and control group was lower than model group, there was a significant difference(P 0.05), treatment group was lower than control group(P 0.05). Liver pathology: blank control group was normal liver tissues. Model group was severe fatty liver disease. Treatment group and control group was moderate to severe fatty liver disease, and treatment group was lighter than control group. Conclusions The degree of T2 DM and nonalcoholic fatty liver disease in rats was inhibited by gypenosides and ginkgo biloba extract mixture, through blood sugar and lipid metabolism adjusted, and reduce the liver tissue TG deposition, protecting liver cells.
Objective To observe the clinical effect of entecavir (ETV) combined with Liuweiwuling tablets on hepatic cirrhosis.Methods Total of 122 hepatic cirrhosis patients were randomly divided into treatment group and control group: the control group (60 cases) were treated with ETV (0.5 mg/d) for 24 weeks; while the treatment group (62 cases) were treated with Liuweiwuling tablets (1.5 g once, three times a day) and ETV (0.5 mg/d) for 24 weeks. The liver function, HBV DNA and liver ifbrosis markers (HA, LN, PC-Ⅲ, CIV) between the two groups were compared after treatment.Results The liver function, HBV DNA and liver ifbrosis markers (HA, LN, PC-Ⅲ, CIV) in the treatment group were better than those in the control group (P< 0.01).Conclusions ETV combined with Liuweiwuling tablet therapy is an effective treatment and more effective than that with ETV only for patients with hepatic cirrhosis.
Objective To observe the clinical effect and safety of Jianpiqinghua method combined with adefovir dipivoxil (ADV) on treating chronic hepatitis B (CHB).Methods Total of 158 cases with CHB were randomly double-blind divided into treatment group (n = 80, using ADV combined with Jianpiqinghua apozem) and control group (n = 78, only using ADV). Two groups were given conventional liver protection, suit the case and supportive treatment. The treatment lasted 24 weeks. Clinical symptoms, liver function and HBV DNA changes were observed before and treatment in patients.Results After treatment, the clinical symptoms, liver function and HBV DNA undetectable ratio of treatment group were better than that in control group (P<0.05).Conclusions Jianpiqinghua method combined with ADV is safe and effective treatment on CHB.
Objective To investigate the clinical characteristics of drug-induced liver injury (DILI) caused by Traditional Chinese Medicine (TCM) or Western medicine.Methods Total of 78 cases with DILI were collected in Jiangsu Province Hospital of TCM during the period from 2008 July to 2014 July, then the clinical characteristics of DILI caused by TCM or Western medicine as well as the differences between the indexes of laboratory were analyzed retrospectively.Results The mainly patients were middle-aged and elder. The number of female patients was twice more than that of male ones, and the most common is liver cell type (about 74.49%). Further analysis found that DILI caused by TCM account for about 39.74%, while the Western medicine ones were about 60.26%. There were no differences in age, gender, the onset of disease, clinical classiifcation, and clinical immunological characteristics between DILI induced by TCM and Western medicine (P>0.05), but showed signiifcant statistical difference in clinical efifcacy between such two drug types (P<0.05), the prognosis was poor in TCM-induced compared to the Western medicine ones. During the initial onset time, hepatic function indexes such as the levels of TBil, ALT, AST, TBA of TCM-induced DILI were signiifcantly higher compared to the Western medicine ones (P<0.05). However, the levels of TP, ALB, ALP, GGT and PT induced by two types of drug showed no signiifcant differences (P>0.05). The hepatic function of TCM or Western medicine-induced DILI showed signiifcantly improved after treatment for two weeks compared to that of pre-treatment (P<0.05) except the level of PT (P>0.05). The results also showed that only TBA was higher in DILI patients induced by TCM compared to that of the Western medicine (P<0.05).Conclusions The hepatotoxicity and the degree of hepatocyte necrosis-induced by TCM is higher than that of the Western medicine, also its prognosis is worse and recovery is slower compared to the Western medicine ones.
ObjectiveTo observe of liver stagnation and spleen deficiency, bruising internal resistance of clinical efficacy of hepatitisC liver cirrhosis treated by combination of traditional Chinese and Western medicine.MethodsWe collected 136 hepatitis C patients with cirrhosis in our hospitalfrom January 2012 to February 2014 and make a retrospective analysis of clinical data.Thispatients randomly,equally divided into treatment group androutine group.Routine group treated with conventional Western medicine therapy, whiletreatment group add with Sophora reconciliation poison liver decoction treatment on the basis of routine group,and then observed the clinical efifcacy of two groups of patients.ResultsTreatment group total effective rate reached 82.35%,routine group 60.29%, the clinical efifcacy of the treatment group was signiifcantly better than the routine group (P< 0.05), and treatment group curative effect wasmorestable aftersix months.Conclusions The combination of traditional Chinese and Western medicine treatment of hepatitisC cirrhosis can effectively improve patient quality of life, gain signiifcant clinical curative effect, is worthy of popularization and application.
Objective To discuss the prevention and nursing of complications on 73 patients with liver failure. Methods On the basis of elementary and support treatment, with the help of doctor, we take steps to prevent and nurse possible complications in the 73 liver failure patients. At the same time, we give guidance of health education for patients' psychological change. Results There were 52 cases(71.23%) survived, 21 cases(28.77%) died. Conclusions With the help of doctor, we have made early prevention and intervention on complications of liver failure in 73 cases, attached importance to the psychological change of patients and their relatives. We have helped patients to restore confidence, reduce complications and reduce mortality.
Objective To investigate the protective effect of PXR in CCl4-induced liver injury in rat. Methods Forty eight Sprague-Dawley male rats were randomly divided into four groups: control group(without treatment); model group, which was treated with CCl4 to induce liver injury; empty vector group, which was intravenously injected with lentiviral vector three days before liver injury; PXR recombinant lentivirus group was intravenously injected with PXR recombinant lentivirus three days before liver injury. The degree of liver injury was evaluated by HE staining and levels of serum AST and ALT. The expression of PXR, NF-κB, IL-1, IL-2 and TNF-α in liver were assayed by RT-PCR and Western blot. Results After intravenous injection with PXR recombinant lentivirus, fibrosis and serum AST and ALT in rat with liver injury reduced significantly. The expression of PXR in liver increased significantly. On the contrary, the expression of NF-κB, IL-1, IL-2 and TNF-α in liver decreased significantly. Conclusions PXR plays a protective role in CCl4-induced liver injury in rat. It may through inhibit the expression of NF-κB, further to down-regulate the expression of IL-1, IL-2 and TNF-α, which provides a new way for treatment of liver injury.
ObjectiveTo observe the effect of interventional therapy guided by ultrasound in AIDS patients with liver abscess.Methods Clinical dataabout17 patients of AIDS with liver abscesses(31 lesions) who underwent interventional therapy guided by ultrasound in our department from October 2009 to January 2014 were retrospectively analyzed.ResultsThere are 31 abscesses among the 17 patients, single abscess in 9 cases,andmultiple abscess in 8 cases. Wepunctured16 abscessesandcatheterized 15 abscesses with a success rate of100%,the range of drainagetime was6-30 days. There was no medical staff exposed infection and deifnite complication with patients. All the patients were cured. One patient withanew abscess was punctured again after3months.Conclusions Interventional therapywith ultrasound guided is safe and effective for AIDS patients with liver abscess, also is the preferred treatment.
Objective To analyze the epidemiological characteristics of the people with early primary liver cancer (PLC) for providing a reference for the prevention.Methods Total of 850 patients with early PLC were used to screen the epidemiological characteristics, such as age, TNM stage, occupation, pathology type, tumor size and residential areas by descriptive analysis.Results In the 850 patients, hepatocellular carcinoma cases were 417 (49.18%), 30 cases (3.53%) were intrahepatic cholangiocarcinoma, 8 cases (0.94%) were adenocarcinoma, 13 cases (1.53%) were the other pathology types and 381 cases (44.82%) were pathology not speciifcally. The patients with early PLC in urban were 282 and that in rural were 568. The difference showed statistical significance (χ2= 11.275, 41.995;P = 0.001,P<0.001) among the different groups in year of diagnosis (2004-2008 vs. 2009-2013) and occupation, but there were not statistical signiifcance in gender, age, tumor size, TNM stage and pathology types (χ2= 0.082, 0.613, 3.184, 1.803, 0.376, allP> 0.05).Conclusions The rural people are susceptibility to PLC than urban, and the main pathology types are hepatocellular carcinoma in this study. Early PLC patients increased signiifcantly in recent years, new detection technology related to the effective prevention and control measures should be taken at the same time.
Objective To establish a diagnosis model combining four serum markers of hepatic fibrosis(HA, LN, PⅢ NP, CⅣ) and assess the diagnostic performance of model aimed to discriminate between patients with and without significant hepatic fibrosis in patients with hepatitis B. Methods Total of 485 patients with hepatitis B were randomly divided into an estimation group(324 cases) and a validation group(161 cases). The serum levels of HA, LN, PⅢ NP and CⅣ were measured by radiommunoassay in all patients and biopsy was used as the gold standard. A binary logistic regression model was established combining four serum markers and applied to the validation group to test its accuracy. The diagnostic value of the model was assessed by the receiver operating characteristic(ROC) curves. Results Binary logistic regression identified HA, PⅢ NP and CⅣ as independent predictors of fibrosis. We constructed a model named FSM combining HA, PⅢ NP and CⅣ that proved useful to identify patients with or without significant hepatic fibrosis in patients with hepatitis B. FSM = 1.56 × ln(HA) + 0.92 × ln(PⅢNP) + 1.9 × ln(CⅣ)- 8.18. The area under the ROC curve(AUC) was 0.85 for predicting significant fibrosis. In validation group, the AUC was also 0.85 for predicting significant fibrosis. Using optimized cutoff values, the sensitivity and negative predictive value of predicting the absence of significant fibrosis(FSM 10.8) were 88.31% and 69%, while the specificity and positive predictive value of predicting the presence of significant fibrosis(FSM ≥12.6) were 93.55% and 95.3%. Comparing the FSM diagnostic model and HA, the Youden's index, positive likelihood ratio, sensitivity, specificity and accuracy of FSM model were higher than those of HA, and AUC had significant difference between the two(Z = 2.06, P 0.05). Conclusions The FSM model established in this study improved the diagnostic performance. It can make the 65%-70% patients without significant hepatic fibrosis to avoid liver biopsy. As a noninvasive method, it can be employed for monitoring the progression of hepatic fibrosis.
Objective To detect the serum levels of PTX3 in patients with non-alcohol fatty liver disease(NAFLD) and to analyze the relationship between serum PTX3 and oxidative stress, insulin resistance(IR) in non-alcohol fatty liver disease.Methods Enzyme linked immunosorbent assay (ELISA) was applied to detect the serum PTX3 in 41 NAFLD patients complicated with IR, 93 NAFLD patients without IR and 140 healthy controls. Besides, metabolic parameters clinical data was collected. Correlation analysis was performed to explore the relationship between serum PTX3 and oxidative stress, insulin and IR. The multivariate logistic regression analysis was applied to analyze the risks factors for NAFLD patients complicated with IR. Receiver operating characteristic (ROC) analyses were performed to explore the diagnosis value of PTX3 in IR of NAFLD patients.Results The average PTX3 in serum concentration in non-alcohol fatty liver disease patients was signiifcantly higher than that in healthy controls [(3.2 ± 1.2) ng/ml vs. (2.5 ± 0.6) ng/ml,P = 0.000]. The concentration in NAFLD patients complicated with IR was also higher than that in NAFLD patients without IR[(4.5 ± 1.2) ng/ml vs. (2.0 ± 0.6) ng/ml,P = 0.001]. Correlation analysis indicated that PTX3 was positively correlated to HOMA-IR (r = 0.236, P = 0.001), fasting plasma glucose (r = 0.312,P = 0.012), MDA (r = 0.004,P = 0.001), and negatively correlated to GSH (r = -303,P = 0.001). Multiple logistics regression analysis showed that PTX3 was an independent protective factor for non-alcohol fatty liver disease with IR (OR 1.45, 95% CI :1.13-1.912,P = 0. 041). The area under the ROC curves for PTX3 to distinguish IR from NAFLD was 0.712 for PTX3, with a cut-off value of 3.86 ng/ml (sensitivity:51.9%; speciifcity: 94.5%;P = 0.012). In addition, individuals in non-alcohol fatty liver disease patients with higher 3.86 ng/ml PTX3 were associated with increased risk of IR (OR = 3.67, 95%CI: 3.19-13.36,P = 0.000). Multiple stepwise linear regression analysis showed that GSH, hs-CRP and HOMA-IR were independent risk factors for PTX3.ConclusionsPTX3 is closely related to oxidative stress and insulin resistance in NAFLD. It is useful for disease surveillance by monitoring PTX3.
Objective To research the effect factors of postpartum hemorrhage of puerpera with liver diseases, and to propose corresponding preventive measures regarding to these relevant risk factors.Methods Total of 96 cases of puerpera in our hospital between January 2010 and December 2012 were selected, from which, 98 cases postpartum hemorrhage of puerpera with liver diseases were and were selected as experimental group, meanwhile 96 cases puerpera without postpartum hemorrhage were selected as control group. Then all the possible factors that may contribute to postpartum hemorrhage of puerpera were compared and analysed. Results Univariate analysis showed that postpartum hemorrhage of puerpera with liver diseases were related to that total protein, packed cell volume (Hct), blood platelet (PLT), albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood transfusion, hemoglobin. Multivariate analysis showed that the increasing of alanine aminotransferase (ALT) was independent risk factor of postpartum hemorrhage of puerpera with liver diseases, while the increasing of PLT was independent protective factor of postpartum hemorrhage of puerpera with liver diseases.Conclusions ALT and PLT were independent risk factors of postpartum hemorrhage of puerpera with liver diseases. These risk factors should be targeted prevention and control measures.
