Objective To investigate the effects of bisphenol A(BPA)and its substitutes on the expression of key genes involved in the proliferation and migration of breast cancer cells through bioinformatics analysis and in-vitro experiments.Methods The differ-entially expressed genes(DEGs)of human breast cancer MCF-7 cells induced by BPA and its substitutes were determined through the GSE number in the Gene Expression Omnibus database GSE85350.Functional enrichment analysis and visualization were performed on the DEGs using clusterProfiler and enrichplot packages in R 4.2.3,followed by identifying hub genes and protein-protein interaction network construction conducted through the maximal clique centrality(MCC)algorithm.The expression of key genes in human breast cancer samples was further verified by Gene Expression Profiling Interactive Analysis.Finally,the mRNA expression levels of the key DEGs were verified using real-time quantitative polymerase chain reaction.Results The gene ontology analysis of DEGs revealed that 27 DEGs in the BPA exposure group were mainly enriched in spindle organization and myotube differentiation;65 DEGs in the BPF ex-posure group were mainly enriched in steroid response and positive regulation of cell-substrate adhesion;and 185 DEGs in the BPS ex-posure group were enriched in organelle fission and nuclear division.Twenty-four BPB-induced DEGs,23 BPAF-induced DEGs,and 101 shared DEGs were not enriched.According to the protein interaction network and the core genes identified from shared DEGs with the MCC algorithm,exposure to BPA and its substitutes could influence the expression of genes associated with the proliferation and mi-gration of human breast cancer MCF-7 cells,including CD44,PPARG,EPAS1,CDK6,PGR,RET,CDKN2B,LDHA,ALDH1A3,and SALL4.Conclusion Exposure to BPA and its substitutes can promote the mRNA expression of the CD44,PGR,RET,and LDHA genes,and inhibit the mRNA expression of the PPARG,EPAS1,CDK6,CDKN2B,ALDH1A3,and SALL4 genes.
Objective To investigate the effects of perfluorooctane sulfonate(PFOS)exposure on embryonic development and its possible mechanism by constructing a model of PFOS zebrafish infection.Methods The PFOS concentration gradients(0,0.02,0.2,2,and 20 μmol/L)were established based on human internal exposure levels,and exposed to zebrafish embryos for 120 hours post fertilization,then the basic indicators of zebrasish(hatching rate,malformation rate,mortality rate,heart rate,and motor ability)were measured.The global metabolic changes of zebrafish embryos exposed to PFOS were measured through non-targeted metabolomics technology.The expression of differential metabolic enzymes and proteins was determined by real-time quantitative PCR(RT-qPCR)and western blot.Results Exposure to 20 μmol/L PFOS significantly increased the malformation rate(P＜0.05),heart rate(P＜0.05),and motor abnormalities(P＜0.05)of zebrafish embryos.The metabolomics analysis showed that in the 20 μmol/L PFOS ex-posure group,the levels of glucose-6-phosphate(Glu-6-P),N-acetylglucosamine(GlcNAc),and N-acetylglucosamine-6-phosphate(GlcNAc-6-P)were significantly increased,indicating the hyperactivation of hexosamine biosynthesis pathway(HBP).RT-qPCR demonstrated that the gene expression levels of HBP-related key metabolic enzymes(slc2a1b,hk1,and gfat1)were significantly up-regulated in 20 μmol/L PFOS group.Western blot showed that there was a significant difference in the global O-linked N-acetylglu-cosaminylation(O-GlcNAc)level between the 20 μmol/L PFOS group and the control group.Conclusion PFOS exposure may inter-fere with HBP to mediate change of O-GlcNAcylation level,resulting in increased malformation and motor abnormalities in zebrafish em-bryos,suggesting that PFOS is toxic to embryonic development.
The number of swimming pools for infants and young children has been growing rapidly in China in recent years.How-ever,due to the lack of sanitary management norms or standards,there are hidden health and safety risks in baby swimming places.This paper introduces the current situation of the baby swimming industry,the characteristics of baby swimming places,and the existing health and safety problems,focusing discussion on the health design requirements,and sanitary quality requirements for water quality,indoor air,and public articles,as well as management requirements for baby swimming places,and also provide suggestions on sanita-tion management of baby swimming places.
Objective To investigate the drinking water quality detection capability of centers for disease control and prevention(CDCs)in China in 2022,and to provide a reference for promoting construction of water quality detection capability in CDCs.Methods Data on water quality detection capability of CDCs at all levels in China in 2022 were collected to analyze the detection ca-pabilities of CDCs for all indices(106 items)and conventional indices(42 items)in the Standards for Drinking Water Quality(GB 5749-2006)at different levels and in different regions.The Kruskal-Wallis H test was performed to compare the detection capabilities of CDCs at different levels and in different regions.Results The M(P25,P75)values of detection capabilities for all indices of CDCs at provincial,provincial capital,prefecture,and county/district levels were 106(104,106),106(104,106),94(60,104),and 37(33,42),respectively,showing a significant difference(χ2 =632.56,P＜0.001).The M(P25,P75)values of detection capabili-ties for conventional indicators were 42(42,42),42(42,42),40(40,42),and 36(32,40),respectively,showing a significant difference(χ2 =396.76,P＜0.001).The pairwise comparative analysis showed that the detection capabilities of CDCs for all indices and conventional indicators were all significantly lower at county/district levels than those at provincial,provincial capital,and prefec-ture levels(P＜0.001 after adjustment).There were no significant differences in the detection capabilities of CDCs for all indices and conventional indices at provincial and provincial capital levels among different regions(χ2 were 3.67,4.04,8.69,5.42,respective-ly,P＞0.05).There were significant differences in the detection capabilities of CDCs for all indices and conventional indices at pre-fecture and county/district levels among different regions(χ2 were 50.16,36.16,177.36,154.56,respectively,P＜0.001).The pairwise comparison showed that the detection capabilities of East China were highest,and the detection capabilities of CDCs in North-west China were significantly lower than those of other regions(P＜0.001 after adjustment).The detection capability was the lowest for gross alpha radioactivity and gross beta radioactivity among conventional parameters,and weakest for Giardia lamblia,Cryptosporidium,microcystin,and glyphosate among non-conventional parameters.Conclusion After more than ten years construction,there has been an improvement in the water quality detection capability of the CDC system compared with 2008,but still with a gap between the cur-rent detection capability and the requirements.The detection capability of CDCs at county/district levels and in Northwest China is rel-atively weak,which should be strengthened in the future.
Based on the World Cancer Report 2020 released by the International Agency for Research on Cancer(IARC)of World Health Organization(WHO),combined with the literature on environmental pollution and cancer prevalence,this paper introduces the latest information of the global cancer incidence and death rates,and summarizes the types and hazards of carcinogenic factors in air,water,and soil.
Siloxanes,as a group of emerging contaminants that have attracted worldwide attention,have been widely used in the fields such as silicone rubber products,electronic products,healthcare products,personal care products,food additives,cookwares,medical equipments.Siloxanes and their derivatives pose potential risks to ecological environment and human health due to their char-acteristics of high persistence,bioaccumulation,and biotoxicity.China is the largest producer of siloxanes in the world.It is necessary to establish efficient and accurate analytical method to assess the occurrence characteristics of siloxanes in different media and their health risks to people,so as to provide key technical support for the management of emerging contaminants in China.This article sum-marizes the pretreatment method for siloxanes and their derivatives in different matrices,and reviews the latest research findings of in-strumental analysis method from the perspectives of targeted analysis and non-targeted screening in China and globally,in order to pro-vide important references for the detection and health risk assessment of siloxanes and their derivatives in different types of substrates such as environmental matrices and human biological samples.
The Examination Method for Public Places― Part 4:Microorganism on a Surface of Public Articles(GB/T18204.4-2013)has been widely used in the process of health management and supervision in public places and has played an important role since its release on December 31,2013.However,with socio-economic development,some of the equipment,reagents,experimental process,and result interpretation in the standard can no longer meet the actual work needs in public places.Based on the principles of scientificalness,practicability,uniformity,and standardization in standard formulation,this paper analyzed the original standard and puts forward some suggestions for revision.
Objective To estimate the acute effect of short-term exposure to atmospheric fine particulate matter(PM2.5)on death due to nervous system disease in Jiangsu Province of China.Methods Data were collected from environmental monitoring,meteoro-logical monitoring,and resident death surveillance in 13 municipalities of Jiangsu Province from 2016 to 2021.A generalized additive model was performed to evaluate the association between daily PM2.5 mass concentration and death due to nervous system disease,and a meta-analysis with a multivariate random effects model was performed to merge the effective values of PM2.5 and risk of death in multi-ple cities.Results In Jiangsu Province from 2016 to 2021,the daily mean mass concentration of PM2.5[M(P25,P75)]was 43.1(2.0,333.6)μg/m3,and the average daily number of deaths due to nervous system disease[M(P25,P75)]was 32(11,75).The single-pollutant model showed that PM2.5 at lag07 day had the greatest impact on daily deaths due to nervous system disease,and for every 10 μg/m3 increase in PM2.5 concentration,the daily number of deaths due to nervous system disease was increased by 1.26%(95%CI:0.57%,1.95%).The effective value was still statistically significant in the double-pollutant model.Female and the elderly aged≥65 years were more sensitive to acute death due to nervous system disease caused by PM2.5.The exposure-response relationship between PM2.5 and death due to nervous system disease was non-linear without threshold.Conclusion Short-term exposure to PM2.5 can result in an increase in daily deaths due to nervous system disease,and therefore,the potential threat of PM2.5 on acute death should not be neglected.
The emergence of large-scale centralized isolation sites is an important measure for China to cut off the transmission routes and control potential sources of infection under the special circumstances of the implementation of coronavirus disease 2019 a-gainst Class-A infectious diseases in China.Based on the characteristics and operation management mode of large centralized isolation sites,this paper reviews and sorts out risk points involved in personnel allocation and responsibilities,management system,material support,food safety assurance before putting into operation,ventilation and air conditioning,sewage and garbage disposal,biological vector control,elevator use and fire safety,and emergency response during operation.Suggestions were also provided on targeted health management requirements and measures.
Objective To investigate the pollution characteristics of metals/metalloids in household dust in the cities,China,and to provide a scientific basis for the prevention and control of metal/metalloid pollution in household dust.Methods According to the daily life scenarios of Chinese residents,samples of household dust were collected from 152 households in five cities in China in 2018(once in warm season and once in cold season),and the content of 19 kinds of metals/metalloids in the samples were measured by ICP-MS.Rank-sum test was performed for comparison between different types of cities,different wind direction areas and different sea-sons.Results A total of 185 household dust samples were measured,and the content of 19 metals/metalloids in the samples ranged from 0.01 μg/g(mercury)to 17 105.42 μg/g(titanium).The content of titanium,barium,and manganese were the highest,with median concentration of 3 351.62,610.66,and 566.50 μg/g,respectively.The median concentration of cadmium,copper,boron,barium,nickel,and arsenic was 3.04,1.42,1.37,1.35,1.28,and 1.26 times of the soil background values in China,respective-ly.The contents of chromium,arsenic and antimony in the household dust of Lanzhou,barium,vanadium,chromium,cobalt,molyb-denum and thallium of Mianyang,and vanadium and mercury of Shijiazhuang were higher in the cold season than those in the warm season(Z ranged from-2.979 to-2.042,P＜0.05).The cobalt and molybdenum in the household dust of Luoyang,the barium,va-nadium,chromium,cobalt and molybdenum in Mianyang,the vanadium,chromium,nickel and lead in Shenzhen,and the selenium in Shijiazhuang were higher in the downwind area than those in the upwind area(Z ranged from-3.071 to-1.985,P＜0.05).The first-tier cities had a significantly higher contents of zinc of 94.46 μg/g(Z=7.468,P=0.024),nickel of 53.04 μg/g(Z=14.373,P=0.001),and cadmium of 0.47 μg/g(Z=15.654,P＜0.001),and the second-tier cities had a significantly higher contents of cop-per(46.80 μg/g)and vanadium(84.32 μg/g)(Z were 67.062 and 59.764,respectively,P＜0.001),while the higher contents of mercury,antimony,beryllium,cobalt,chromium,manganese,and barium were observed in the third-tier cities.Conclusion Nine-teen kinds of metals/metalloids were detected in the household dust,and the contents of cadmium,copper,boron,barium,nickel and arsenic exceeded the soil background value by a higher multiple.The overall trend of metal/metalloid content was higher in the cold season than that in the warm season,and higher in the downwind areas than that in the upwind areas.The contents of mercury,antimo-ny,beryllium,cobalt,chromium,manganese,and barium in household dust were higher in the third-tier cities.There were relatively high contents of copper and vanadium in the second-tier cities and relatively high contents of cadmium,nickel,and zinc in the first-tier cities.
2023年11月18～21日,由中国化学会环境化学专业委员会和中国地质大学(武汉)主办的第十二届全国环境化学大会在湖北武汉召开.这次会议以"健康环境、宜居地球"为主题,围绕"双碳"目标、环境与健康、以及水、土、气、固废相关的环境分析、界面过程、生态毒理效应与健康风险等多个领域设置94个分会场,邀请包括国内外33位院士在内的近万名专家学者参会.
目的 了解深圳市罗湖区生活饮用水中Fe、Cd、Al、Mn、Cu、Zn、As、Se、Hg、Pb和Cr(VI)11种元素的浓度特征,并评估其健康风险.方法 利用简单随机抽样在深圳市罗湖区4个水厂采集出厂水、末梢水和二次供水样品共162份,按照《生活饮用水检验方法》(GB/T 5750-2006)分析水样中Fe、Cd、Al、Mn、Cu、Zn、As、Se、Hg、Pb和Cr(VI)11种元素浓度;运用重金属水质污染评价指数(HPI)和重金属评价指数(HEI)评估Fe、Cd、Mn、Cu、Zn、Hg、Pb和Cr(VI)8种重金属污染水平;参考《化学物质环境健康风险评估技术指南》(WS/T 777-2021)评估检出元素的致癌健康风险(CR)和非致癌健康风险(HQ);采用Monte Carlo模拟方法进行不确定性和敏感性分析.结果 对测得的饮用水11种元素浓度进行分析,结果表明梧桐山水厂2019年春季1个出厂水和3个末梢水样品中的Al浓度超过国家标准(0.2 mg/L),4个样品的浓度分别为0.25、0.28、0.24和0.24 mg/L;除Al外,其他元属在所有样品中均未超标;Fe、Cd、Mn、Cu、Zn、Hg、Pb和Cr(VI)HPI和HEI分别为0.1034和0.2631,处于低污染水平;Fe、Al、Mn、Cu、Zn、As和Se的HQ均远低于1,这7种元素非致癌健康风险可以基本忽略;As的CR为3.07×10-5±1.32×10-5,未超过最大可接受风险水平1×10-4;敏感性分析结果显示As浓度是最敏感参数.结论 罗湖区生活饮用水中部分Al超标,应作为保障饮用水安全的重点关注对象;饮用水中11种元素的健康风险较低,可以安全饮用.
目的 探讨太原市PM10暴露对学生呼吸系统症状的急性影响.方法 收集2017—2019年太原市空气污染国控监测点1 km范围内所有中小学及幼儿园的学生呼吸系统症状监测数据,按照发病日期、学校所对应的空气污染物监测点匹配相应污染物浓度,应用时间分层病例交叉研究设计,选择条件Logistic回归模型,评估PM10暴露对学生呼吸系统症状发生的滞后效应和累积效应.结果 研究期间太原市PM10每日浓度中位值为122μg/m3,超过国家环境空气质量二级标准(150μg/m3)307 d,占28％.发病当天至前1天(lag0～lag1 d)、前3天至前7天(lag3～lag7 d)、累积2天至累积8天(lag01～lag07 d)的PM10暴露对学生呼吸系统症状发生的危险度评估有统计学意义(P<0.05),最强效应期为污染后第4天,PM10每升高10μg/m3,学生呼吸系统症状发生增长1.4％[95％置信区间(confidence interval,CI):1.1％,1.8％].按照年级分人群分析结果显示,空气污染对幼儿园学生影响最大,其次为小学低年级(一至三年级)、中学(初高中)和小学高年级(四至六年级),PM10每升高10μg/m3,学生呼吸系统症状发生分别增长2.0％(95％CI:1.6％,2.5％)、1.5％(95％CI:0.3％,2.7％)、1.4％(95％CI:0.7％,2.1％)和0.8％(95％CI:0.2％,1.4％).结论 太原市PM10暴露对学生呼吸系统症状发生具有急性健康影响,且对中小学及幼儿园学生影响程度不同,学校应合理安排学生户外活动类型及活动时间.
与受管制的饮用水消毒副产物(DBPs)相比,含氮消毒副产物(N-DBPs)凭借其更为显著的毒性受到越来越多的研究人员的关注.环境污染及饮用水消毒工艺的改进,都可能使N-DBPs的发生增加.本文综述了卤代硝基甲烷(HNMs)、卤乙腈(HANs)和卤代乙酰胺(HAMs)这三类典型卤代N-DBPs在全球部分城市的浓度.在全球范围内,HNMs、HANs和HAMs的浓度范围分别是0.1～2.9μg/L,0.6～4.3μg/L和0.2～3.5μg/L.浓度分布表现为HANs(2.6μg/L)>HAMs(1.5μg/L)>HNMs(1.1μg/L).在中国,HANs的浓度表现出了较高的水平,平均浓度达到了3.6μg/L,明显高于美国(2.1μg/L)和欧洲等地区(1.6μg/L),这值得研究人员进一步关注.水的消毒与处理工艺对于N-DBPs的浓度具有复杂多变的影响,终端控制策略能够有效降低通过饮用水进入人体的N-DBPs浓度,进而降低N-DBPs对于人类健康的威胁.
目的 分析2019—2021南京市寒潮、热浪对人群非意外住院风险的影响.方法 收集2019年1月1日—2021年12月31日南京市4家三级医院(2家三级甲等和2家三级综合医院)每日非意外住院人数及相对应的气象和空气污染资料,采用分布滞后非线性模型(distributed lag non-linear model,DLNM)分析寒潮、热浪对居民非意外住院风险(性别、年龄、住院疾病分组)的影响.结果 本研究共收集寒季非意外住院资料137369人次,暖季141313人次.发现寒潮对非意外住院人次(性别、年龄、心血管系统疾病、呼吸系统疾病及肺炎分组)增加的风险均具有统计学意义,但性别分组、年龄分组、疾病分组组中的差异均无统计学意义;热浪仅对非意外住院中的女性人群及短暂性大脑缺血性发作和相关综合征住院人群增加的风险具有统计学意义,RR(95％CI)分别为1.207(1.043,1.396)和1.473(1.023,2.120).寒潮对人群非意外住院的滞后风险在第0天最高,累积滞后风险在0—21天中均呈上升趋势且具有统计学意义,热浪造成的滞后及累积滞后效应无明显趋势,且多无统计学意义.结论 2019—2021年南京市寒潮对人群非意外住院风险造成的影响较热浪更为显著,且存在一定的滞后和累积滞后效应,建议在寒潮期间及之后加强对人群健康的关注.
目的 定量评估南通市大气臭氧短期暴露对居民呼吸系统及循环系统疾病门诊量的影响.方法 收集整理2017—2019年南通市大气污染资料、气象资料及第一人民医院门诊病例资料.利用广义线性模型探讨臭氧水平与此医院门诊量的暴露—反应关系.结果 研究期间,臭氧日最大8小时平均(O3-8 h)质量浓度M(P25,P75)为102(80,134)μg/m3,超标天数为151 d,超标率为13.78％.南通市O3暴露与全年和冷季时呼吸系统疾病门诊量呈正相关关系,与暖季时呼吸系统疾病门诊量、循环系统疾病门诊量和儿科呼吸系统疾病门诊量呈负相关.研究期间,O3-8 h质量浓度每升高10μg/m3,呼吸系统疾病门诊量增加1.21％(95％CI:0.45％,1.97％),循环系统疾病门诊量和儿科呼吸系统疾病门诊量分别减少1.15％(95％CI:0.64％,1.65％)和1.25％(95％CI:0.62％,1.88％);冷季时臭氧暴露对呼吸系统疾病门诊量的影响增大,O3-8 h质量浓度每升高10μg/m3,呼吸系统疾病门诊量增加3.02％(95％CI:1.22％,4.85％),暖季时臭氧暴露与三种疾病门诊量均成负相关.结论 臭氧质量浓度升高与居民呼吸系统疾病门诊量呈正相关.冷季时臭氧水平升高对居民的急性健康效应影响更明显,敏感人群应及时做好防护.
目的 了解深圳市罗湖区美容美发类场所的卫生状况及可能存在的健康危害因素.方法 按照《公共场所卫生检验方法》(GB/T 18204-2013)采集罗湖辖区内226间次美容美发场所的空气及公共用品用具样品,并对其进行检测和分析;依据《公共场所卫生指标及限值要求》(GB 37488-2019)和《环境空气质量标准》(GB 3095-2012)对各项指标进行评价.结果 2016—2021年深圳市罗湖区美容美发类场所总合格率为75.86％.空气质量监测结果显示,甲醛、氨、PM2.5(室内)、PM10(室内)、PM2.5(室外)和PM10(室外)质量浓度中位数分别为0.043 mg/m3、0.065 mg/m3、44.83μg/m3、68.00μg/m3、49.00μg/m3和55.50μg/m3;室外PM10浓度低于室内(Z=-2.77,P<0.01),室内外PM10、PM2.5呈现正相关关系(rs分别为0.689和0.664,P<0.01);夏季甲醛合格率低于冬季(P<0.05).公共用品用具监测中以毛巾pH值(79.77％)、美容面盆大肠菌群(85.40％)、美容面盆菌落总数(87.23％)的合格率较低.手部真菌检出率为6.70％,手部真菌总数范围为0～70 CFU/cm2.结论 罗湖区美容美发场所卫生状况仍有一定的提升空间,公共用品用具卫生质量仍需引起重视,应开展针对性的卫生监督工作.
目的 评估2021年内蒙古自治区农村饮用水砷、镉、铬、铅和汞的健康风险.方法 对2021年内蒙古自治区农村5044份饮用水数据进行分析,采用《化学物质环境健康风险评估技术指南》推荐的健康风险评估"四步法"对砷、镉、铬、铅和汞进行风险评估.结果 2021年内蒙古自治区农村饮用水对成年人和儿童的健康风险主要暴露途径为经口摄入,儿童的风险水平均高于成人.致癌风险较高的为铬(成人:1.38×10-4,儿童:1.49×10-4)和砷(成人:1.18×10-4,儿童:1.28×10-4),超出美国环境保护局(US EPA)推荐的最大可接受风险;非致癌风险水平均小于1,非致癌风险较低.内蒙古不同地区的农村饮用水砷、镉、铬和铅的浓度和健康风险水平均为西部地区>中部地区>东部地区(P<0.05),镉和铬的浓度和健康风险水平均为枯水期>丰水期(P<0.05),砷、镉、铅的浓度和健康风险水平均为出厂水
目的 利用混合污染物统计学模型,探讨金属混合物中致机体脂质氧化损伤的主要毒性组分.方法 选取768名钢铁冶炼厂工人为研究对象.电感耦合等离子体质谱法测定尿液中钒(V)、铬(Cr)、锰(Mn)、镍(Ni)、砷(As)、锶(Sr)、镉(Cd)、铅(Pb)、硒(Se)、钴(Co)、铜(Cu)和锌(Zn)12种金属浓度;酶联免疫吸附法测定尿8-异前列腺素F2α(8-iso-PGF2α)浓度;采用MDA-硫代巴比妥酸加合物法测定尿中丙二醛(MDA)浓度.应用贝叶斯核机器回归(BKMR)、分位数g计算回归,分析尿金属与尿8-iso-PGF2α 和尿MDA水平的关联.结果 BKMR分析结果显示,当所有尿金属浓度均处于第50百分位数(P50)时,金属混合暴露的总效应使尿8-iso-PGF2α和尿MDA水平升高(P<0.05).当所有尿金属浓度处于P50与处于P25相比,尿8-iso-PGF2α水平增加36.72％、尿MDA水平增加34.24％.金属导致脂质氧化损伤的主要作用组分为Se、Cd、Zn,当其它尿金属分别固定在P25、P50、P75时,尿Se浓度每增加一个四分位间距,尿8-iso-PGF2α 水平分别增加30.7％、35.4％和41.2％;尿MDA水平分别增加35.3％、42.8％和54.7％.分位数g计算结果显示,金属混合物水平每增加25％,尿8-iso-PGF2α和尿MDA水平分别升高63.05％和61.23％.结论 金属混合暴露可能会引起机体脂质氧化损伤标志物水平升高,其中Se、Cd、Zn效应更为显著.
哮喘是儿童时期较为常见的一种慢性气道疾病.大量的流行病学研究和实验研究均表明,不仅大气污染能诱导儿童哮喘的发生,气候因素的变化也会引起儿童哮喘的发作和/或加重.大气污染物主要通过介导气道炎症、气道高反应性、氧化应激、肺功能下降等,影响哮喘的发作和/或加重.气象因素通过多种形式包括影响大气污染物或过敏原来进一步对哮喘发挥作用.本文就大气污染物及气象因素对儿童哮喘的影响与机制作一综述.
