Background:The incidence of gastric polyps in adolescents has been increasing every year in recent years. Endoscopic mucosal resection (EMR) is one of the most common treatments for adults, but there are few reports on the association between EMR of gastric polyps and the occurrence of bleeding and recurrence after the procedure in adolescents. This study sought to analyze the independent risk factors for postoperative bleeding and polyp recurrence after EMR to provide a reference for reducing the occurrence of postoperative complications.Methods:We retrospectively analyzed the data of 579 adolescent patients who developed gastric polyps from June 2016 to June 2021. Postoperative follow-up was conducted for 1 year by telephone, e-mail, and outpatient review. The general characteristics of the study population were compiled using a general information questionnaire designed by the investigators. The relationship between the patients' clinical characteristics and postoperative bleeding or recurrence was analyzed using the chi-square test. A binary logistic regression analysis was conducted to analyze the independent risk factors for the occurrence of postoperative bleeding and polyp recurrence in patients.Results:The results of the binary logistic regression analysis showed that being female [odds ratio (OR) =0.306, P=0.009], polyps >1 cm in diameter (OR =2.557, P=0.029), polyps in gastric sinus (OR =3.889, P=0.032), sessile lesions (OR =0.398, P=0.036), the need for additional intraoperative sedation (OR =3.469, P=0.005), concurrent diverticulum (OR =3.570, P=0.004), and intraoperative bleeding (OR =4.855, P=0.001) were independent risk factors for postoperative bleeding. We also found that polyps >1 cm in diameter (OR =2.134, P=0.003), multiple polyps (OR =2.117, P=0.005), adenomatous polyps (OR =2.684, P=0.041), combined Helicobacter pylori infection (OR =2.036, P=0.009), the occurrence of postoperative gastrointestinal reflux (OR =1.998, P=0.015), and an operative time ≥40 min (OR =2.021, P=0.010) were independent risk factors for the recurrence of polyps.Conclusions:There is still a high probability of postoperative bleeding and polyp recurrence after EMR in adolescents with gastric polyps. Clinicians should pay close attention to the clinical features of polyps, such as polyp size, number, morphology, and pathological type, to identify the related risk factors as early as possible and reduce the probability of postoperative bleeding and polyp recurrence in patients.
特发性血小板减少症的发病机制主要是由于体液免疫功能出现障碍而造成的,主要临床特点是骨髓巨核细胞数量增多或成熟障碍、血小板数量减少、内脏出血等.通过对免疫系统异常、淋巴细胞凋亡的作用、抗原特发性T淋巴细胞的免疫作用、Th17 细胞的CD4+T细胞分化方法、巨核细胞的异常等特发性血小板减少症的发病机制研究进展进行综述,为特发性血小板减少症的防治提供参考依据.
Objective Key targets of resveratrol(RSV)in the treatment of Alzheimer's disease(AD)are predicted by network pharmacology.Methods The traditional Chinese medicines which contain RSV were searched by the TCMSP database,and their property and flavor,meridian distribution and phamacologic action were summarized and analyzed.The targets of RSV were predicted by SwissTargetPrediction,SEA and HERB databases.The targets of AD were retrieved using GeneCards,OMIM,TTD and DisGeNRT databases.The intersection targets of RSV and AD were taken as the potential therapeutic targets.Analysis gene ontology(GO)annotations of potential therapeutic targets by biological information annotation database(DAVID).Did KEGG cluster analysis and protein interactions(PPIs)of potential therapeutic targets in STRING database,and mapped PPI networks in Cytoscape.Verified changes of AD key targets in AlzData database.Docking RSV and key proteins in SwissDock website.Results The most Tropism of taste of the traditional Chinese medicines that contain RSV:bitter,cold,in the liver.And the main phamacologic action is clearing away heat and toxic materials.There are 388 predicted targets of RSV,1624 targets of AD,119 intersection targets.Alzheimer's pathway in KEGG enriched pathway was enriched to 27 proteins.The proteins which expression changed of AD patients was analysised in AlzData database.The results of molecular docking showed that RSV had good binding ability with AKT1,IL-6,CTNNB1 and TNF.Conclusion The results of network pharmacological analysis show that the treatment of AD by RSV is multi-target and multi-pathway,which can provide reference for subsequent research directions.
Objective To explore the impact of personalized educational interventions on knowledge,attitudes,and self-management abilities of patients with atrial fibrillation.Methods Totally 70 elderly patients with atrial fibrillation admitted to the hospital from May 2022 to May 2023 were selected as the research subjects.They were divided into an observation group and a control group based on the principle of balanced and comparable baseline data such as gender and age between the groups,with 35 cases in each group.The observation group received 50 minutes of personalized self-management education,while the control group received routine care.Compare the knowledge,attitudes,and self-management behaviors towards atrial fibrillation and stroke prevention between two groups of patients.Results Before personalized education intervention,there was no statistically significant difference(P>0.05)in the scores of knowledge level,stroke risk factors,stroke symptoms,NOAC treatment,and symptom monitoring between the two groups of patients.After personalized education intervention,the scores of atrial fibrillation and stroke prevention knowledge in both groups of patients increased,and the observation group was higher than the control group,with a statistically significant difference(P<0.05).Before personalized education intervention,there was no statistically significant difference(P>0.05)in the scores of perceived severity,perceived susceptibility,perceived benefits,and perceived setbacks between the two groups of patients.After personalized education intervention,the above scores of both groups of patients increased,and the observation group was higher than the control group,with a statistically significant difference(P<0.05).Before personalized education intervention,there was no statistically significant difference(P>0.05)in self-management scores and total scores of medication,lifestyle,physical activity,and symptom monitoring between the two groups of patients.After personalized education intervention,the above scores of both groups of patients increased,and the observation group was higher than the control group,with a statistically significant difference(P<0.05).Conclusion Individualized and personalized educational interventions should be implemented for elderly patients with atrial fibrillation,which can improve their knowledge and attitudes towards atrial fibrillation and stroke prevention,and enhance their self-management level in daily life.
目的 探究针对性护理对阿替普酶早期溶栓治疗急性脑梗死患者康复效果的影响.方法 选取2021年6月-2023年6月医院就诊的124例接受阿替普酶早期溶栓治疗急性脑梗死的患者为研究对象,按照组间性别、年龄、发病至入院时间、体质指数(BMI)均衡匹配的原则分为对照组和观察组,各62例.对照组实施常规护理,观察组实施针对性护理.比较两组患者的运动功能、生活能力、神经功能恢复情况、凝血指标及并发症总发生率.结果 护理干预前,两组患者上下肢运动功能得分、日常生活活动能力量表(ADL)、神经功能缺损评分量表(NIHSS)评分比较,差异无统计学意义(P>0.05);护理干预后,两组患者上下肢运动功能得分、ADL评分均升高,两组患者NIHSS评分均降低,但观察组患者上、下肢运动功能得分、ADL、NIHSS评分均优于对照组,差异有统计学意义(P<0.05).针对性护理干预后,观察组患者部分活化凝血酶原时间(APTT)、血浆凝血酶原时间(PT)、D-二聚体(D-D)水平优于对照组,差异有统计学意义(P<0.05);观察组患者并发症总发生率低于对照组,差异有统计学意义(P<0.05).结论 将针对性护理方案应用于溶栓后的急性脑梗死患者中,可以促使患者运动功能、生活能力、神经功能的恢复,改善凝血指标,降低并发症的发生.
中心静脉导管在临床中的应用范围较广,是肿瘤科、外科等治疗中常用的输液装置,可减少穿刺次数,在一定程度上减轻对患者造成的损害,同时也便于医护人员的输液操作.堵塞是中心静脉导管输液中常见的不良情况,该情况会影响输液效用,同时增加患者感染风险.目前,临床医师已经对中心静脉导管堵塞予以高度重视,并调查了相关危险因素,制订了完善的护理措施,从而确保输液安全.
目的 分析行局部枸橼酸抗凝连续床边血液净化期间,不同滤器后游离钙浓度的应用效果.方法 以2021年1月-2022年12月医院收治的63例行连续床边血液净化患者为研究对象,根据滤器后游离钙浓度目标值及组间性别、年龄、急性生理与慢性健康(APACHE Ⅱ)评分、既往基础病史等基线资料均衡可比的原则进行分组.对照组(31 例)以 0.36～0.50mmpl/L为目标值,观察组(32 例)目标值为 0.20～0.35mmol/L,对比两组的滤器后游离钙离子浓度、凝血相关指标、滤器使用寿命以及不良反应发生情况.结果 经对应治疗后,观察组患者的滤器后游离钙浓度较对照组更低,且滤器使用寿命更长久,组间差异有统计学意义(P<0.05);两组患者的活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、血肌酐(Scr)、尿素氮(BUN)水平均较治疗前有所改善,但治疗后两组患者上述各项生化指标比较,差异无统计学意义(P>0.05).观察组患者的总不良反应发生率(6.25%)较对照组(29.03%)更低,组间差异有统计学意义(P<0.05).结论 在局部枸橼酸抗凝的连续床边血液净化期间,不同滤器后游离钙浓度均可取得满意效果,且较低滤器后游离钙浓度可延长滤器使用时间,降低不良反应风险.
目的 分析腰椎间盘突出症患者接受经皮椎间孔镜椎间盘切除术治疗的效果.方法 选取2021年1月-2022 年 12 月医院收治的 60 例腰椎间盘突出症患者作为研究对象,按照组间性别、年龄、病程、突出节段等基线资料均衡可比的原则分为两组,每组 30 例.对照组接受椎板间开窗椎间盘切除术治疗,观察组接受经皮椎间孔镜椎间盘切除术治疗,对比两组患者临床治疗效果.结果 治疗后,观察组手术优良率为100.00%,高于对照组的 80.00%,差异有统计学意义(P<0.05).观察组手术切口、术中出血量低于对照组,手术时间、住院时间少于对照组,差异有统计学意义(P<0.05).手术前,两组患者视觉模拟评分法(VAS)、Oswestry功能障碍指数(ODI)和日本骨科协会(JOA)评分比较,差异无统计学意义(P>0.05);术后 1 个月,两组患者上述指标均改善,但观察组VAS评分和ODI低于对照组,JOA评分高于对照组,差异有统计学意义(P<0.05).手术前,两组患者血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)水平比较,差异无统计学意义(P>0.05);手术后,两组患者上述指标水平均降低,但观察组GSH-Px、SOD水平高于对照组,MDA水平低于对照组,差异有统计学意义(P<0.05).手术前,两组患者白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)水平比较,差异无统计学意义(P>0.05);手术后,两组患者上述指标水平均降低,但观察组低于对照组,差异有统计学意义(P<0.05).观察组并发症发生率为 6.67%,低于对照组的 30.00%,差异有统计学意义(P<0.05).结论 经皮椎间孔镜椎间盘切除术治疗腰椎间盘突出症对患者机体创伤小,患者术后恢复快,痛苦程度轻,能减轻机体应激反应和炎性反应.
目的 探索大学生手机成瘾的潜在分类,分析大学生的手机成瘾是否存在群体异质性,探讨手机成瘾的不同潜在剖面在睡眠上的差异.方法 抽取医科大学 332 例学生样本,其中男生 159 人,女生 173 人.基于智能手机成瘾量表(陈欢)和匹兹堡睡眠质量指数(PSQI)进行潜在剖面分析,并对比手机成瘾对不同睡眠障碍的差异性影响.结果 手机成瘾是可以在一定程度上显著地正向预测睡眠.手机成瘾可分为4种潜在剖面:"非手机成瘾组""社交APP不安组""APP成瘾组"和"成瘾行为组",且手机成瘾的潜在剖面分组在睡眠和手机成瘾上的得分差异显著.进一步多重比较显示,手机成瘾的潜在剖面分组在睡眠的 6 个维度上差异显著;多因素 Logistic 回归分析显示,性别是影响手机成瘾潜在剖面分组的因素,男性手机成瘾的危险性大于女性.结论 大学生手机成瘾存在明显的群体异质性,可分为 4 种潜在剖面,在不同潜在剖面中,睡眠量表 5个维度差异显著,表明潜在剖面分组与睡眠质量有关,为干预不同类型手机成瘾大学生的睡眠质量提供可靠的依据.
目的 探究刺络拔罐疗法联合针灸治疗带状疱疹后遗神经痛的临床疗效.方法 选取 2020 年 2 月-2023 年 2 月医院收治的带状疱疹后遗神经痛患者 120 例,根据组间均衡可比的原则分为观察组和对照组,每组60例.对照组采用刺络拔罐法治疗,观察组采用刺络拔罐法联合针灸治疗,比较两组患者的视觉模拟评分法(VAS评分)、匹兹堡睡眠质量指数量表(PSQI评分)及临床疗效.结果 治疗前,两组患者的VAS评分、PSQI评分比较,差异均无统计学意义(P>0.05);治疗后,两组患者的VAS评分、PSQI评分均降低,但观察组患者均低于对照组,差异有统计学意义(P<0.05).治疗后,观察组患者的临床治疗总有效率优于对照组(88.33%vs76.67%),差异有统计学意义(P<0.05).结论 刺络拔罐联合针灸能够有效缓解带状疱疹后遗神经痛患者的疼痛,并使睡眠质量得到改善.
目的 观察分析儿童咳嗽变异性哮喘的临床特征及预后影响因素.方法 择取2019年1月-2021年12 月医院收治的 120 例咳嗽变异性哮喘患儿,分析该病患儿的临床特征及其影响预后的因素.结果 咳嗽变异性哮喘患儿多见于 3～6 岁年龄段,换季时与冬季多发;发病时间主要为睡前.主要发病诱因为呼吸道感染、气候变化.常见发病先兆包括打喷嚏、流鼻涕、鼻塞;多存在过敏史(68.33%)且喜食甜食(61.67%).单因素分析结果显示,病程、乙酰甲胆碱累积量、家族哮喘史、特应性体质、咽后壁充血、咽后壁淋巴滤泡增生、随访期间呼吸道感染等因素,预后不良组与预后良好组比较,差异有统计学意义(P<0.05).将上述 7 项指标因素纳入logistic回归分析结果显示,病程≥2个月(OR=3.732)、乙酰甲胆碱累积量＜0.5mg(OR=38.629)、家族哮喘史(OR=3.114)、特应性体质(OR=9.043)、咽后壁充血(OR=3.951)、咽后壁淋巴滤泡增生(OR=6.521)、随访期间呼吸道感染≥5 次(OR=4.179)均与患儿预后不良有关联(P<0.05).结论 病程≥2 个月、乙酰甲胆碱累积量＜0.5mg、家族哮喘史、特应性体质、咽后壁充血、咽后壁淋巴滤泡增生、随访期间呼吸道感染≥5次等7项指标均为咳嗽变异性哮喘患儿预后不良的独立危险因素.
目的 通过观察不同浓度的香烟烟雾提取物(cigarette smoking extract,CSE)对正常及肺纤维化大鼠肺成纤维细胞的影响,探讨香烟烟雾与肺纤维化的可能关系.方法 体外培养的正常及博莱霉素造模的肺纤维化大鼠的肺成纤维细胞,分别以不同浓度(25%、50%、100%)的CSE作用12h和24h.噻唑蓝还原法(MTT法)检测吸光值;流式细胞仪法观察细胞坏死与凋亡情况及细胞周期S期(DNA合成期)和G1 期(DNA合成前期)的比值.结果 高浓度(100%)的CSE主要引起两种大鼠肺成纤维细胞的坏死.较低浓度(25%、50%)的CSE对正常大鼠肺成纤维细胞无明显影响(P>0.05).较低浓度(25%、50%)的CSE作用于造模大鼠肺成纤维细胞 12h及 24h后,吸光值较对照组显著增高(P<0.05),且与时间和浓度有相关性(P<0.05).进一步检测细胞周期显示S期/G1 期的比值增高(P<0.05).结论 高浓度的CSE会引起肺成纤维细胞的坏死.一定浓度范围内的CSE对纤维化大鼠肺成纤维细胞能通过促进细胞进入S期而具有促进增殖作用,且与时间和浓度呈正相关性,而对正常大鼠肺成纤维细胞无明显影响.提示香烟烟雾可以促进肺纤维化.
目的 探究综合性护理干预对功能失调性子宫出血患者的临床护理效果.方法 选择 2022 年 1 月-2023年7月铜陵市妇幼保健院收治的功能失调性子宫出血患者70例,根据组间基础资料均衡可比原则,按照顺序编号,抽签分为两组,各35例.对照组采用常规护理干预,观察组采用综合性护理干预,比较两组护理效果.结果 采用综合性护理干预的观察组患者并发症率为 2.86%,依从性为 94.29%,分别低于对照组的 20.00%和77.14%,但组间差异无统计学意义(P>0.05).护理干预前两组患者止血时间、生活质量评分(SF-36)、睡眠质量(PSQI)评分组间进行比较,差异无统计学意义(P>0.05);护理干预后两组患者的止血时间、SF-36评分、PSQI评分均明显改善,但观察组患者止血时间短于对照组,SF-36 评分高于对照组,PSQI评分低于对照组,差异有统计学意义(P<0.05).结论 在功能失调性子宫出血患者护理中,开展综合性护理可改善患者生活质量和睡眠情况,并缩短止血时间,促进病情恢复.
目的 分析整体护理对腹腔镜下子宫肌瘤切除术患者围手术期的干预效果.方法 选择医院2021年1月-2023年3月医院诊治的56例子宫肌瘤患者作为研究对象,根据组间年龄等基线资料均衡可比的原则分为对照组(n=28)和观察组(n=28).对照组采用常规护理,观察组采用常规护理+整体护理.对比两组患者手术情况、疼痛情况、心理弹性水平及并发症发生率.结果 观察组患者手术耗时、术中出血量、首次排气时间、进食时间、住院时间均低于对照组,差异有统计学意义(P<0.05).两组患者术前视觉模拟评定量表(VAS)评分及护理前心理弹性量表(CD-RISC)评分比较,差异无统计学意义(P>0.05);术后第 1、3 天观察组患者VAS评分均低于对照组,护理后CD-RISC评分高于对照组,差异有统计学意义(P<0.05).术后观察组患者并发症发生率为3.57%,低于对照组的 17.86%,但差异无统计学意义(P>0.05).结论 整体护理干预应用于腹腔镜下子宫切除术患者围手术期中,可改善手术指标,缓解患者焦虑、抑郁等不良情绪和术后疼痛感,并有降低术后并发症发生率趋势.
Colorectal cancer has now become the most common cancer of the alimentary tract in our country,mostly caused by colorectal adenomas(CRA)gradually progressing.The onset of CRA is relatively insidious,and it has a long time period from development to progression.Early detection,early diagnosis and early excision of CRA can effectively reduce the incidence of colorectal cancer.Therefore,it is of great significance to reasonably identify and effectively predict the risk factors of colorectal adenoma patients.At present,there are relatively few studies on CRA risk prediction in China,and most of them use traditional statistical methods.More recently,the use of emerging machine learning algorithms has helped to improve results.The purpose of this review is to analyze and sort out the risk factors of CRA and summarize the research status of CRA risk prediction by domestic and foreign scholars,so as to provide reference for subsequent research.
目的 探讨集束化护理对重症肺炎新生儿的临床效果.方法 选择2022年1月1日-2023年6月30日在东南大学附属中大医院的重症肺炎新生儿 74 例为研究对象,根据组间性别、住院总病程、出生时间等基线资料均衡可比的原则,以随机数字表法分为对照组和观察组,每组 37 例.对照组采取常规护理,观察组应用集束化护理.对比两组新生儿机械通气时间、咳嗽及哮鸣音消失时间、血气分析指标、临床效果及家属护理满意度.结果 观察组新生儿机械通气时间、咳嗽与哮鸣音消失时间均短于对照组,差异有统计学意义(P<0.05).护理后,两组患儿血气分析指标中pH、血氧饱和度(SpO2)、血氧分压(PaO2)均得到不同程度改善,但观察组新生儿各项指标均优于对照组,组间差异有统计学意义(P<0.05).观察组新生儿总有效率及家属对护理满意度明显高于对照组,差异有统计学意义(P<0.05).结论 与常规护理方法相比,集束化护理可缩短重症肺炎新生儿机械通气时间及咳嗽与哮鸣音消失时间,提升临床治疗效果及家属对护理的满意度,具有临床应用价值.
Gastric mucosal intestinal metaplasia refers to the pathological process in which gastric mucosal epithelial cells are replaced by intestinal epithelial cells.89%of patients with chronic atrophic gastritis will transform into intestinal metaplasia,and 10%will transform into gastric cancer.The relative risk of developing gastric cancer in patients with intestinal metaplasia is 10-20 times higher than in healthy individuals.The aim is to use the theory of underlying qi as a guide and the principle of"pivot movement"as a basis to select suitable Chinese herbal medicines for compatibility in the treatment of chronic atrophic gastritis with gastric mucosal intestinal metaplasia.Based on this,the aim is to explore the therapeutic effect of traditional Chinese medicine on patients with gastric mucosal intestinal metaplasia.
Objective To study the current state of demand for"Internet + nursing services"for elderly people with disabilities in Shijiazhuang,which has been conducted and has not been conducted in Hebei province,to analyze the factors affecting demand,and make proposals.Methods From April to May 2023,263 elderly people with home-based disabilities were selected as the survey subjects from 16 communities in Huitong Street,Yuxi Street,Hongqi Street,and Xinshi Street,Qiaoxi District,Shijiazhuang City.By conducting a questionnaire survey,to understand the current demand for this service among elderly people who are unable to stay at home in Shijiazhuang,and analyze the factors that affect demand through single and multiple factor analysis.Results The total demand score for"Internet + Nursing Services"for disabled seniors in the city of Shijiazhuang was 94.72±14.17,and demand scores for all dimensions were at an average level,indicating the presence of demand.The results of single factor analysis show that,the difference between different genders,age,level of education,type of chronic disease,basic care,monthly household income,monthly nursing care expenses that can be accepted per month,knowledge and understanding of"Internet + nursing services",and the difference in degree of disability between disabled seniors in the Shijiazhuang home"Internet + nursing services"was statistically significant(P<0.05).The results of multiple linear regression analysis showed that gender,age,disability,and monthly acceptable nursing expenses were the factors influencing the demand for"Internet plus nursing services"for the disabled elderly at home(P<0.05).Among them,women,elderly disabled people with serious disability and high monthly acceptable nursing costs scored higher on the demand for"Internet plus nursing services".Conclusion There is a need for"Internet + nursing services"that have been carried out and have not been carried out in Hebei province for elderly people with disabilities at home in the city of Shijiazhuang,especially in health assessment and guidance and palliative care.Women,older disabled elderly with serious disability and high monthly acceptable nursing costs scored higher on the demand for"Internet plus nursing services".
Objective Based on the randomized controlled trials of Chinese medicine in the treatment of PF,to analyze the medication rules of modern Chinese medicine experts.Methods We searched CNKI,VIP,Wanfang Data.Articles were screened according to inclusion and exclusion criteria,and the prescriptions were extracted and entered.The database were established and the drug names were standardized,while the frequency characteristics were carried out according to the drug classification,taste,property and meridian tropism.Combined with the theory of Chinese medicine,cluster analysis and association rule analysis of high-frequency drugs were carried out to summarize the medication rules.Results Licorice,Astragalus membranaceus,Schisandra chinensis,Angelica sinensis and Rehmannia glutinosa were the most frequently used drugs;The most frequent drug categories were Tonic drugs,Activating Blood Circulation drugs,drugs for reducing phlegm and relieving cough and antiasthmatic,and Astringent drugs.The property was mainly warm,and the tastes was sweet,bitter and acrid..Five clusters were extracted by cluster analysis and 46 drug association rules by association rule analysis.Conclusion Clinical experts,based on the pathogenesis of PF disease of kidney-lung deficiency and phlegm-blood stasis,focus on nourishing lung and kidney,addressing both symptoms and root causes,strengthening healthy qi to elimin ate pathogens,and giving full play to the advantages of medicine in treating such incurable diseases as PF.
目的 探究无创机械通气治疗慢性阻塞性肺疾病(COPD)合并重症呼吸衰竭患者的临床效果.方法 选取 2017 年 1 月-2023 年 3 月医院收治的 88 例COPD合并重症呼吸衰竭患者为研究对象,按照组间性别、年龄均衡可比的原则分为观察组和对照组,各 44 例.对照组使用常规方式治疗,观察组在对照组治疗基础上进行无创机械通气治疗.比较两组患者的肺功能指标、炎性因子水平、生命体征指标.结果 无创机械通气治疗前,两组患者第1秒用力呼气容积、第1秒用力呼气量占用力肺活量比率、最大呼气中段平均流速、中性粒细胞绝对值、C反应蛋白水平、白细胞、降钙素原水平、血氧分压、二氧化碳分压以及心率水平比较,差异均无统计学意义(P>0.05);无创机械通气治疗后,两组患者第 1 秒用力呼气容积、第 1 秒用力呼气量占用力肺活量比率、最大呼气中段平均流速、血氧分压、二氧化碳分压以及心率水平均升高,两组患者中性粒细胞绝对值、C反应蛋白水平、白细胞、降钙素原水平均降低,但观察组患者第1秒用力呼气容积、第1秒用力呼气量占用力肺活量比率、最大呼气中段平均流速、中性粒细胞绝对值、C反应蛋白水平、白细胞、降钙素原水平、血氧分压、二氧化碳分压以及心率水平均优于对照组,各项指标组间差异均有统计学意义(P<0.05).结论 在对COPD合并重症呼吸衰竭治疗时及时开展无创呼吸通气治疗,可以改善患者血氧水平,提升肺功能,降低炎性因子水平,有助于患者恢复.
