Objective:To investigate the immunologic dysfunction and clinical significance in patients with breast cancer.Methods:To use the fluorophotometric firect measurement method and the ordinary silver staining technology to separately measures its T cell subgroup and Ag-NORs in 131 example patients with breast cancer and 37 normal control groups.Results:In patients with breast cancer and 37 normal control groups:CD3,CD4,The CD4/CD8 ratio,Ag-NORs in patients with breast cancer were significantly lower than those in the control group(P0.01);But CD20,CD8 were significantly higher than those in the cortrol group(P0.01).Conclusion:Patients with breast cancer:immunologic function is low;To examine the T cell subgroup and Ag-NORs may understand the patients with breast cancer immunologic function state.There is usable in finding out and guidance treatment.Also the content measurement of available Ag-NORs substituted the expensive T lymphocyte subgroup examination evaluates the immunologic function state of patients with breast cancer.
Objective:To evaluate MRI in the diagnosis of the knee contusion and its clinical significance.Methods:The MRI materials of 50 cases having knee contusion were retrospeectively analyzed,including the location of contusion and injuries of the adjunctive structure.Results:Of the 50 cases,61 areas of knee contusion werw found ,which includeed 17 ligament injuries,19 cases with meniscus injuries and 2 cases with occult fractures.Conclusion:MRI can accurately disapely the locateion and area of bone contusion of the knee joint as well as the adjunctive structure injuries and deduce their injury mechanism, with apparent significance for the clinical diagnosis and treatment.
Objective:To evaluate the mechanisms of tumor necrosis factor-α(TNF-α) in acute cerebral infarction.Methods:To discuss the differences of TNF-α,lipid,UA,FIB and BMI between 84 patients diagnosed with acute cerebral infarction and 80 patients of control group.Results:There were significant differences in TNF-α,TC,TG,LDL,UA and FIB (P0.01 or P0.05) between acute cerebral infarction group and control group.Conclusions:Acute cerebral infarction is the result of vaniety of factors and mechanisms,TNF-α can increase the ischemic injury through many ways.
Objective:To investigate the clinical effects of treating acute promyelocytic leukemia with bi-induction and single induction with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). Methods:Complete remission (CR) rate,early mortality and incidence of adverse reaction of ATRA+ATO group (23 cases),ATRA group (21 cases) and ATO group (20 cases) were analyzed. Results:The CR rates of ATRA+ATO group,ATRA group and ATO group were 91.4%,81.0% and 85.0%,respectively. The early mortalities were 4.3%,9.5% and 5.0%,respectively. There were no significant difference among these CR rates and early mortalities(P0.05). During treatment,patients in ATRA+ATO group had more serious hepatic dysfunction.Conclusion:Compared with ATRA or ATO single induction,ATRA+ATO bi-induction would have the same reliable clinical effect,increased CR rate,relatively short induction time and lower early mortality.
Objective:To evaluate the effect of injecting penehvclidine hydrochloirde as premedication in patients with hypertension through comparing the influence of injecting penehvclidine hydrochloirde and injecting Atropine muscularly on blood pressure(BP)and heart rate(HR)in patients with hypertension.Methods:Sixty patients with hypertension undergoing operation of abdomen were randomly divided into two group:P group was injecting 0.5mg Penhvclidine hydrochloirde intravenously while A group was injecting Atropine 0.5 mg muscularly.Record the blood pressure and heart rate of two group at the time of before injecting and 10min,20min,30min after injecting(before anesthesia induction),after endotrachea intubation.Results:The BP and HR of P group were lower than A group after injecting at any time.HR and BP changed slightly without satisfactory differences in the P group,however increased significantly in the A group.Conclusion:Penhvclidine hydrochloirde has the effect of sedation and adjust heart rate at normal limits,it can be better used for hypertension patients as premedication.
Objective:To entecavir treatment of hepatitis B associated glomerulonephritis patients liver function,kidney function.Methods:Clinical diagnosis of hepatitis B virus associated glomerulonephritis 60 cases of patients were randomly divided into control group conventional treatment of liver and entecavir treatment group. Observation of liver function,kidney function and hepatitis B virus DNA levels.Results:The compared with the control group,entecavir treatment group HBVDNA level of serum and urine protein excretion decreased significantly increased serum albumin level,and no control group(P0.05).Conclusions:Entecavir treatment of hepatitis B virus associated glomerulonephritis patients safe and effective.
Objective:To discuss the effects of ventilation support with severe acute organophosphorus pesticide poisoning(AOPP).Mehtods:The retrospective analyse and to summarize 53 in-hospital cases of AOPP saved by trachea intubation,ventilatory support choosing volume control or pressure control added to PEEP,adjusting ventilatory variable parameter by PaO2,PaCO2,PetCO2,clearing poison thoroughly,injecting atropine,sedation and nutrition supporting in our hospital.Results:3 cases died of myocardial ischemia.2 cases gave up treatment.48 cases were cured.Ventilatory support's time is 72～156 hours.average 18 hours.6～15 days in hospital,average master time in hospital is 10.5 days.no complication happened.Conclusion:The ventilatory support is effective to cure the patients with severe acute organophosphorus pesticide poisoning(AOPP)and comprehensive treatment is key.
Objective:To explore the role of the imbalance of MMP-2/TIMP-2 in fascia transversalis on the development of indirect inguinal hernias.Methods:Expression of MMP-2 and TIMP-2 in fascia transversalis from the patiens of indirect inguinal hernias and non hernias were examined with immunohistochemistry.Results:MMP-2 scores of indirect inguinal hernias were significantly higher than those of the control group (63.3% vs 36%,P0.05). No difference has been found between the TIMP-2 scores of indirect inguinal hernias and those of the control group (46.7% vs 44.0%,P0.05). However,the ratio of MMP-2/TIMP-2 was significantly higher in indirect inguinal hernias than in the control group.Conclusion:It can be expressed that the imbalance of MMP-2/TIMP-2 plays a role in the development of indirect inguinal hernia.
Objective:To explore the risk factors of diabetic early kidney injury.Method:From Jan,2004 to Dec,2008,22 diabetics who had developed early kidney injury in Nanxishang Hospital of Guilin,20 diabetics who were admitted during the same period but had not developed early kidey injury were included in the study and a retrospective analysis was carried out.Result:The risk factors mentioned below han relation to the hypoglycemia;hypertensive;triglyceride;immunoglobulin G;B2-microglobulin;cystatin.Conclusion:Hypoglycemia;hypertensiv B2-microglobulin are risk factors for diabetic early kidney injury.
Objective:To determine the effects of intrapleural injection of different dosage urokinase in patients with encapsulated tuberculous pleural effusion.Methods:81 received creating cases of tuberculosis pleurisy were divided into group A,B at randon.Regular antituberculosis treatment was given to all patients observed. Group A:45 cases,groupB 36 cases,urokinase 400 000 U/time and 100 000 U/time were injected into respectively the pleural cavity of 45 patients and 36 patients encapsulated tuberculous pleural effusion.Carry aspiration for pleural effusion three times of a week.Result:after one month treating,the group A controlling rate was 91.1%.36(80%) had remarkable result,5(11.1%) had effective result ,4(8.9% had no effective,and all had effective result 100% after 8 moths;group B;Controlling:rate was 66.6% ,3(8.3%) had remarkable result,21(58.3%) had effective result ,12 (33.3%) had no effective ,and all had effective result 83.3% after 8 months.Conclusion :There is a remarkable difference betwen different dosage urokinase rejected into the pleural cavity of patients with encapsulated tuberculous pleural effusion.
Objective:To investigate the effect of psychological intervene in the treatment of coronary heart disease.Methods:100 patients with coronary heart disease were treated with psychological intervene therapy and behaviour relaxtion training,but the controlled group only was treated with routine drug treatment.Results:There was an obvious difference between therapy and control group(P0.01).Conclusion:In the study group,the patients'quality of life and their functional status are better than the control group.The patients'length of stay is decreased significantly,and the duration of treatment is shorten.But effects are increased,so,we can draw a conclusion,effects are improved if psychological treatment and routine drug treatment are used during therapy of coronary heart disease.It is very important for the patients with coronary heart disease to accept psychological therapy frequently.
Objective:To investigate the effect of thoracic drainage and early intrapleural injection of urokinase to the prevente pleural thickening and loculated pleural effusion by tuberculosis pleural effusion.Method:sixty patients with tuberculosis pleural effusion were randomized into 2 groups,the treatment group(group 1)and the control group(group 2).The patients in group 1 were injected with urokinase 100 000 IU intrapleurally plus 50 ml of 0.9%N.S early after thoracic drainage,while the patients in group 2 were injected with 50 ml of 0.9%N.S.Results:The mean volume of fluid drained in group 1was(3 900±550)ml,while it was(3 100±500)ml in group 2(P0.01),The mean thickness of pleural in group 1was(1.10±0.15)mm,while it was(1.40±0.20)mm in group 2(P0.01),the incidence of pleural adhesion and loculation in group 1was 10%,while it was 30%(P0.01).Conclusion:Thoracic drainage and early intrapleural injection of urokinase can evidently prevent pleural thickening and adhesion.
Objective:Two kinds of cell viability assays in vitro were compared between MTT and XTT.Methods:The optical delnsity(OD),rate of inhibition and 50% inhibitory concentration(IC50)were detected by MTT or XTT assay in Daudi cell lines.Results:The coefficient of variation(CV)which detected by MTT or XTT according to OD was not significantly difference.IC50 was 14.45 μg/ml and 11.24 ug/ml respectively,the XTT assay had more sensitive than MTT(P=0.031).Conclusion:The MTT assay is cheaper;while XTT is more expensive and sensitive,its result is more stable.
Objective:To observe the adverse reaction of inflammatory arthritis patients after injected etanercept and discuss the nursing strategies.Methods:The adverse reaction durning and after injection of etanercept for patients with inflammatory arthritis was followed up survey and with early nursing interventions.Results:The adverse reaction happened 7cases included 3 cases of local redness and swelling,2cases of rashed,1 case of elevated serum transaminase and 1 case of fever,among totally 720 times of 31 cases.No case was stopped injection because of reaction.Conclusion:Early nursing interventions could descend the incidence and severtity degree of reaction etanercept,and improve the patients compliance,benefits the patients.
Objective:To analyze the effect on hematischesis,contraindication and adverse effect of combination of procaine and hypophysin used in severe hemoptysis.Methods:121 patients with severe hemoptysis were divided into A,B and C groups,in A group,procaine 300 mg was intervenous driped until hemoptysis disappear for 72 hours,in group B,hypophysin was used until bleeding stop,in C group combination of procaine and hypophysin were used,the effect on hematischesis and adverse effect was observed.Results:The effect on hematischesis in group A and group B had no signifficent difference(P0.05),contraindication and adverse effect of hypophysin was higher than procaine,the effect on hematischesis of combination of procaine and hypophysin was better than procaine or hypophysin used single.Conclusions:The effect on hematischesis of combination of procaine and hypophysin maybe better and has fewer adverse effects.
Objective:To compare the cruative effect between HyperCVAD and CHOP regimen in nasal type NK/T cell lymphoma.Methods:Clinical data of 29 patients of nasal type NK/T cell lymphoma were analyzed,then analyzed the correlation of the clinical date such as age,LDH,β2-MG,IPI,Ann-Arbor stage,number of extra-lymphatic site with the remission rate.Resuls:The Remission rate in CHOP and HperCVAD group was 50% and 61.5% respectively,the difference was no statistical significance;The level of LDH,IPI,Ann-Arbor stage and number of extra-lymphatic site were correlated with RR respectively,moreover the IPI was the independent index that affect the RR.Conclusion:The therapeutic effect of HyperCVAD regimen is as same as CHOP,and we can predict the effect by IPI index.
Objective:To investigate the effects of female central corneal thickness (CCT) in wearing soft contact lens for long term.Methods:Central corneal thickness was measured with ultrasonic(US) pachymetry. Group A,81 cases (162 eyes) was weared soft contact lens above 2 years. Group B,83 cases (164 eyes) was weared the others without contact lens.Results:The CCT in wearing soft contact lens for long term was (522.79±33.77) μm,the CCT without contact lens was (535.91±37.41) μm,respectively(P0.01).Conclusion:The female CCT is significant thiner in wearing soft lens for long term.
目的:探讨体部(全身)γ刀放射治疗系统治疗体部恶性肿瘤的可行性和疗效,总结体部(全身)γ刀的适应证.方法:方法:2005-05/2007-06随机抽取体部(全身)γ刀治疗病例216例,均有影像复查记录的病例,包括病灶346个.治疗程序:应用螺旋CT薄层扫描,获得定位图像,通过专用数据传输系统传输Dicom图像到HolyPlan 1.0 TPS(3D-treatment Planning System),依次完成体表、靶点和重要组织的自动勾画并实现三维重现;根据病变的性质、部化确定治疗参数和治疗剂量、治疗方法预显示、评估和修改,最后将获得的最佳治疗方案通过另一套专用数据传输系统,传送至体部(全身)γ刀主控电脑上,自动执行治疗计划.结果:随访3～12个月,病变病灶平均缩小67%.症状明显改善者154例,占71%;症状改善者48例,占22%;症状无改变者12例,占6%;症状加重者2例,占1%.结论:体部(全身)γ刀在治疗体部恶性肿瘤方面,有很好的效果和突出的优势.它是一种多功能、精确、安全、高效的立体定向放射治疗设备.
Objective:To study the necessity of head CT by routine repeat in patients with closed traumatic brain injury.Methods:The relation of statistics between neurosurgical medical intervention and probable predictive factors were analysed with the method of stratified and logistic regression.Result:in the group GCS≤8,statistical relation was found between medical intervention and routine repeat head CT(RRHCT),while,in the group GCS8,was not found.Conclusion:(1)RRHCT maybe benefit the patient with the score of GCS≤8.(2)if the patient with GCS8 has the ill of hypotension and/or disturbances of blood coagulation,he may be benefited from RRHCT.(3)RRHCT is not necessary for other patients else.
Objective:To know the patients' classification of diseases in prehospital emergency.Methods:From 2006 to 2008,the prehospital patients' gender,age, intreatment time,emergency diagnosis was retrospective statistical analysed in 120 emergency center in Chengde city.Results:For 3 years,prehospital patients was 19021 cases,male to female ratio was 1.41∶1;age 44.8±21.9;day during peak hours 15:00～24:00;the disease being the top 6 among them was trauma accounted,cardiovascular and cerebrovascular diseases accounted,accounting of acute poisoning,respiratory diseases accounted,digestive system diseases.Hospitalization rates of 46.73%.Conclusion:The top six diseases are prehospital main target in 120 emergency center in Chengde city.
