Despite the fact that anxiety is an undeniable wonder that is basic in human existence, it influences its exhibition and conduct. Viability in various circumstances, a normal degree of anxiety is valuable to continue to work and answerable for what they need to do, and furthermore assists individuals with driving a more economical and prosperous life. The undeniable degree of anxiety undermines individuals' psychological and actual wellbeing and contrarily affects individual, social, family, proficient and instructive accomplishment. Test anxiety and its measurements are the broadest regions of exploration lately. Examination shows that the different kinds of problems brought about by anxiety have a high recurrence around the globe. A little stress is required, yet now and then it is so confounded, execution in the test and prompts a social issue or low trust or low scholarly accomplishment. Now and then people scorn study and preparing just through appraisal and examination. Ways of life related issue incorporate lacking rest, deficient proactive tasks, terrible eating routine and bungle of time can be the contributing variables prompting test anxiety among students as announced by numerouscreators
Covid19 has irreversibly altered the practitioner way of practicing medicine. To gain a better understanding of this new infectious disease, physicians and the healthcare system must focus and adapt a new strategies for organization of inpatient care, administrative worklaods, and compensation structure. Communication, Coordination of care and access, responsiveness, and cooperation are four critical areas in which patients encounter health care system adaptation strategies. This requires special attention. Therefore what strategies to be followed for patient-oriented care and satisfaction during the covid-19 pandemic. During this pandemic, the physical boundaries created by safety equipments hinder the direct hand-on-practice and personal attention on the patient. Through the use of telemedicine, this outbreak teaches doctors and patients how to interact with one another. Weekly introductory webinars on pandemics help to smooth the interaction process by teaching how to adjust relationships, communication skills and new workplace restrictions. To ensure effective post-visit care, we need to discovercreative ways to switch between virtual and face-to-face operations. This paper aims to elaborate strategies adapted for patient-oriented care and satisfaction during the Covid-19 Pandemic
In children, fistula-in-ano is a common anorectal disorder. Infected anal glands trigger it in children, but the process is not the same as in adults. The cause in infants is repeated movement of soft stools or diarrheal episodes, which damage or traumatize the walls of the anorectal outlet, and also varies from adult anatomy. Adults do not have the same management and care protocols as children. Anything in the management and care plan for infants varies. Fistula in ano in infants and children has certain characteristics that differentiate it from adults, such as male predominance, manifestation at less than 12 months of age, multiple, but separate tracts in less than 20% of cases, rarity of complex fistulae, and low incidence of recurrence. In this case report, the efficacy of Udumber ksheer sutra (Ficus racimosa Linn) treatment and relief of fistula is well highlighted which helps in further research in this regard.
PURPOSE OF THE REVIEW The overall review is done to understand the sectors of poultry in India and their importance in upcoming years and gives an idea to enrich knowledge in the poultry sciences .The review also gives basic knowledge to the rural people all over the world to perform backyard poultry practices and to attain their own nutritious source of protein (eggs) from their backyard poultry practices and also to perform hygiene egg production practices .The review gives idea for women empowerment and ensures nutritional security for women all over world
The growing competitiveness in the global market and the success of an entire corporate plan that is closer to the efficacy of the human resources strategies is one of the main problems of organisations from the business environment. Therefore, practises and trends in human resources merge more closely with the globe. HR managers nevertheless need to be very responsive and able to effectively and empathetically adjust and convey rules. More and more experts are dedicating their attention to the study of managers' behaviour, group dynamics and direct relationships among managers and subordinates, not only with regard to their material working conditions but also in relation to the principles of management of resource resources and especially in relation to personal comportations and attitude. In this respect, this study aims at presenting a series of results after significant research has been completed, It has the general aim to examine the influence on the organisational performance of Chennai city IT sector in human resource management and performance management. The results given in this article therefore demonstrate the influence of the successful management of human resource practises on the performance of individuals and teams in the analysed organisation. The research is based on facts and information collected by the analysed firm via surveys, interviews and papers. We used quantitative methods for analysis and the conclusions of the paper, and therefore the method used to gather information on the basis of a questionnaire was to assess the view of respondents about human resources practises, the effectiveness of the management of personnel in the analysed company, and how it impacts on organisation's performance. The survey was based on the questionnaire. The statistical population analysed is shown by the IT industry staff from the city of Chennai. The study was based on a representative sample of 130 staff.
Global environmental problems have grown in recent years, notably after the industrial revolution's demise, which has resulted in increased environmental damage. Green HR initiatives help to overcome these problems. There is an increasing desire for a tactical green HR strategy that combines green management with HRM. The incorporation of Green HR initiatives into all HRM functions will undoubtedly benefit the organisation, regardless of industry. The information was gathered from 220 middle-level professionals in Chennai who worked as a Trainee, Analyst, Application developer, Associate, Product test expert, Programmer, Team leader, Software engineer, System engineer, System executive, and Technical analyst for various IT firms. The researcher utilised spss 16.0 version one - way ANOVA and cross tabs methods to explore the relationship and analyse the variation between Green HR initiatives and demographic factors of workers, as well as investigate the type and breadth of Green HRM initiatives performed by IT firms.
The purpose of this paper istopreparing special exercises according to the data of the Arion device to determine the stages of performance in completing the 110m hurdles under 20 years running, as well as identifying the effect of special training on the performance stages and completing the 110m hurdles under 20 years .The researchers used the experimental approach by designing one group with two tests, pre and post-tests, and the research sample included elite runners in the activity of 110m barriers for youth for the year 2020-2021 and with similar levels of (6) out of (8) players, and they represent (75%) of The community of origin, which was chosen in an intentional way.Among the most important conclusions reached by the researchers is the adoption of the variable determining the stages of the race in choosing exercises that affect each stage of the race in time or distance. The use of heavyweights and rubber ropes had a positive effect in codifying the training intensity of 110m hurdles runners.As for the most important recommendations, they are: conducting studies based on determining the stages of the race and adopting exercises that affect each stage as a time for the stage or as a distance for this stage, conducting a study using the ARION device on the effectiveness of 100m hurdles for women and for different groups, conducting a study using the ARION device on the effectiveness of 400m hurdles and for different groups.
Background: Ballota nigra (Lamiaceae) has been widely used as traditional medicine in many countries for the treatment of neurosedative, antidepressant, antioxidant, antibacterial, insecticidal, anticholinesterase and antifeedant effects. Aim: The present study examined the effects of Ballota nigra extract in diethylhexyl phthalate (DEHP) exposed Chang liver cells in vitro. Methods: Chang liver cells (5 x 105 cells) were exposed to 400 µM of DEHP for 24h. At the end of incubation, cells were treated with different doses of (50, 100 and 200 µg/ml) B. nigra aqueous extract and kept for 48 h and used for the assessment of insulin receptor (IR), insulin receptor substrate-2 (IRS-2) mRNA and glucose uptake and oxidation. Results: IR and IRS-2 mRNA, glucose uptake and oxidation in DEHP exposed Chang liver cells were significantly reduced (p<0.001). Cells treated with B. nigra extract could effectively enhance IR and IRS-2 mRNA and oxidation and uptake of glucose in a dose-dependent manner (p<0.001). Conclusion: The present findings are the first to report in identifying the antidiabetic activity of B.nigra against DEHP exposed detrimental changes insulin signaling molecules and glucose oxidation. Hence, B. nigra may have influence in controlling diabetes and hence it could be used a therapeutic candidate for the treatment of diabetes mellitus. Further studies on the possible role of B. nigra on the protein expression of downstream insulin signaling molecules in liver cells are warranted in order to strengthen the potential of B.nigra.
Background: Azadirachta indica or Neem of Meliaceae family is a rich source of antioxidant. Azadirachta indica is regarded as a health-promoting medicine and used in various forms globally. It is lengthily used in Indian Subcontinent province for the treatment and prevention of an assortment of ailments. Objective: The objective of this study is to observe the anxiolytic action of methanol extract of Azadirachta indica. Materials and methods: Methanolic extract of Azadirachta indica (MEAI) was administered in the doses of 100, 300 and 600 mg/kg p.o. For determination of anxiolytic activity, hole board (HB), open field (OF), elevated plus maze (EPM) and light/dark exploration (LDE) tests were used. Results: The period and quantity of the poking of the head in HB test was amplified by the methanolic extract of Azadirachta indica in a substantial manner. The total exhausted duration was augmented by the extract in EPM. The extract created a remarkable boost in the total exhausted timing in LDE test. Also, it augmented the number of crossings and lessend the total period of the indolence in light box. The extract displayed significant boost in the the total number of rearing and assisted rearing in OFT. Conclusion: This work exhibits EAAI anxiolytic action which might be credited to its ‘phyto-constituents’ viz. ‘alkaloid’, ‘steroid’ and ‘triterpenes’. This is possibly a moderately reasonable therapeutic agent for the cure of anxiety dysfunction, since Azadirachta indica is ubiquitous and abundantly grown.
It is known that periwinkle is a very beautiful flowering ornamental plant, which grows a lot in home gardens. But few people know that this is also a very beneficial medicine for health. Since ancient times, many people have known to take advantage of the effects of Catharanthus Roseus to get good results in the treatment of diseases. Catharanthus roseus is an herbaceous perennial plant originating from Madagascar, then introduced to many countries around the world, including Vietnam. Initially, periwinkle was only grown for ornamental purposes because the tree was healthy and gave beautiful flowers all year round. However, later scientists discovered many of its healing effects, especially the effect on cancer. This article analyzes some of the scientific components of Catharanthus Roseus as well as its amazing effects in the treatment of several diseases.
Diabetic nephropathy (DN) is extremely severe and most general complication of diabetes which could be foremost reason of unceasing kidney failure. Aim: The aim of the present study was evaluated the reno-protective effect of lupeol in high fat diet and sucrose-fed diabetic nephropathy in Wistar rats. Methods: Lupeol was administered to the diabetic rats at a dose of (25 mg/kg body weight) was given once a day until the end of the study (60 days post induction of diabetes) to high fat diet-induced diabetic rats. Real Time-PCR analysis was performed in order to study reno-inflammatory signaling (IL-6, IL-1β and TNF-α). Results: Lupeol treatment significantly reduced hyperglycemia and significantly lowered oxidative stress markers in the renal tissue of treated diabetic groups. Moreover, lupeol treated animals exerted decrease in mRNA levels and low serum concentrations of IL-6, IL-1β and TNF-α compared to diabetic control rats. It showed a significant decrease in NF-kB activation in the diabetic kidney. Conclusion: Lupeol treatment mitigates oxidative stress and suppresses renal inflammation via inhibition of NF-kB in diabetic kidney in early progressive diabetic nephropathy. Therefore, the triterpenoid could be an effect treatment option in early progression of diabetic nephropathy in clinical trial.
HIF-1α (hypoxia inducible factor 1 alpha) is a protein that controls cell growth and differentiation and has been linked to cancer in humans. In cancer cells, HIF-1 triggers the carcinogenesis cascade function. The HIF-1 receptor is thought to be the initiator of signaling and its `over expression has been linked to a variety of human cancers, including breast cancer, lung cancer, and colon cancer. As a result, HIF-1 becomes a possible therapeutic target in the development of HIF-1 inhibitors. The aim of this study is to look into natural potential inhibitors. To accomplish this, the chemical structures of all substances were downloaded from the PubChem database. PyRx was used to conduct the docking and Pymol was used to evaluate the resulting binding modes. Berberine, a natural compound demonstrated the strongest binding modes as compared to other inhibitors, with the lowest binding energies (-8.6 kcal/mol). This study indicates that Berberine interacts favorably with the necessary amino acid residues at HIF-1's catalytic site. Present findings of the molecular docking analysis may be useful as a compound model for further in vitro and in vivo research.
In recent years, there has been a greater focus on the possible toxicity of several herbal medicines. Many different forms of poly herbal formulations are utilized in ancient systems of medicine such as Ayurveda, Siddha, and Homoeopathy. Many herbal formulations have been shown in animal models and clinical trials to be an effective agent for treating coronary heart disease, peptic ulcers, and skin problems etc., however, nothing is known regarding PHF's potential chronic toxicity. The purpose of this study was to explore at the safety of poly herbal formulation (PHF) in laboratory rats. Wistar rats were separated into four groups of 50 rats each for chronic toxicity (20 males and 20 female). The experimental animals were administered PHF at doses of 250,500, and 1000mg/kg for 180 days, satellite group animals also treated with 1000 mg/kg. while the control animals were given distilled water. The animal's body weight, food and water intake were all tracked on a weekly basis. In addition, at certain observation time points, their biochemical and haematological parameters, histology, and body and organ weights were also measured. PHF did not induce noticeable anomalies in physiological parameters or pathological changes in the major organs of rats, according to the results of the chronic toxicity study. The results showed that PHF at the specified levels had no adverse effects on the animals. As a result, it is acceptable to conclude that PHF is safe at the dosage levels studied and does not produce chronic toxicity in animal models.
The present study synthesized synthesis and Characterazation with studing Antioxidant activity of Chalcone derivatives. Chalcone [C1] was prepared from reaction of Terephthaldehyde and p-hydroxy acetopheneone. then Chalcone treated with drug contain primary amino group (metoclopramide hydrochloride) to produse schiffe base [C2], At last [C2] reactive with different type of material to configure new derivatives [C3-C8] includes (Tetrazole, Thiazole idenones, Beta-lactam, and Oxazepine).Compounde were characterized by different physico-chemical techniques like, Melting Point, FTIR, 1HNMR. some of these compound have bene screened for their antioxidant activity.
In the case presented, classic signs and symptoms of chest pain (that could be associated with MI) are evident. For instance, H.G. experiences chest pain radiating to the left arm and his jaw. In addition, the patient experiences diaphoresis and shortness of breath. With the perceived lack of oxygen supply to the myocardial cells, this outcome could be attributable for the chest pain. When the intima of the artery is exposed to an accumulation of the lipids, the latter evolves to yield fibrous-fatty lesions. Indeed, these lesions may contain fibrous caps. When ruptured, the caps are likely to allow the lipid center into the patient’s bloodstream. The eventuality is that the formation of clots is stimulated, translating into the process of thrombogenesis. When a patient undergoes the latter, vessels are blocked. In turn, oxygenated blood is blocked from passing and myocardial cells are deprived of nutrients.
Oral health is important for the overall wellbeing of an individual. It is an important element of general health throughout life(1). It is a basic human right attributed to people to having essential oral health care, therefore ensuring health and quality of life(2).The most routinely caused diseases of the dental cavity are dental caries ,periodontal problems and malocclusions in children. Unfortunately, oral care remains more focused on treatment than on prevention. Oral health is an essential component of health throughout life, due to the association of oral cavity with the development of a healthy personality, perceptions, and the overall experiences of pleasure.(3) However, millions of individuals suffer from dental caries and periodontal disease, resulting in unnecessary pain, difficulties in chewing, swallowing and speaking and sometimes unaffordable high medical costs. Untreated oral diseases among children frequently lead to serious general health problems, significant pain, interference with eating and school absence.(4) Thus the aim of the study is to evaluate oral health status of 6 year old school going children in Chennai.
(DEHP) exposed Chang liver cells in vitro. Methods: Chang liver cells (5x105 cells) were exposed to 400µM of DEHP for 24h. At the end of incubation, cells were treated with different doses of (50, 100 and 200 µg/ml) cuminaldehyde for 48 h. After 48h, the cells were used for the assessment of insulin signalling molecules (IR, IRS-2, and Akt) and glucose oxidation in Chang liver cells. Results: IR, IRS-2 and Akt mRNA and glucose oxidation in DEHP-exposed Chang liver cells were significantly reduced (p<0.05). Treatment with cuminaldehyde enhanced IR, IRS-2 and Akt mRNA and oxidation of glucose significantly (p<0.05). Conclusion: The present findings are the first to report to identify the antidiabetic role of cuminaldehyde against DEHP exposed detrimental changes insulin signalling molecules and glucose oxidation in liver cells. Hence, cuminaldehyde may have significant role in controlling diabetes and hence it could be used a therapeutic natural drug for the treatment of diabetes mellitus.
Calcaneum is the largest tarsal bone which forms the prominence of heel. A plantar calcaneal spur is an outgrowth of the calcaneus. Chronic inflammation at the insertion of tendons or plantar fascia is a common cause of spurs. Few studies showed a correlation between plantar fasciitisandcalcaneal spurs. Present study also explains that correlation is profound in subjects with risk factor such as advanced age, weight and developed Osteoarthritis. About 40 patients of known age and sex with history of heel pain were studied. Inform consent had taken prior to study. All 50 patients had completed X-ray lateral view of affected foot. Radiological study shows that about 30 patients were having calcaneal spur. Thus this study helps in not only understand the correlation of plantar fasciitis with calcaneal spur but it also helps the surgeon or orthopaedician to draft a line of treatment depending on the severity of symptoms that is conservative or surgical intervention. CONCLUSION: About 80% of patient of Painful heel having plantar fasciitis with PCS and is associated with high proportion in elderly, overweight, female patients. It is known that majority are found deep to plantar fascia, surrounded by fibrocartilage. Histologically PCS has a trabecullar pattern and is in association with the factor listed above that determines the heel pressure. Potential causes of tendencies at heel, includes tear in plantar fascia, fracture of calcaneum or fat pad atrophy or any other neural cause appear prominently in of PCS.
Informed consent for clinical treatment has become a vital part of contemporary medical practice; it means different things in different contexts, is variably practiced and rarely achieves the theoretical ideal. Informed consent has become the primary paradigm for protecting the legal rights of patients and guiding the ethical practice of medicine. It may be used for different purposes in different contexts: legal, ethical or administrative. Study title: “Knowledge and opinion regarding written consent in hospital practice among patients and family members.” Materials and Methods: The study adopted Non-Experimental Descriptive design carried out among 200 subjects (100 patients and 100 family members). Non-probability purposive sampling technique was used and was statically analysed after collecting the data through A structured questionnaire for assessing the knowledge and opinion regarding written consent. Ethical clearance was taken from the Institutional ethics committee. Data analysis was done using descriptive statistics. Results: The study results showed that majority 61% of patients have average knowledge, 23% samples have good knowledge and 16% samples have poor knowledge with the mean of 9.36 and SD of 3.39. The majority of samples 66% in group of family members have average knowledge, 25% samples have good knowledge and 11% samples have poor knowledge with the mean of 9.95 and SD of 3.20. Conclusion: The findings of the study showed demographic variables like age and marital status of the patients are associated with the knowledge regarding written consent while only marital status of the family members is associated with the knowledge regarding written consent. Opinion wise distribution shows that family members and patients are having similar opinion regarding written consent in hospital practice. Recommendation: It is suggested that a similar study can be indicated with a larger population.
Endothelial cells are the dynamic structures that are essential for the maintenance of constant blood flow in the vasculature. The functions of vascular endothelial cells are vasomotion, blood coagulation, and inflammation. Numerous mechanoreceptors are present on the surface of the endothelium. Mechanotransduction occurs across the endothelial cells as a result of the shear stress stimulation which will alter the structural, functional, and genetical modification of the endothelial cells. Blockage of blood flow is the root cause for most of cardiovascular diseases. Poor physical activity and unhealthy lifestyle habits favoring the deposition of fats plague formation in the vessel walls. Endothelial dysfunction is a condition where endothelial cells are not able to release the substance which maintains vascular tone. This is an overall review that summarizes the endothelial cells' pathophysiological aspects along with the methods to detect endothelial dysfunction.
