Primary intraosseous squamous cell carcinoma (PIOSCC) of the mandible is a rare malignancy, and evidence regarding optimal management remains limited. This retrospective study aimed to evaluate clinical outcomes, explore potential clinicopathological associations, and assess the diagnostic performance of imaging modalities in patients with solid-type PIOSCC treated at a single centre. Fifteen consecutive patients with solid-type PIOSCC of the mandible were retrospectively reviewed. Clinical variables, including peri-mandibular muscle infiltration and surgical margin status, imaging findings from computed tomography (CT), magnetic resonance (MR) imaging, and fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT), treatment modalities, and survival outcomes were analysed. Overall and disease-specific survival were evaluated using Kaplan–Meier analysis. The 5-year disease-specific survival rate was 72.2
To evaluate the effect of magnetic resonance imaging (MRI) slice thickness and voxel geometry on digital dental implant planning compared to cone-beam computed tomography (CBCT). Edentulous phantoms were scanned using CBCT and two MRI protocols: anisotropic and isotropic. Two calibrated examiners digitally planned the position of four implants for each sample (n = 8) per exam (CBCT, anisotropic and isotropic). Diagnostic accuracy was assessed using implant angular deviation and linear measurements. Image quality was evaluated using a questionnaire regarding visualization of anatomical structures. Cost-to-planning-time ratio was assessed by exam costs per minute of planning. The Friedman and Wilcoxon tests were used to evaluate differences in diagnostic accuracy, planning time, and cost-to-planning-time ratio. Image quality ratings on a 5-point scale were classified as non-valid (≤ 2) or valid (≥ 3) for clinical use. Reliability was assessed by percentage agreement, and differences were evaluated using the chi-square test. A total of 96 implants were planned, with 32 in each exam. No significant differences were observed between exams for angular deviation (p > 0.197), linear measurements (p > 0.305), image quality (p > 0.132), or planning time (p = 0.093). However, CBCT had lower cost-to-planning-time ratio than anisotropic and isotropic MRI (p = 0.012), which did not differ from each other (p = 1.000). Inter-examiner agreement on image quality for anisotropic and isotropic MRI varied widely, with lower ratings for the mandibular nerve canal. No statistically significant differences were detected among the imaging protocols in diagnostic accuracy or image quality under the investigated in vitro conditions.
Numerous preclinical studies have investigated bioactive coatings on titanium implant surfaces to enhance antibacterial and osteointegrative performance in oromaxillofacial applications. However, these studies employ heterogeneous experimental methods and biological outcomes, making it difficult to identify which coating strategies hold the greatest translational potential. This systematic review and Bayesian network meta-analysis (NMA) aimed to rank titanium coating strategies published over the last five years according to their biological performance, using a quantitative statistical framework. Nine coating categories of increasing compositional complexity, ranging from single-component (inorganic, organic, peptides/growth factors) to two-component and three-component formulations combining these classes with each other or with antibiotics, were compared across six biological outcomes in preclinical models. Inclusion criteria followed the PICOS framework for studies published between 2020 and 2025. Three databases were searched according to PRISMA 2020 and its NMA extension. Mean difference (MD) was used for outcomes on a common scale; ratio of means (RoM) when measurement units were heterogeneous. Treatment ranking was estimated using the surface under the cumulative ranking curve (SUCRA). Study reporting quality and data completeness were assessed, and studies with insufficient quantitative data were excluded from the quantitative synthesis. Of 143 records identified, 59 met the inclusion criteria and 40 contributed to the quantitative synthesis. SUCRA rankings indicated that three-component hybrid coatings incorporating antibiotics achieved the highest antibacterial performance and osseointegration, while inorganic coatings functionalized with peptides or growth factors demonstrated superior osteogenic differentiation. Organic coatings combined with peptides or growth factors showed the greatest cell proliferation. These findings provide the first evidence-based ranking of bioactive coating strategies for titanium implant surfaces, suggesting a potential advantage of multi-component formulations over single-agent approaches across biological outcomes. The identified compositional complexity gradient may inform the rational design of future multifunctional coatings and help prioritize candidates for further preclinical and translational validation in oromaxillofacial applications.
To describe same-day discharge and recorded postoperative complications after bimaxillary osteotomy in a selected retrospective cohort, without establishing comparative safety. The cohort comprised 80 adults classified as American Society of Anesthesiologists (ASA) I–II who underwent bimaxillary osteotomy, with or without adjunctive procedures, at a day-surgery center in Riyadh between January 2022 and November 2023. Forty were discharged on the same day and 40 were admitted overnight. Discharge planning reflected patient preference and clinical assessment. The primary endpoint was the recorded postoperative-complication indicator in the available clinical dataset. Post Anesthetic Discharge Scoring System (PADSS) readiness was described separately. Complication proportions were compared without adjustment for confounding. PADSS scores ≥ 9 were recorded in 40/40 same-day and 32/40 overnight patients. Recorded complications affected 2/40 (5.0
Oral cancer remains one of the most common malignancies worldwide and is associated with significant morbidity and mortality. Conventional therapies often cause systemic adverse effects and reduced patient compliance. Mucoadhesive buccal drug delivery systems provide localized and sustained drug release, potentially enhancing therapeutic efficacy while minimizing systemic toxicity. This study aimed to develop and optimize a mucoadhesive buccal gel containing Curcumin, Quercetin, and Resveratrol for localized oral cancer therapy using a 32 full factorial design. Nine mucoadhesive buccal gel formulations (F1-F9) were prepared by the dispersion method using Hydroxypropyl Methylcellulose K15M (HPMC K15M Grade) and Carbopol 934P as mucoadhesive polymers. The formulations were evaluated for appearance, pH, viscosity, spreadability, drug content, mucoadhesive strength, and in-vitro drug release. Drug-excipient compatibility was assessed using Fourier Transform Infrared spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). Drug release kinetics were analyzed using Zero order, First order, Higuchi, Hixson-Crowell, and Korsmeyer-Peppas models. Statistical optimization was performed using Design-Expert® software. All formulations exhibited acceptable physicochemical characteristics, including suitable pH, homogeneity and formulation-dependent differences in viscosity, spreadability and mucoadhesive strength. The optimized formulation F5 demonstrated acceptable stability under accelerated conditions for 6 months. Increasing polymer concentration enhanced viscosity and mucoadhesive strength while reducing spreadability and drug release. The cumulative drug release after 8 h ranged from 71.50
