Background: Sensorineural hearing loss (SNHL) is a type of hearing impairment typically associated with aging, where the pathology lies in the inner ear or the vestibulocochlear nerve. It might be congenital or acquired. Pediatric SNHL is comparatively rare, and even more so when linked to allergic etiologies. Hearing loss is associated with Badhriya (~deafness) in Ayurveda and one among the Karnaroga. Clinical findings: This case describes 15year old girl presented with symptoms such as partial hearing loss, tinnitus and ear pain over a period of 5 months. The underlying etiology was associated with Allergic Rhinitis, a rare but clinically significant contributor to SNHL in children. She was diagnosed with SNHL in March, 2025. Interventions: Ayurvedic treatment commenced with procedures viz Nasya (~nasal therapy), Karnapoorana (~auricular oil therapy), Matrabasti (~oil enema) are given for 23 days and Ayurvedic medicaments viz Pathyadi Kvatha, Triphala Guggulu and Sudarshan Ghanvati for 23 days and follow up medicaments for 28 days. Outcome: Pure tone Audiometry (PTA) showed significant improvement in hearing threshold. The right ear improved from a mean of 33 dB (mild hearing loss) to 17.5 (Normal sensitivity) dB indicating approximately 46.9% improvement. The left ear improved from a mean of 80 dB (severe hearing loss) to 22.5 dB (mild hearing loss), showing approximately 71.8 % improvement. Symptomatic relief was evident, with tinnitus reduced from 6 to 2 and ear pain score reduced from 7 to 3 on the Visual Analogue Scale (VAS). Conclusion: This case highlights rare association of pediatric SNHL with allergic rhinitis and demonstrates that individualized Ayurvedic management, including therapeutic procedures and medications leads to clinical and audiometric improvement. Improvements were supported by clinical findings and PTA reports with sustained benefits and no adverse effects observed during treatment and follow up.
Background: Fever is a frequent pediatric presentation and, though physiologically protective, may cause adverse outcomes if inadequately treated. Conventional antipyretics are limited by tolerability and challenges in oral administration in young children. Ayurveda describes fever as Jwara, arising from impaired Agni (digestive fire), Ama (metabolic toxin) accumulation, and Dosha (humor) imbalance, for which Tikta-rasa (bitter taste) predominant formulations are indicated in early stages. Panchatikta Kashaya, described in Chakradatta Jwara Cikitsa, possesses antipyretic potential but has poor palatability. Rectal delivery, as Gudavarti (rectal suppository), offers improved absorption and compliance. This double-blind randomized controlled trial evaluates the antipyretic efficacy of Panchatikta Kashaya Gudavarti in children aged 1-5 years with mild to moderate fever, compared with Amrutottaram Kashaya Gudavarti. Objective: To compare and assess the antipyretic efficacy of a single administration of Panchatikta Kashaya Gudavarti with Amrutottaram Kashaya Gudavarti (rectal suppositories) in children aged 1-5 years. Methods: The ongoing study is a prospective, double-blind, randomized controlled, superiority, single-center, efficacy trial of a total 50 participants diagnosed with Jwara (Fever). The trial group will receive single administration of Panchatikta Kashaya Gudavarti, rectal suppository of 2 grams, and the antipyretic effect will be assessed 15 minutes, 30 minutes, 1 hour, 2 hours, and 3 hours post-administration based on the reduction in temperature. Control group participants will similarly receive Amrutottaram Kashaya Gudavarti of 2 grams, and will be assessed for reduction in temperature in the same way. The primary outcome is the reduction in temperature and other features of fever on GRASP fever chart and graded clinical parameters of Jwara. The secondary outcome measure is to note the comparative efficacy of Panchatikta Kashaya Gudavarti with Amrutottaram Kashaya Gudavarti. Conclusion: The study is expected to demonstrate the safety and efficacy of the Ayurvedic intervention Panchatikta Kashaya Gudavarti (rectal suppository) in reducing mild to moderate fever.
Background: Palmoplantar psoriasis is a chronic, non-contagious, inflammatory skin disorder that primarily affects the palms and soles. Despite advances in biologic therapies, its management remains challenging. The condition leads to considerable discomfort and disability, limiting a patient’s ability to perform daily tasks and occupational duties. Owing to its complex, multifactorial etiology, effective management usually requires a comprehensive, multimodal treatment strategy. In Ayurveda, its clinical presentation closely resembles Vipadika, a condition marked by Paani-Paada Sphutana (cracking of the palms and soles) accompanied by Teevra Vedana (severe pain). Findings: A 6-year-old boy presented with a 1-year history of patchy, dry, scaly, itchy, and bleeding lesions on bilateral palms and soles, diagnosed as Palmoplantar Psoriasis, and was successfully managed with Ayurveda. Intervention: Shamana Chikitsa (Pacification therapy) according to the Avastha (clinical presentation) of the patient for 11 months, followed by Shodhana (Bio purification), that is Vamana (Therapeutic emesis). Results: The patient reported significant improvement in complaints and Palmoplantar Psoriasis Global Assessment (PPPGA) score reduction from 4 to 1 after Shodhana (Bio-purification). The Dermatology Life Quality Index (DLQI) score improved from 25 to 2. Conclusion: Shamana (Pacification), along with Shodhana (Bio-purification), proved to give more efficient results in terms of reduced interventional duration, rather than Shamana alone in this case. Treatment was well tolerated, and no adverse drug reaction was reported during the entire course. Ayurveda showed great results in clearing the lesions without any complications and without the use of topical or systemic steroids during the whole course of treatment.
Background: Chamomile, derived from both Matricaria chamomilla and Chamaemelum nobile (L.) All, has long been used as a holistic treatment and has demonstrated the ability to address health issues associated with women's health, including menstrual cramps, anxiety, stress, and sleep problems. Chamomile has three major active compounds – apigenin, alpha bisabolol and chamazulene – which provide anti-inflammatory, analgesic, antispasmodic and mild sedative properties. Chamomile has an apple-like fragrance, which promotes relaxation through aromatherapy. Objectives: The purpose is to review the effectiveness of chamomile in relieving the symptoms of dysmenorrhea, anxiety, and sleep disturbances in women (e.g., premenstrual syndrome, menopause, postpartum) relative to peppermint and lavender. Methods: The review is based on a review of a comparative analysis of the above-mentioned herbs. This narrative review explains and critically evaluates reported experimental and clinical studies on the role of chamomile in women’s health. Results: Reported studies support the effectiveness of chamomile in reducing menstrual pain, promoting calming through aroma, and reducing anxiety while improving the quality of life associated with multiple women's health conditions. In addition, it has unique categories of benefits. Conclusion: Despite the challenges of small sample sizes, varied dosages and inconsistent preparation techniques, chamomile demonstrates strong potential as a gentle, sensory alternative therapy. Future studies should emphasize the need for standardized studies with larger samples, longer follow-up and optimized aromatherapy techniques to assess the long-term safety of chamomile
Background: Siddhasara Samhita and its Siddhasara Nighantu are important text of Indian Medical Science belonging to early medieval period. These were written after the prime three texts - Brihat trayi and before the lesser three texts - Laghu trayi, thus making them important to be referred. Written by Acharya Ravigupta in easy language aim for mediocre this have been a physician guide book. With regard to Nighantu, Siddhasara Nighantu is a pioneer work in Medieval period after Vedic period Nighantus, it has given synonyms of important plants-metal-minerals within less than hundred verses. Objective: To study and analyse importance of Siddhasara Nighantu. Method: Applicable materials are taken from the published texts and available translation by different authors on Siddhasara Samhita and Nighantu - lexicon. Through literature review, the objective of this study is to analyse and highlight the importance and utility of Siddhasara Nighantu. Result: Many interesting findings were found and are discussed. From intellectual historical significance to easy reference, this linguistic archive, an early pharmacopoeia and handy work on many names of important drugs is important As quoted and explored, this is for easy identification of drugs and quick guidance to physician. Conclusion: This work as an essential text to a physician, should be explored to larger extent; as true to Siddhasara Nighantu another name, its Sarottam, best of all. Further studies to see the order and its contribution to other Nighantus, would be helpful to scholars of Dravyaguna and all.
Background: Eosinophilic Esophagitis (EoE) is a chronic immune-mediated esophageal disorder, often resistant to available standard therapies such as corticosteroids. A condition where a type of white blood cell (eosinophil) builds up in the esophagus, causing inflammation, tissue damage, and dysfunction. It causes chronic swallowing difficulties, food impaction, and pain, often requiring dietary changes, medication, or endoscopic dilation to manage. Clinical Findings: A 23year old male patient visited to hospital presented with complaints of dysphagia, epigastric burning vomiting sensation and burping continued since last four years. Intervention: Under Ayurvedic assessment, this case was taken under spectrum of Amashayagatavata, and a combined protocol of Panchakarma therapy and internal medication was administered. The patient underwent an 8-day yogabasti regimen comprising Niruhabasti with Yashtimadhu Ksheerpaka and a polyherbal kalka including Guduchi, Manjishtha, and Shatapushpa, and Matra basti with Dadimadi Ghrita. Oral medicines included Dhanwantaram Vati, Kamdudha with Mukta, Anuloma DS, and Vomitab syrup. Outcome: USG after two months was normal; endoscopy revealed resolution of eosinophilic inflammation and sliding hiatus hernia. Eosinophil count dropped from 986 cells/cmm to 330 cells/cmm. Symptom resolution was documented via Patient Relief Scale, endoscopic reassessment, and a Quality of Life (QOL) scale. Conclusion: The case illustrates a promising comprehensive approach with yoga niruha basti pattern along shaman yogas for chronic Eosinophilic esophagitis with a seven days IPD and four months follow ups period without any adverse effect reported during treatment with Ayurveda showed patient improvement warranting larger controlled studies.
Background: Acharya Charak has explained three treatment modalities, in which Lepa is one of the widely used models of Bahir-parimarjan (treatment modalities used externally). As other treatises Yogaratnakara is widely popular amongst ayurveda practitioners as a handbook for ayurveda treatments for various diseases. Objectives: To study conceptual foundation of Lepa Kalpana and to analyse data of compiled formulations of Lepa from Yogaratnakara. Material and methods: For conceptual study of Lepa chikitsa comprehensive review of Charak Samhita, Sushrut Samhita, Ashtang Hriday, Sharangdhar Samhita, Bhavaprakash Samhita and Yogaratnakara was done. Formulations of Lepa mentioned in various diseases in Yogaratnakara was compiled, analysed and reported in summarized view. Result: In Yogaratnakara 511 Lepa formulations are described for various diseases and conditions. Benefits of Mukhalepa are emphasized. Contraindications of Lepa chikitsa also explained. Generally, Lepa is a derivative of Kalk Kalpana, but in Yogaratnakara, various formulations of Bhaishajya Kalpana are described for the application of Lepa, like herbal juices, carbonised black coloured ash of herbs, decoction, oils, biomedical fermentations, etc. With Herbal ingredients major mineral, and animal sources are utilized for the formation of Lepa. Lepa chikitsa advised in various conditions of almost 61 diseases. On the basis of study, functions of Lepa are classified into 31 types. Lepa Chikitsa mainly has its local effect, but in some conditions, it shows a systemic effect. Conclusion: Lepa Chikitsa might not be a perfect first line of treatment in all diseases or conditions, but it will provide greater help as a supportive treatment.
Background: Chloroxylon swietenia DC (CS) or Bherra (East Indian Satinwood) is a traditional medicinal plant used in the south-eastern part of India. Different parts of this medium -sized deciduous tree, such as leaves, bark and fruits, have been used in folklore medicine to treat pain and inflammatory diseases. In spite of its many ethnomedicinal applications, strong scientific evidences still limited. Objective: The purpose of this review is to evaluate the anti-inflammatory activity of CS extracts, along with the phytoconstituents involved in this activity. Materials and Methods: The relevant information was gathered from classical Ayurvedic texts such as Dravyaguna vijnana by P. V. Sharma and standard reference books like Indian Medicinal Plant and Wealth of India. Also, the electronic databases, including PubMed, Science Direct, Google Scholar and IMPPAT 2.0, were searched to compile scientific work related to phytochemical and pharmacological activities. Results: Phytochemical studies indicate that CS extracts contain a wide range of bioactive compounds, which may be responsible for a dose-dependent anti-inflammatory effect in various experimental models. Discussion: The anti-inflammatory effect of CS is due to the presence of bioactive components in CS extracts, which can be responsible for modulating key inflammatory pathways, including arachidonic acid through inhibition of lipoxygenase, cyclooxygenase and phospholipase enzymes. Also, it shows a good safety profile with no toxic effects at experimental doses. Conclusion: Experimental and phytochemical profiles support the traditional claim and scientific validation of anti -inflammatory potential of CS. However, further research on isolation, standardization and multicentric clinical trials is essential to establish a potent anti-inflammatory drug.
Background- Manuscripts literally means “Written by hand” which carried the personal touch and clinical understanding of scholars from past centuries. These Manuscript contain centuries of verifiable observations, unique therapeutic formulations, and surgical importance that remain largely unpublished. Despite their Standard and clinical significance, a vast majority of Ayurvedic manuscripts remain unedited and inaccessible to the modern scientific community. Due to environmental degradation, physical negligence and the lack of systematic digitization, this primary source of traditional medicine is at risk of permanent loss, creating a critical gap in our medical system. Gutikayogachintamani is untouched Manuscript present in Oriental Institute of Baroda. This is a truly unique manuscript. After searching other several manuscript centers, we discovered that this is the only surviving copy of the work in existence. The Gutikayogachintamani might have been a specialized manual used by a specific group of Vaidya in a particular region. It is a single folded sheet with 2 folios. Aim & objectives: To Systematically study and translate the manuscript ‘’Gutikayogachintamani’’ and evaluate its therapeutic significance in the context of classical Ayurvedic literature. Methodology- Unpublished and complete Manuscript Gutikayogachintamani is collected from oriental institute of Baroda. Observation: In this Manuscript Two kalpas are given out of which first one is Gutikayogachintamani and other one is Hemagarbhapottaliras. In these Dravya of Formulation with Matra, Preparation method, Indications, Benefits and Aushadhsevankala have been mentioned in detail. Conclusion- This Manuscript includes Gutikayogachintamani, Dravya of Formulation with Matra, Preparation method, Indications and benefits. It is a collection of Two Kalpas. Formulations like Gutikayogachintamani and other should be further studied and clinically explored to see its efficacy. This manuscript represents an invaluable repository of traditional medical knowledge that warrants rigorous scholarly exploration to inform future clinical research and therapeutic practice.
Background:Digestive disorders such as Vataja Udarashoola (abdominal colic) are commonly encountered in pediatric clinical practice. In Ayurveda, these conditions are attributed to Agnimandya, Ama accumulation and vitiation of Vata–Kapha Dosha, resulting in impaired digestion and abdominal discomfort. Classical Ayurvedic formulations such as Ajamoda Arka and Yavakshara are indicated in the management of the above conditions owing to their Deepana, Pachana and Vatanulomana properties. Objective: The objective of this work is to analytically standardize Ajamoda Arka with Yavakshara by testing its organoleptic, physicochemical, chromatographic, microbial properties, Heavy metal and Pesticides following standard guidelines. Materials and Methods: The preparation of Ajamoda Arka is done according to “Arka Kalpana” given in AFI. Yavakshara prepared using AFI guidelines is mixed with distilled Ajamoda Arka in a specific ratio. “Organoleptic characters”, “clarity”, “pH”, “specific gravity”, “refractive index”, “viscosity”, “volatile matter”, “total acidity”, HPTLC, GCMS, “Heavy metals”, “Pesticides” were done using API guidelines. Results:Ajamoda Arka with Yavakshara was clear, colourless and aromatic with salty taste. Physicochemical parameters showed pH 6.34, specific gravity 0.9710, refractive index 1.32507 and viscosity 1.01, indicating stability of the formulation. Volatile matter was 0.13%. Microbial analysis revealed absence of bacterial and fungal growth, confirming microbiological safety within permissible limits. HPTLC analysis reported characteristic bands analogous to α-phellandrene and β-pinene. GC–MS chromatogram revealed several constituents including 9-Octadecenoic acid derivatives, ‘cis-9-Hexadecenal, terpen’ and ‘glycidyl palmitate’, indicating the presence of anti-inflammatory bioactive compounds. Heavy metals were within permissible limits and all tested pesticides were negative, confirming the safety of the formulation. Conclusion:The present study establishes preliminary analytical standards and chromatographic fingerprints for Ajamoda Arka with Yavakshara. The results of this pharmaceutical study can serve as criteria for ‘quality control’ and ‘standardization parameter’ for future research. However, further studies can be enriched with safety and stability evaluation for shelf life.
Introduction Tilvaka (Viburnum nervosum D. Don.) belongs to the family Caprifoliaceae. It is a deciduous shrub of Himalayan and north-eastern regions of India. In classical texts, it is mentioned under Shyamadi Gana and shat sodhana vriksha (purifying trees), indicating its purgative property. It is an ingredient of formulations like Arguvadi taila, primarily indicated for vata vyadhi (Diseases due to vata imbalance), pandu roga (anaemia)and udara roga (abdominal diseases), etc. The current review compiled the data on Tilvaka and evaluated its traditional claims in light of modern findings. Methodology Data were collected and compiled from classical Ayurvedic texts, scientific literature, ethnobotanical data, and pharmacological reports from databases, including PubMed and Web of Science. Information on identification, traditional uses, phytoconstituents, and therapeutic intervention was analysed. Result Tilvaka is a medicinal shrub of the Himalayan region of India. It is also known by other names like Telam, Thelka and Asara. It has purgative action. In classical and folk medicine, different parts- bark, fruit, and the whole plant are used to treat various conditions like anaemia and dysmenorrhea, etc. Phytochemical studies have confirmed its antioxidant, antimicrobial, and anti-cancerous activity due to the presence of compounds- terpenoids, triterpenoids and bergenin. Discussion Tilvaka is a Himalayan medicinal plant that was confused with Lodhra, later identified as Viburnum nervosum by Thakur Balwant Singh. It is a mild virechaka (purgative) drug with ovate leaves and drupe fruit. In folklore, its fruit, root, and bark are used in anaemia and GIT disorders and is key ingredients of formulations like Tilvaka ghrta and Pippalayadi kshara. Phytochemically, it contains terpenoids, glycosides, etc. responsible for possessing antimicrobial and antioxidant activities. Conclusion Tilvaka is classical drug used in conditions like Pandu, Krimi and Kustha. It is an endangered species, requires complete Pharmacognostical-phytochemical profiling along with propagation and conservation techniques for future use.
Background: Schizoaffective disorder, depressive type with comorbid alcohol use disorder, is a complex condition with overlapping psychotic, mood, and substance-use symptoms. Diagnosis and management are challenging. In Ayurveda, it aligns with Sannipataja Unmada, where there is a coexistence of psychotic and mood symptoms, including both positive symptoms like hallucinations, delusions, and negative symptoms like social withdrawal, impaired cognition, blunted affect, and it's a highly debilitating condition. Clinical findings: A 50-year-old alcoholic male with a known case of Type 2 Diabetes Mellitus and Hypertension for 15 years, on treatment with irregular adherence leading to suboptimal glycaemic and blood pressure control, presented with longstanding low mood, frequent anxiety, occasional hallucinations, paranoid ideation, and persistent alcohol use despite repeated medical advice. Mental health examination revealed impaired memory and concentration, partial insight, and mild psychomotor agitation. Standardised assessments revealed moderate-to-severe depressive symptoms (HDRS), mild anxiety, harmful drinking (AUDIT), cognitive impairment (MMSE), and positive suicidality (C-SSRS). Based on clinical presentation and ICD-11, Schizoaffective Disorder, Depressive Type with Alcohol Use Disorder was diagnosed. Intervention: protocol was administered alongside ongoing pharmacotherapy. This included Panchakarma (Nasya), external therapies (Shirodhara, Shiropichu, etc.), Shamana medicines (Brahmi Vati, Draksharishtam, etc.), Satwawajaya Chikitsa (psychotherapy), Marma therapy, and Yoga. Outcome: The patient showed significant overall improvement over 90 days of treatment, with cognitive function (MMSE) improving by 43.8%. There was a marked reduction in depressive (65.4%), anxiety (50%), insomnia (33.3%), alcohol use (46.7%), suicidality (90.9%), and psychotic symptoms (34.9%). These findings indicate clinical recovery and stabilization, but not remission, and thus require continued management. Alcohol dependence made abstinence challenging, though intake was reduced, with the last use before admission. Conclusion: A multidimensional Ayurvedic treatment approach can help to address and manage diagnostic and therapeutic challenges in schizoaffective disorder with alcohol use disorder. While outcomes are promising, validation through larger controlled studies is required.
Background: The changeover from higher secondary education to professional medical education requires significant changes in psychological, social, and academic components. Ayurveda as a profession is a lifelong commitment to connect deeply with classical texts and guide needy patients in their journey of healing. The students choosing a B.A.M.S. need to study the core of Ayurveda texts along with the modern perspectives and practices. Recognizing the challenges faced by young and new students, NCISM implemented the transitional curriculum “Ayurpraveshika -2025-2026” for first-year undergraduates. Objectives: This narrative review explores the current status of the “Ayurpraveshika 2025-26 transitional curriculum," the need for its implementation, and gaps to be addressed in the future. Methods: Related literature was identified through PubMed, Scopes, Google Scholar, and Research Gate using keywords "transitional curriculum" and "Ayurveda," which were reviewed to summarize trends, applications, and ethical concerns. Conclusion: The primary need for this curriculum arises as students entering this course are from diverse educational backgrounds, have limited exposure to Sanskrit-based classical texts, are unacquainted with Ayurveda's basic concepts and its future opportunities, are unaware of medical terminologies, and have inadequate preparation for the rigorous professional learning environment. This transitional curriculum is essential to improve learner confidence, make them goal-oriented right from the 1st year, reduce fear and anxiety of Ayurveda concepts, enhance academic and clinical skills, ignite the curiosity of health services, research, and entrepreneurship, and ensure holistic development among students with mindfulness.
Background: Nasya Karma which is one among the Panchakarma, has got an important role in the management of Urdhvajatrugata Vikara. Ayurvedic classics also describe the dissemination of Nasya Dravyas (drugs) through Shringataka Marma and various channels, indicating its potential for systemic action including Vata Vyadhi. Objectives: To highlight specific Ayurvedic formulations for Nasya and exploring its role in managing Vata Vyadhi. Methods: A critical manual review of classical Ayurvedic texts, including Brihattrayi, Laghutrayi and various Uttarkalina Samhitas for Nasya in Vata Vyadhi revealed 74 different entries. All 74 indications are analysed according to different formulations in various Vata Vyadhi w.s.r. to neurological disorders. Results: Out of 74 formulations, 30 formulations are mentioned in Brihattrayi and Uttarkalina Samhita each, followed by 14 Yoga in Laghutrayi. Maximum formulations i.e. 64 are of Sneha Kalpana, out of which 53 are of Tail followed by 9 of Ghrita, 1 of Vasa and Majja each. In addition to Sneha Kalpana, 5 of Swarasa, 3 of Kwatha, 1 formulation each of Churna and Sheetal Jala is mentioned. Conclusion: The analyzed classical references support the potential of Nasya in the management of Vata Vyadhi w.s.r to neurological disorders. Specifically, the results indicate the potential of Snehana Nasya in the management of various Vata Vyadhi, as formulations having Sneha predominance are repeatedly mentioned across different Ayurvedic texts.
Background: Generalized Anxiety Disorder is a common mental health condition characterized by persistent and excessive worry, restlessness, irritability, fatigue, difficulty concentrating, muscle tension, disturbed sleep, and impaired daily functioning. In Ayurveda, these symptoms resemble Chittodvega, caused by imbalances of the Vata and Pitta Doshas and an excess of Rajo Guna, which disrupts the Manovaha Srotas. Psychosocial stressors such as emotional neglect and interpersonal conflicts act as important nidanas in the development of the condition. Clinical findings: A 57-year-old married homemaker presented with a two-year history of persistent and excessive worry, apprehension, grief, irritability with occasional anger outbursts, emotional suppression, lethargy, disturbed sleep, and symptoms as mentioned above. Her psychosocial history included emotional dependence on her children, marital conflicts, perceived criticism, and long-term emotional suppression, which had a more impact. The Mental Status Examination revealed an anxious mood, restricted affect, psychomotor agitation, and ruminative thoughts, with preserved insight. According to the DSM-5, she was diagnosed with GAD. Intervention: The patient received a combined Ayurvedic treatment integrating Yukti Vyapashraya Chikitsa and Sattvavajaya Chikitsa. Shamana therapies included Manasamitra Vati, Vishamushti Vati, and Maha Rasnadi Kashaya, along with Panchakarma procedures such as Sarvanga Abhyanga, Swedana, Shirodhara, Shiropichu, and Basti. Sattvavajaya strategies involved Yoga Nidra, art therapy, music therapy, positive affirmations, and structured counseling for herself and her spouse. Outcomes: Marked improvements were observed in HAM-A, HAM-D, and ISI scores, decreasing from 25 to 4, 18 to 1, and 19 to 0, respectively, indicating a substantial reduction in anxiety, depression, and insomnia. Patient experienced improvement in sleep quality, emotional stability, confidence level, and QOL. Conclusion: This case illustrates that an integrated Ayurvedic approach combining Yukti Vyapashraya and Sattvavajaya Chikitsa can effectively treat Chittodvega (GAD) by balancing the tridoshas and addressing maladaptive thoughts, thereby improving psychological resilience and overall well-being.
Background: Chronic venous ulcers are caused by valvular incompetence and are considered as serious complication of chronic venous insufficiency (CVI) which can lead to cellulitis, infections, osteomyelitis and eventually require amputation. Ulcer (Vrana) in Ayurveda has been explained in detail by Acharya Susruta. In this case, it denotes chronicity, painful), discharge, and is associated with venous system, etc. were suggestive of sirajanya dushtavrana (chronic venous ulcer). Ayurvedic interventions focused on shodhana and ropana therapies. Clinical findings: A 61-year-old non diabetic female presented with chief complaints of a non-healing ulcer of size 15X8X0.5 cm with pain and discharge above the medial malleolus of the right lower limb, and was diagnosed as sirajanya dushtavrana. She had the same history two years back and had taken treatment, but the condition persisted with delayed healing. Intervention: Treatment initiated with rookshana karma (dry inducing therapy) and Deepana (Digestion stimulating) medicines, snehapana (internal oil therapy) virechana (purgation therapy) followed by basti (medicated enema) and Vrana Basti were adopted along with proper wound care and internal medications. Outcomes: Wound healed completely with tissue epithelialization, scar formation and significant reduction in pain was achieved without any complications, in duration of 30 days of treatment, and 5 months of follow-ups. Follow-up was uneventful. Conclusion: This case demonstrates successful management of chronic venous ulcer of size 15x8x0.5 cm is completely healed and change of VAS from 6 to 0. using a multimodal ayurvedic approach, including classical snehapana, virechana, basti, Vrana Basti and internal medications. Treatment duration was approximately 30 days and 5 follow-ups were done in every month, with no adverse effects and recurrence. Complete healing was achieved in 6 months. This case suggests the efficacy of holistic ayurvedic therapies and proper wound care in the management of long-standing venous ulcers.
Background: Durva Taila is a formulation which is described in classics for the management of wounds, bleeding, and inflammation. It is being used till now for the treatment of various diseases. As per the classics, sesame oil has to be used in the preparation of Durva Taila but in the present analytical study coconut oil is used as base because it has Madhura rasa and sheeta virya which could have better effects in wound healing. As this formulation lacks a systematic analysis of its chemical composition so by using modern analysis methods, we can provide its true potential in wound care and attain the greater acceptance of this Ayurvedic formulation. Materials & Methods: A 100ml sample of Durva Taila was prepared, with slight change choosing coconut oil as base instead of Sesame oil, following classical Ayurvedic procedures. Under standard protocols, GC-MS analysis was carried out to recognize volatile and semi-volatile phytoconstituents present in the formulation. Results & Discussion: The GC-MS analysis revealed a complex mixture of compounds including fatty acid esters, hydrocarbons, aldehydes & phytosterols derivatives. Total 26 key bioactive molecules at different retention time were identified which included 2-Heptanone,2-decenal,(E)-, Glycidyl palmitoleate, Dodecanoic acid (lauric acid), Pentadecanoic acid, δ-dodecalactone, 9-Octadecenamide, (Z)-, Pinoresinol, dimethyl ether (also known as (+)-eudesmin), etc. which are well established for their anti-inflammatory, anti-nociceptive/analgesic, anti-microbial, anti-oxidant, tissue repairment and regenerative properties. The presence of these multiple bioactive phytoconstituents suggests a cumulative synergistic mechanism underlying the therapeutic effects of Durva Taila. Conclusion: The isolation and identification of these bioactive compounds provides strong scientific evidence supporting the use of Durva Taila in wound healing and inflammation- analgesia management. This further encourages pharmacological and clinical studies in vivo and human trials to validate its potency and delve into potential integration to modern therapeutics.
Background: Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder comes under purview of Obesity hypoventilation Syndrome (OHS) categorized by recurrent upper airway obstruction during sleep, resulting in snoring, excessive daytime sleepiness, fatigue, and impaired quality of life. Obesity is a major risk factor for OSA and contributes significantly to disease progression. Clinical Findings: A 38-year-old obese male (Body Mass Index (BMI) 32.5 kg/m²) presented with loud snoring, excessive daytime sleepiness, fatigue, drowsiness, disturbed sleep, recurrent upper respiratory symptoms, and progressive weight gain over six years. The patient had experienced two road traffic accidents secondary to excessive sleepiness while driving. STOP-BANG and Berlin questionnaires indicated a high risk of OSA, while the Epworth Sleepiness Scale (ESS) score was 16, suggesting excessive daytime sleepiness. Interventions: The patient underwent a multimodal Ayurvedic treatment protocol comprising Udwartana (powder scrubbing) Utsadana (oil mixed powder scrubbing) Parisheka (Pouring of Medicated decoction externally) Pradhamana Nasya with Vacha Churna (Nasal Instillation of Powder Drugs) and Lashuna Swarasa, Shadbindu Taila Nasya, Snehapana (Internal Oleation) with Panchatikta Guggulu Ghrita, Virechana (Therapeutic Purgation) internal medications (Vyoshadi Vati, Triphala Guggulu), and yoga practices including selected asanas and pranayama. Post-discharge medications and lifestyle modifications were advised. Outcome Marked improvement was observed in snoring, daytime sleepiness, fatigue and sleep quality. ESS score reduced from 16 to 0, Berlin Questionnaire categories changed from positive to negative, and STOP-BANG responses showed good clinical improvement. BMI decreased from 32.5 to 28.35 kg/m². No adverse events were reported. Conclusion This case demonstrates the potential role of a comprehensive Ayurvedic approach incorporating Panchakarma, internal medications and yoga in the management of obesity-induced OSA. Significant improvements were observed in clinical symptoms, sleep-related outcomes- Epworth Sleepiness Scale, Berlin Questionnaire Categories and body weight without any adverse effects, further large studies are warranted in order to validate this finding.
Background: Polyherbal formulations play a pivotal role in Ayurveda therapeutics; while their complex phytochemical composition demands analytical validation for their quality and safety. Pharmaceutical development of classical Ayurveda formulations to advanced dosage forms is the dire need for enhanced patient compliance. Aim: To develop a polyherbal oil and its topical derivatives (gel and ointment) and comparatively characterize their phytochemical fingerprints using LC–MS analysis. Methods: The Polyherbal oil was prepared by following the basic principles of Sneha kalpana(oil and ghee preparations) and its conversion to gel and ointment were done by the contemporary principles and their comparative analytical evaluation is carried out using Liquid Chromatography–Mass Spectrometry (LC-MS) under identical chromatographic conditions. Results: LC-MS analysis revealed the presence of flavonoids, terpenoids, phenolic glycosides, sterols, and fatty acids across all formulations. Polyherbal oil demonstrated broader phytochemical diversity with compounds such as α-pinene, harmol, curdione, campesterol, and lupeol, while the ointment and gel retained selective phytoconstituents including glyasperine D, syringing, homoorientin, lupeol derivatives, flavonoids glycosides, and isoflavonoids. Comparative analysis showed partial retention of key phytochemical groups despite formulation modifications. Conclusion: The study demonstrated retention of major phytochemical groups across all formulation dependent variations in LC-MS profiles. LC-MS fingerprinting was found useful for comparative phytochemical evaluation of topical dosage forms.
Background: In Ayurveda, 'Gada' refers to the disease or suffering, whereas 'Agada' refers to antidote which alleviates the effect of the disease or poison exposed locally or internally. There are various Agada or antidote formulations which are indicated to counteract both animate and inanimate poisons in Agada tantra (Clinical Toxicology). This branch is among the eight branches of Ayurveda and that is Ashtanga Ayurveda which commonly deal with bites and poison management. Vanshatwakadi Agada is one such formulation referenced from the Sushruta Samhita Kalpa-sthana (Sarpadashta Visha Chikitsa), indicated in Loota Visha (spider bite poison). The Agada combine eleven ingredients - Vansha twak (Bambusa arundinacea Willd.), Amalaki (Emblica officinalis Gaertn.), Kapitha (Feronia limonia Linn. Swingle), Kushtha (Saussurea lappa C.B. Clarke), Shunthi (Zingiber officinale Roxb.), Maricha (Piper nigrum Linn.), Pippali (Piper longum Linn.), Hemavati (Acorus calamus Linn.), Karanja (Pongamia pinnata Linn Merr.), Tagara (Valeriana wallichii DC), Shirisha (Albizzia lebbeck Bent.) with cow’s bile to alleviate sign and symptoms of Loota Visha. This article aims to discuss the role of Vanshatwakadi Agada as an antidote for reducing sign and symptoms of Loota Visha by analysing the pharmacological property and therapeutic utility of individual ingredients. Materials and methods: Several classical texts were referenced including Sushruta Samhita, Ashtanga Hridya, Ashtang Sangraha, Bhavapraksha Samhita, Sharangdhara Samhita and textbooks like Dravyaguna Vigyana and Agada Tantra. Jangama Visha, Loota Visha, Agada formulation, Chikitsa etc. were used as search terms in database search. Conclusion: The Vanshatwakadi Agada given in Sushruta Samhita have potential role in managing Loota Visha symptoms. The pharmacological characteristics and medicinal properties of Vanshatwakadi Agada are highlighted in this article in relation with contemporary concepts.
