The circadian clock orchestrates biological rhythms across species and is deeply involved in the physiological and biochemical processes underlying tumor initiation and progression. By regulating cell division, DNA repair, immune function, and hormonal balance, circadian rhythms interact closely with cancer, providing a theoretical foundation for the exploration of chronotherapy. Maintaining circadian homeostasis is therefore essential for cancer prevention and treatment. This review centers on the intricate relationship between circadian rhythms and malignancy, with a particular focus on the role of circadian disruption in tumorigenesis and malignant progression. A systematic literature search was performed across the PubMed, MEDLINE, and Scopus databases to screen original studies and review articles focusing on circadian regulation in colorectal cancer. This review delineates the tissue-specific effects of circadian clock signaling in colorectal malignancy and clarifies the correlation between circadian disruption and early tumorigenesis. Accumulated evidence is integrated into a comprehensive mechanistic framework covering metabolic reprogramming, tumor immunosuppression, and stromal remodeling. Additionally, current advances in harnessing circadian rhythms to refine preventive strategies and chronotherapeutic regimens for colorectal cancer are highlighted, with a concise discussion on the potential of traditional Chinese medicine in regulating biological rhythms to improve colorectal cancer clinical management.
Background:Central venous pressure (CVP)-guided fluid therapy remains common during kidney transplantation, although CVP is a static marker with limited ability to predict fluid responsiveness. This prospective observational cohort study evaluated whether pulse index continuous cardiac output-guided goal-directed hemodynamic therapy (GDHT), using dynamic and volumetric hemodynamic variables, was associated with improved early graft function compared with conventional CVP-guided management in living donor kidney transplantation. Methods:Eighty living donor kidney transplant recipients at Cho Ray Hospital, Vietnam, were enrolled between May 2024 and December 2025. Patients were managed according to the institutional anesthetic monitoring protocol in use at the time of surgery: CVP-guided fluid therapy (group C, n = 40) or PiCCO-guided GDHT (group P, n = 40). The PiCCO protocol incorporated stroke volume variation, pulse pressure variation, cardiac index, global end-diastolic volume index, systemic vascular resistance index, and extravascular lung water index. Outcomes included intraoperative fluid volume, vasopressor use, postoperative urine output, serum creatinine through postoperative day 7, delayed graft function, and postoperative complications. Results:Baseline recipient, donor, and operative characteristics were comparable between groups, with the exception of cold ischemia time, which was longer in group P. Total intraoperative fluid volume was lower in group P than in group C (2,656 ± 480 mL vs. 3,097 ± 555 mL; P = 0.001), and vasopressor use was numerically lower but not statistically significant (12.5% vs. 27.5%; Fisher's exact P = 0.161). First-hour postoperative urine output was higher in group P (1,235 ± 162 mL vs. 1,010 ± 315 mL; P < 0.001). Serum creatinine was similar on postoperative day 1 but was significantly lower in group P on day 3 (1.3 (0.8-1.8) mg/dL vs. 1.6 (1.4-1.9) mg/dL; P = 0.036); the difference on day 7 was not statistically significant (1.1 (0.7-1.4) mg/dL vs. 1.3 (1.1-2.1) mg/dL; P = 0.16). No patient in either group developed delayed graft function within 7 days. Extravascular lung water index remained within the reference range during surgery, and no patient developed clinical pulmonary edema. Conclusions:In this prospective cohort, PiCCO-guided GDHT was associated with lower intraoperative fluid administration, numerically lower vasopressor use, and faster early recovery of graft function after living donor kidney transplantation. These findings support further evaluation of multiparameter hemodynamic monitoring as an individualized perioperative strategy in kidney transplantation.
Background:Dysmenorrhea negatively affects daily functioning; however, its association with restorative sleep remains undetermined, while sleep-related health is a recent topic. This study investigated whether there is an association between dysmenorrhea severity and the absence of restorative sleep in women. Methods:This cross-sectional study included 2,752 women of 18-56 years of age who underwent health-screening. Dysmenorrhea was categorized as mild, moderate, or severe, based on self-reports. Restorative sleep was evaluated using a questionnaire regarding sufficient rest from sleep. Their associations were tested using a logistic regression analysis adjusted for confounders with odds ratio (OR) and 95% confidence interval (CI). Results:Restorative sleep was absent in 38.4% of this population. There was a significant association between severe dysmenorrhea and the absence of restorative sleep (adjusted OR 2.282, 95% CI 1.744-2.986; P < 0.001). There was also a significant association between moderate dysmenorrhea and the absence of restorative sleep (adjusted OR 1.241, 95% CI 1.049-1.467; P = 0.012). Conclusions:The results indicated a positive association between dysmenorrhea severity and the absence of restorative sleep in women. The evaluation of restorative sleep may be relevant to health checks in association with dysmenorrhea.
Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive and life-threatening condition caused by extracellular deposition of misfolded transthyretin protein in cardiac tissue. Once considered rare and universally fatal, ATTR-CM has emerged as an increasingly recognized cause of heart failure, particularly among older adults. Recent therapeutic advances have transformed the management landscape from purely symptomatic care to disease-modifying interventions targeting multiple pathogenic mechanisms. This narrative review synthesizes current evidence on pharmacologic strategies for ATTR-CM, including transthyretin stabilizers such as tafamidis and acoramidis, gene-silencing therapies including patisiran, vutrisiran, and eplontersen, fibril disruptors, and emerging amyloid-depleting monoclonal antibodies and gene-editing approaches. We examine pivotal trial data demonstrating improvements in survival, functional capacity, and quality of life, alongside ongoing challenges related to safety, cost, and equitable access. The convergence of early diagnosis through improved imaging and biomarker strategies with targeted therapeutics has substantially changed the outlook for patients with a previously untreatable disease. Future directions emphasize combination therapies, biomarker-guided treatment selection, and precision medicine approaches tailored to disease genotype and phenotype.
Background:Retinal artery occlusion (RAO) shares vascular pathophysiology with cerebrovascular disease, and its relationship to incident dementia remains unsettled. Reported associations may reflect shared vascular pathology, differential ascertainment along the intensive workup pathways that RAO patients enter, or both. No prior study has calibrated RAO-dementia estimates against prespecified negative-control outcomes spanning distinct ascertainment pathways. Methods:Among 129,279 All of Us participants aged 50 years or older and free of prevalent dementia (controlled-tier release R2024Q3R9, OMOP common data model), strict RAO was defined by seven verified SNOMED concept identifiers (n = 339). Incident dementia required two or more codes at least 30 days apart (Wilkinson algorithm), with prespecified vascular and Alzheimer subtypes. Cox models used age as timescale with left truncation and time-varying exposure; 1:5 propensity-score matching was the primary confounder-adjusted analysis. Cataract, benign paroxysmal positional vertigo (BPPV), and inguinal hernia were prespecified negative controls for ophthalmology, neurology, and general-contact pathways. Results:There were 1,506 incident dementia events. RAO was not associated with all-cause dementia (unmatched hazard ratio (HR) 0.81, 95% confidence interval (CI) 0.40-1.64; matched HR 1.33, 95% CI 0.72-2.47; 10 exposed events). The vascular dementia estimate remained elevated but imprecise (unmatched HR 1.93, 95% CI 1.02-3.66; matched HR 1.81, 95% CI 0.66-4.94; 3 exposed events). Cataract was elevated (HR 1.87, 95% CI 1.45-2.42), whereas BPPV (HR 1.27, 95% CI 0.90-1.79) and hernia (HR 1.10, 95% CI 0.68-1.78) were not. Conclusions:We found no evidence that RAO is independently associated with incident dementia, replicating a large European null finding in a diverse United States cohort. The cohort was underpowered to exclude clinically meaningful effects, particularly for vascular dementia. Detection bias in this dataset was demonstrably pathway-specific, but same-pathway calibration accounts for only part of the residual vascular dementia estimate.
Background:This study aimed to develop a nomogram, a visual prediction model to predict the risk of postoperative pneumonia (POP) in elderly patients after hip fracture surgery. Methods:A retrospective analysis was conducted on 711 patients aged 65 and over who underwent surgery for hip fractures. A logistic regression analysis with a nomogram was used to identify independent risk factors for POP. Results:Out of the studied patients, 26 (3.7%) developed POP after surgery. Independent risk factors for POP included age, gender, body mass index (BMI), serum albumin levels, change in inflow E and mitral e' annular velocities (E/e'), severity of fracture (fractured) and administration of diuretics. The results of both univariate and multivariate logistic regression analyses revealed that age, gender, serum albumin levels and diuretics showed significant increase in odds ratio, whereas no significant differences were found in BMI, E/e' and fractured in odds ratios in POP patients. The area under the curve (AUC) of the nomogram model was 0.838, indicating discriminative ability. Conclusions:The nomogram developed in this study predicted the risk of POP in elderly patients with hip fractures. Using this model in clinical practice could allow for appropriate preventive measures to be taken for high-risk patients, potentially reducing the incidence of POP and improving patient outcomes.
Background:The study aimed to develop risk stratification models for diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus (T2DM) using multiple machine learning algorithms, identify the optimal model, and visualize it through a nomogram, thereby providing a clinical decision-support tool for the early identification of high-risk individuals. Methods:A retrospective analysis was conducted on 180 inpatients diagnosed with T2DM at the Endocrinology Department of our hospital from January 2021 to September 2024, including 88 patients with DPN (48.9%) and 92 patients without DPN (51.1%). All enrolled participants were randomly divided into a training cohort (n = 126) and an internal validation cohort (n = 54) at a 7:3 stratified ratio. Collected clinical variables covered demographic profiles (age, gender, diabetes duration), anthropometric indicators (body mass index (BMI)), and multiple laboratory biomarkers. Five predictive algorithms were adopted for model construction, namely logistic regression (LR), random forest (RF), extreme gradient boosting (XGBoost), support vector machine (SVM), and decision tree (DT). Model predictive efficacy was comprehensively assessed using receiver operating characteristic (ROC) curves, calibration curves, decision curve analysis (DCA), and SHapley Additive exPlanations (SHAP) interpretability analysis. A visual nomogram was finally developed based on the best-performing model. Results:Multivariate regression analysis screened out six independent predictive factors for DPN occurrence, including diabetes duration, glycated hemoglobin (HbA1c), microalbuminuria (MAU), low-density lipoprotein cholesterol (LDL-C), neutrophil percentage (NEUT%), and BMI (all P < 0.05). Among all established models, the XGBoost algorithm yielded the best predictive outcomes in internal validation, with an area under the curve (AUC) of 0.903 (95% confidence interval (CI): 0.816-0.986), accuracy of 85.2%, sensitivity of 84.6%, and specificity of 85.7%. Its predictive efficacy was numerically superior to that of RF (AUC = 0.808), LR (AUC = 0.838), SVM (AUC = 0.884), and DT (AUC = 0.814). SHAP analysis further identified diabetes duration, HbA1c, and MAU as the most influential predictors for DPN risk. The nomogram established based on these core variables achieved a validation AUC of 0.85, with favorable calibration efficiency (Hosmer-Lemeshow P = 0.512) and positive net clinical benefit across a wide range of threshold probabilities. Conclusion:The XGBoost-based model shows favorable preliminary performance for cross-sectional DPN risk stratification in T2DM patients based on internal hold-out validation, outperforming traditional statistical approaches. Combined with SHAP interpretability and nomogram visualization, this model provides an exploratory clinical tool for early identification of potential high-risk individuals, requiring further external validation before clinical application.
Objective: To investigate the value of cardiac magnetic resonance feature tracking (CMR-FT) in assessing left heart function in hypertensive heart disease (HHD) patients and to preliminarily explore the relationship between left atrial (LA) and left ventricular (LV) function1. Methods: Ten Bama minipigs were randomly divided into an experimental group (N=6) and a control group (N=4). The experimental group underwent laparotomy with left renal artery ligation to establish a hypertension model, whereas the control group underwent laparotomy without ligation. CMR-FTs were performed at baseline and at 16 weeks post-surgery. Global LA and LV functional parameters were measured via CVI42 postprocessing software. Results: Left atrial volumetric indices LAVImin and LAVImax were significantly greater in the hypertension group at 16 weeks (LAVImin 17.65±1.66 vs 11.13±1.60 mL/m², P<0.001; LAVImax 27.05±2.19 vs 20.75±3.13 mL/m², P=0.005). LA reservoir and conduit function deteriorated early: εs and εe were decreased at 16 weeks (εs 27.22±3.71 vs 39.53±2.72, P<0.001; εe 12.10±2.02 vs 23.00±1.77, P<0.001). LV volumetric parameters and LVEF remained comparable between groups at all time points (all P>0.05), whereas LV strain indices were significantly impaired in the hypertension group at 16 weeks (e.g., LVRS 29.55±1.80 vs 43.18±1.35; LVCS −16.58±0.87 vs −19.63±0.99; LVLS −12.63±1.73 vs −18.33±0.76; all P≤0.039). Moreover, the LVLS was positively correlated with εs (r=0.814) and εe (r=0.875) and negatively correlated with LA volume (LAVmin r=−0.817; LAVmax r=−0.907), whereas the LVRS was also associated with LA function (all P<0.05). Conclusion: CMR-FT can detect structural and functional impairments of the LA and LV in early-stage HHD earlier, more sensitively, and more accurately than conventional cardiac functional parameters. Furthermore, significant correlations exist between LA and LV functional parameters.
Objective: To observe the clinical efficacy of Zuojin Yifan Granules in the treatment of reflux esophagitis (liver stomach stagnation heat syndrome). Method: 108 patients with reflux esophagitis (liver stomach stagnation heat syndrome) were randomly divided into Group A, Group B, and Group C using a random number table, with 36 patients in each group. Group A received treatment with Zuojin Yifan Granules, Group B received treatment with Zuojin Yifan Granules combined with rabeprazole, and Group C received treatment with rabeprazole for 8 weeks. Clinical symptom scores between groups and within groups were compared, and the improvement of clinical symptoms and changes in esophageal mucosa under endoscopy were observed in patients. Result: Before treatment, there was no statistically significant difference in clinical symptom scores among the three groups (P>0.05). After treatment, the clinical symptom scores of the three groups improved compared to before treatment. The clinical symptom scores of Group B were lower than those of Group A and Group C (P<0.05), and the clinical symptom scores of Group A were lower than those of Group C (P<0.05). The total effective rate of clinical symptom improvement in Group B was higher than that in Group A (P<0.05), and the total effective rate of clinical symptom improvement in Group A after treatment was higher than that in Group C (P<0.05). The total effective rate of endoscopic efficacy in Group B was higher than that in Group A (P<0.05), and the total effective rate of endoscopic efficacy in Group A was higher than that in Group C (P<0.05). Conclusion: The clinical effect of Zuojin Yifan Granules in the treatment of reflux esophagitis (liver stomach stagnation heat syndrome) is ideal, which can significantly improve clinical symptoms and enhance the endoscopic efficacy of patients.
This study explored the impact of systematic nutritional support nursing intervention on nutritional status, quality of life, complication rate, and nursing satisfaction in critically ill cancer patients, providing clinical evidence for optimizing nutritional nursing programs for ICU patients with critical cancer. A prospective randomized controlled study was conducted, selecting 88 critically ill cancer patients admitted to the ICU of our hospital from January 2024 to December 2024. They were randomly divided into an observation group and a control group, with 44 patients in each group. Nutritional indicators (serum albumin, prealbumin, hemoglobin), Karnofsky Performance Status (KPS) scores, complication rates, and nursing satisfaction were compared between the two groups before and two weeks after the intervention. Systematic nutritional support nursing intervention can effectively improve the nutritional status of critically ill cancer patients, reduce the risk of nutrition-related complications, and improve patients' quality of life and nursing satisfaction.
Objective: To systematically review the latest research findings on cardiac computed tomography (CT) in terms of hardware innovation, intelligent technology integration, and expanded clinical applications. This review emphasizes its value in precision diagnosis and treatment for conditions such as atrial fibrillation and aortic valve stenosis, providing reference for the advancement of precision medicine in cardiovascular diseases. Methods: We retrieved data from core domestic and international journals, multicenter clinical trials, and authoritative guidelines (ESC, ACC/AHA, Chinese Medical Association Radiology Branch) published between 2021 and 2025. Analyses focused on technological breakthroughs in cardiac CT and disease-specific assessments through AI integration. Results: Dual-slice dual-source CT and photon-counting detector CT (PCD-CT) achieved the integration of low dose and high resolution, while AI technology revolutionized the entire image reconstruction workflow. CT demonstrates critical value in pre-ablation assessment for atrial fibrillation and throughout transcatheter aortic valve replacement (TAVR) for aortic stenosis. Left atrial appendage volume >9.25 ml serves as an independent predictor of post-ablation recurrence (HR=1.160, 95% CI: 1.095–1.229, P<0.001).An independent predictor of post-ablation recurrence (HR=1.160, 95% CI: 1.095–1.229, P<0.001). Pre-TAVR CT assessment achieves over 95% accuracy in valve selection. Recommendations for CCT differ between the 2024 ESC and ACC/AHA guidelines, with ACC/AHA's Class COR-IIa recommendation rate (51.9%) significantly higher than ESC's (35%) (P=0.04). Conclusion: Cardiac CT has evolved into an integrated diagnostic and therapeutic platform characterized by "intelligence, precision, and comprehensive care." Future efforts should focus on advancing technical standardization and improving accessibility at the primary care level to enhance its role in early disease screening and personalized treatment.
Astragalus membranaceus, a treasured herb in traditional Chinese medicine, has garnered extensive attention for its immunomodulatory properties in both clinical and experimental settings. Among its bioactive constituents, triterpenoid saponins such as astragaloside are recognized as the principal agents underlying its therapeutic efficacy. This review systematically summarizes the current research progress on the immunoregulatory effects of astragaloside and related triterpenoid saponins derived from Astragalus. We begin by outlining the historical and pharmacological background of Astragalus and its key active components. Subsequently, the review delves into the modulation of innate and adaptive immune responses by astragaloside, highlighting the molecular mechanisms and signaling pathways involved. Additionally, recent pharmacological findings and potential clinical applications are discussed to provide a comprehensive understanding of these compounds’ roles in immune regulation. This synthesis aims to offer a theoretical framework to guide future investigations and the development of Astragalus-based immunotherapeutics.
Ichthyosis, known in Traditional Chinese Medicine (TCM) as "snake-skin lichen," is a condition historically described as scaly skin resembling snake scales. Pathogenic Wind causes this condition by obstructing the striae, which leads to sluggish blood and qi and a failure to moisturize the skin. This study explores the TCM perspective on ichthyosis and evaluates the efficacy of Zhang Jian Therapy, a treatment developed through 23 years of clinical practice. This therapy identifies the root cause in the kidneys, the root basis in the spleen, and the superficial manifestation in the lungs. As a patented TCM external treatment in both China and the U.S., it uses a unique fumigation method to activate a patented herbal formula, allowing rapid skin penetration. Clinically validated, it achieves therapeutic results approximately 20 times more effective than conventional oral medications or skincare products. It overcomes the limitations of Western treatments, which are rapid-acting but have significant adverse reactions, and traditional remedies, which are slow-acting. By improving both the skin and internal organs without harming the liver, spleen, or kidneys, Zhang Jian Therapy delivers remarkable outcomes and addresses the core imbalance of yin and yang in ichthyosis.
Objective: To investigate the effects of two different ventilation methods on ventilation function in preterm infants with respiratory distress syndrome (RDS) during the recovery period. Methods: 100 preterm infants with respiratory distress syndrome (RDS) admitted to the neonatal intensive care unit of our hospital from January 2022 to January 2025 were selected as the study subjects. According to the random number table method, they were divided into high-frequency oscillatory ventilation combined with volume guarantee (HFOV-VG) group (50 cases) and conventional mechanical ventilation (CMV) group (50 cases). Compare the invasive mechanical ventilation time and total respiratory support time, arterial blood gas analysis results [arterial oxygen partial pressure (PaO₂), carbon dioxide partial pressure (PaCO₂), inspired oxygen fraction (FiO₂)], and the occurrence of adverse reactions between the two groups. Results: Both invasive mechanical ventilation time and total respiratory support time in HFOV-VG group were shorter than those in CMV group (P<0.05). The PaO₂ levels in the HFOV-VG group at 6h, 12h, and 24h were all lower than those in the CMV group (P<0.05). The PaCO₂ levels in the HFOV-VG group at 6h, 12h, and 24h were all lower than those in the CMV group (P<0.05). The FiO₂ levels in the HFOV-VG group at 30 minutes, 6 hours, 12 hours, and 24 hours were all lower than those in the CMV group (P<0.05). The incidence of hypocapnia, bronchopulmonary dysplasia, and intraventricular hemorrhage in the HFOV-VG group was significantly lower than that in the CMV group (P<0.05), and there was no difference in the incidence of other complications (P>0.05), but there was a tendency to decrease in the HFOV-VG group. Conclusion: HFOV-VG demonstrated significant advantages compared with CMV in the management of ventilatory function during the recovery period of RDS in preterm infants, including shortening ventilation time, improving oxygenation, and reducing the incidence of key complications.
Functional constipation (FC) is a common functional bowel disorder, categorized under "constipation" in Traditional Chinese Medicine (TCM) theory. As a key therapeutic modality in TCM, acupuncture has long demonstrated efficacy in managing constipation. In recent years, a growing body of modern medical research has provided supporting evidence for its use. This article reviews the effects of acupuncture on brain-gut axis dysfunction, intestinal motility disorders, visceral hypersensitivity, gut microbiota imbalance, abnormal intestinal secretion, pelvic floor muscle dysfunction, and psychological factors, exploring the mechanisms and theoretical basis of acupuncture for FC.
Objective: The value of spectral computed tomography in evaluating the severity of acute pancreatitis (AP). Methods: We selected 54 patients with AP (treated between June 2024 and November 2025) and divided them into mild, moderate, and severe AP groups by employing the Revised Atlanta classification (RAC) and iodine concentration (IC) and standardized iodine concentration (NIC) values were recorded. These parameters were combined with procalcitonin, interleukin-6, haematocrit, and D-dimer levels to predict the condition of severity AP. Results: Differences in procalcitonin, interleukin-6, and hospital stay were significant (P < 0.05). IC and NIC also differed significantly between groups (P < 0.05). ROC analysis showed AUCs of 0.661, 0.748, 0.554, 0.534 for procalcitonin, interleukin-6, D-dimer, and haematocrit, respectively. IC achieved an AUC of 0.834, with an optimal cutoff of 2.7 mg/mL for diagnosing moderate-severe AP. Conclusion: Spectral CT has clinical guiding value in the diagnosis of AP.
Objective: To evaluate the dynamic changes in optic disc structure, macular blood flow perfusion, and ganglion cell complex (GCC) before and after pars plana vitrectomy (PPV) combined with silicone oil (SO) tamponade. Methods: This retrospective study enrolled 35 eyes of patients with rhegmatogenous retinal detachment (RRD) who underwent PPV combined with SO tamponade at Ningbo Eye Hospital between January 2023 and December 2025. Optical coherence tomography angiography (OCTA) examinations were performed preoperatively, during the silicone oil in situ period (3 months postoperatively), and at 3 months after silicone oil removal. Optic disc structural parameters, macular superficial and deep capillary plexus (SCP/DCP) vessel density, and GCC thickness were compared across time points. Results: Best-corrected visual acuity (BCVA) improved continuously from the preoperative period through oil removal (all P < 0.05). Intraocular pressure (IOP) increased during the oil-in period and returned to baseline after removal (P = 0.969). No statistically significant differences were observed in optic disc cup-to-disc ratio, rim area, or retinal nerve fiber layer (RNFL) thickness between the oil-in period and post-removal (all P > 0.05). DCP vessel density decreased significantly after oil removal compared to the oil-in period (37.54% vs. 33.78%, P = 0.006), while SCP showed no significant difference. GCC thickness increased significantly after oil removal compared to the oil-in period (85.28 vs. 89.60 μm, P = 0.014). Conclusions: Deep retinal microcirculation continued to decline after silicone oil removal, suggesting the presence of persistent deep retinal damage. GCC thickening may reflect correction of measurement bias during the oil-in period and partial structural recovery of ganglion cells. Clinically, vigilant IOP monitoring and evaluation of macular deep perfusion during the oil-in period are warranted, along with timely removal of silicone oil.
Objective: This study aimed to investigate the Holter ECG characteristics of patients with hypertension complicated by paroxysmal atrial fibrillation and to analyse their association with postoperative arrhythmia recurrence. Methods: A retrospective cohort study was conducted on 230 patients with hypertension complicated by paroxysmal atrial fibrillation (PAF) treated at the Electrocardiography Department of Yichang Central People's Hospital between July 2023 and December 2024. Patients were categorised into a recurrence group (n=48) and a non-recurrence group (n=182) based on postoperative recurrence status. Preoperative 24-hour Holter monitoring data were collected for all patients. Univariate analysis compared clinical characteristics between groups, whilst multivariate logistic regression identified risk factors for postoperative recurrence. Results: Univariate analysis revealed that patients in the recurrence group exhibited significantly higher values for BMI, LAD, ultra-low frequency power, low-frequency power, and heart rate deceleration capacity compared to the non-recurrence group, while high-frequency power, rMSSD, pNN50, and SDNN were significantly lower (P < 0.05). Multivariate logistic regression analysis identified heart rate deceleration capacity, SDNN, and LAD as independent risk factors for postoperative recurrence in hypertensive patients with PAF (P < 0.05). Conclusion: Quantitative parameters of Holter monitoring in patients with hypertension complicated by PAF exhibit characteristic alterations, with reductions observed in high-frequency power, rMSSD, pNN50, and SDNN. Heart rate deceleration capacity, SDNN, and LAD constitute independent risk factors for recurrence following radiofrequency ablation.
Malocclusion, a common oral health issue among adolescents, has impacts that extend beyond the physiological dimension, increasingly manifesting at the psychological level. As teenagers place growing emphasis on personal appearance and social interaction, this condition often leads to a range of psychological responses, including social withdrawal, self-identity challenges, and emotional fluctuations. To promote the harmonious physical and mental development of adolescents and to raise awareness among healthcare and educational professionals, this paper examines the mechanisms through which malocclusion affects adolescents’ social behavior, self-perception, and emotional well-being. Furthermore, it discusses feasible intervention strategies aimed at mitigating these adverse psychological effects.
Avascular necrosis of the femoral head is a common and challenging orthopedic disease. Clinically, it is divided into traumatic avascular necrosis and non-traumatic avascular necrosis. Traumatic avascular necrosis of the femoral head is often caused by hip trauma, and the risk of necrosis is positively correlated with the severity of the trauma and the delay in treatment. Here, we report the diagnosis and management of a case of complex traumatic avascular necrosis of the femoral head in a 64-year-old male, with the hope that this case can provide a reference for clinicians in dealing with similar severe post-traumatic femoral head necrosis.
