The development of sustainable synthetic methodologies has become a central objective in modern organic chemistry, driven by the need to minimize environmental impact while maintaining high efficiency and broad applicability....
Selenocyanated isocoumarins 1 could react with PhICl 2 in DMSO to give undocumented selenoisocoumestans 2 (seleno analogues of the naturally occurring isocoumestans) via an exclusive intramolecular decyanative selenocyclization.
The alkylation of structurally rigid N-heterocyclic scaffolds is a fundamental and challenging transformation in medicinal chemistry, often hindered by harsh conditions, poor sustainability, and limited substrate generality. Herein, we report...
Organosilicon compounds are versatile synthetic intermediates, yet silicon substituents are generally treated as static functional groups once installed. Herein, we report an iridium-catalyzed long-range silicon translocation enabled by C-Si bond...
A dual cobalt and photoredox catalysis intramolecular reductive coupling of enynes, enabling the efficient synthesis of vinyl-heterocyclic compounds, has been developed.
A novel aza-BCH-based allylic donor was reported for the first time. A series of methanopyrrolo[1,2- c ]imidazole derivatives were obtained through Pd-catalyzed [3 + 2] cycloadditions, further promoting the development of BCH bioactive heterocycles.
A cobalt-catalyzed controllable defluorinative alkylation of α-trifluoromethyl alkenes with alkyl bromides has been developed. By simply modulating the reaction conditions, this protocol enables the selective synthesis of either gemdifluoroalkenes or...
Photoexcited nitroarenes serve as HAT catalysts in continuous flow for aliphatic C–H functionalization, enabling Giese additions to electron-deficient alkenes and divergent radical-trapping transformations.
The unexpected fundamental influence of iodine substituent on radical addition to C=C bond was discovered. The iodine atom demonstrates strong deactivating effect on the adjacent C=C bond, which is confirmed...
A direct dehydroxylative Hiyama-type coupling between phenols and arylsilanes by using nonafluorobutanesulfonyl fluoride as activating reagent was developed. The reactions proceeded efficiently via relatively inert C-OH bond cleavage in the...
A catalyst dependent (Ag2O versus ZnBr2) protocol has been developed for the regiodivergent synthesis of aminobenzofluorenones either through in-situ generated or isolated ynone tethered with 2-alkynylanilines in good yields. DFT-calculations...
We report the first dearomative spirocyclization of BCB-tethered N -benzyl amides with sulfonyl chlorides to afford tricyclic skeletons bearing two sterically hindered spirocycles through a domino sequence.
Dimeric boron complexes bearing isoquinolyl–pyrrole ligands linked through the C3–C3′ positions of the isoquinoline rings were synthesized. Their structural rigidities and substituent effects afforded the unique fluorescence emission properties.
Acrylamides, a key class of α,β-unsaturated amides and versatile building blocks in organic synthesis. This review highlights advances over the past five years in radical annulation of acrylamides under thermal and photochemical conditions.
An efficient Selectfluor-mediated construction of structurally diverse C3-monofluorinated C2-spiroindolines has been developed.
The unified palladium-catalyzed ring-opening transformations of gem-difluorospiro[2.2]pentanes are reported. The key design is the strategic incorporation of a cyclopropane ring into the gem-difluorocyclopropane scaffold, which enables an efficient and regioselective...
Correction for ‘Stereoselective synthesis of Δ(1)-pyrroline sulfonamides via a chiral aldehyde mediated cascade reaction’ by Wei Wen et al. , Org. Chem. Front. , 2024, 11 , 156–163, https://doi.org/10.1039/D3QO01675G.
Partitioning of trivalent actinides (An(III)) from lanthanides (Ln(III)) represents a formidable task in treating radioactive nuclear wastes. Most traditional extractants suffer from limitations such as insufficient extractability and selectivity in...
The oral bioavailability of Peramivir is limited by the coexistence of highly polar guanidinium and carboxyl groups. While previous strategies have focused on modifying a single functional group, we herein...
A dienyl isothiocyanate Michael acceptor platform enables nucleophile-controlled divergent synthesis of N- and N,S-heterocycles from a common precursor.
