A protein (F1-a) was isolated and purified from sheep small intestine using column chromatography over Sephadex G-25, DEAE-650M, and HW-55F. The protein content was 55.28
Experimental data for the reactions of natural β-ionone with phosphorus-containing regents, i.e., methyl dichlorophosphite and P–H-phosphonium salts were presented. The reaction of β-ionone with methyl dichlorophosphite formed 1,2-oxaphospholene with an unsaturated cyclic moiety in the 3-position. Hydrolysis of the obtained 1,2-oxaphospholene opened the oxaphospholene ring to give 1-cycloalkyl-3-oxobutylphosphonic acid. The P–H-phosphonium salts (using triarylphosphonium triflates as examples) were shown to add ionone to the multiple bond in the β-position to the carbonyl group to form 1-cycloalkyl-3-oxobutylphosphonium salts that demonstrated high cytotoxicity against human cancer cell lines with IC50 1.1–32.4 μM and antibacterial activity against Gram-positive bacteria.
A new 12-methylene biflavonoid, named 3′′,3′′′-dimethoxy-4′′/4′′′-dihydroxy-11/11′-dicarboxydibenzofuran-12-methylene biflavonoid (1), and two known 12-methylene biflavonoid derivatives (2 and 3) were isolated from Citrus medica L. var. sarcodactylis Swingle to our knowledge for the first time. Their structures were elucidated by extensive spectral data and related references. Among them, compound 1 (10 μM) exhibited moderate hepatoprotective activities with cell-survival rates of 69.68 ± 0.93
Runners of Rhododendron adamsii Rehder (Ericaceae) afforded 18 flavonoids, among which were glycosides of myricetin, quercetin, dihydromyricetin, and dihydroquercetin, including the two new compounds 1 and 2. The new flavonoids were myricetin 3-O-β-D-glucuronopyranoside-3′-O-β-D-glucopyranoside (adamsoside I, 1) and myricetin 3-O-β-D-(6′′-O-galloyl)-glucopyranoside-3′-O-β-D-glucopyranoside (adamsoside II, 2). Compounds 1 and 2 possessed antiradical activity.
The new flavone glycoside datiscetinoside (datiscetin-2′-O-β-D-glucopyranoside) (1) and ten known aglycon and glycosylated flavonoids (2–11) were isolated from the aerial part of Datisca cannabina (Datiscaceae). The chemical structures of the isolated compounds were proved and identified using IR, UV, 1H and 13C NMR spectra and COSY, HSQC, and HMBC experiments. The antiradical activity of total flavonoids obtained from the EtOAc fraction of the aqueous EtOH extract of the aerial part of D. cannabina was investigated.
In this study, 14 compounds, including a novel pyrrole alkaloid glycoside (6), were isolated from Moringa oleifera roots, and their structures were determined using spectroscopic analyses. This is to our knowledge the first report of compounds 1–5, 7, and 10 isolated from M. oleifera roots, and compounds 8, 9, and 11–14 from the plant. Our findings highlight the chemical diversity of M. oleifera and provide novel insights into its chemical profile.
A new apocarotenoid glucoside, syndulcific acid (1) as well as (+)-vomifoliol (2), (+)-dehydrovomifoliol (3), 4-acetonyl-3,5-dimethoxy-p-quinol (4), protocatechuic alcohol (5), protocatechuic acid (6), malic acid (7), and 3-hydroxypropionic acid (8), were isolated from the fruits of Synsepalum dulcificum (Sapotaceae). The structure of the new apocarotenoid glucoside was elucidated by chemical and physical evidence.
