Background and Aims: This study aims at determining the demographic profile and extra-intestinal manifestations of Ulcerative Colitis in the Nepalese patients treated in a tertiary referral centre. Methods : The study was conducted between February 1, 2014 and January 31, 2015 at the Department of Gastroenterology Tribhuvan University Teaching Hospital, Kathmandu, Nepal. The clinical and epidemiologic data from patients diagnosed to have Ulcerative Colitis were obtained and analysed. Results : During the study period, 60 patients were identified as having ulcerative colitis. Mean age at diagnosis was 34.6 years. The mean duration of illness at diagnosis was 3.7 years. Extra-intestinal manifestations (EIM) were seen in 16.6% of the patients. Sacroilitis was the most common EIM seen in11.6% followed by peripheral arthritis in 6.6% of the patients. Episcleritis, Primary Sclerosing Cholangitis and Erythema Nodosum were seen only in 1.6% each. At the time of presentation, 38.3% (n=23) had proctosigmoiditis , 50% (n=30) left sided colitis and pancolitis was seen in 11.7% (n=7).53.3% patients had mild disease, 38.3% and 8.3 % presented with moderate to severe disease respectively. Conclusion : Peak age of onset for UC in the study was third and fourth decade which was similar to the various studies from Asia and West. Musculoskeletal manifestation was the most common extra- intestinal manifestation of UC in Nepalese population. As Nepal is perhaps the most diverse country in terms of ethnicity, cultural variation, socio-economic status and health care facilities, a comprehensive nationwide data bank involving ethnicity and geographical variation is needed for a better definition of the disease characteristics. Journal of Advances in Internal Medicine 2015;04(01):1-5.
Chapter 4 The Molecular Genetics of Lung Cancer David S. Shames, David S. ShamesSearch for more papers by this authorMitsuo Sato, Mitsuo SatoSearch for more papers by this authorJohn D. Minna, John D. MinnaSearch for more papers by this author David S. Shames, David S. ShamesSearch for more papers by this authorMitsuo Sato, Mitsuo SatoSearch for more papers by this authorJohn D. Minna, John D. MinnaSearch for more papers by this author Book Editor(s):Jack A. Roth MD, F.A.C.S., Jack A. Roth MD, F.A.C.S. Professor and Bud Johnson Clinical Distinguished Chair, Department of Thoracic and Cardiovascular Surgery, Professor of Molecular and Cellular Oncology, Director, W.M. Keck Center for Innovative Cancer Therapies, Chief, Section of Thoracic Molecular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USASearch for more papers by this authorJames D. Cox MD, James D. Cox MD Professor and Head, Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USASearch for more papers by this authorWaun Ki Hong MD, D.M.Sc. (Hon.), Waun Ki Hong MD, D.M.Sc. (Hon.) American Cancer Society Professor, Samsung Distinguished University Chair in Cancer Medicine, Professor and Head, Division of Cancer Medicine Professor, Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USASearch for more papers by this author First published: 01 January 2008 https://doi.org/10.1002/9780470696330.ch4Citations: 3 AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onFacebookTwitterLinked InRedditWechat Summary This chapter contains section titled: A brief History of Cancer Genetics Overview of Lung Cancer Etiology, Incidence, and Treatment Molecular Genetics of Lung Cancer Preneoplasia and the Early Detection of Lung Cancer Epigenetic Basis of Lung Cancer—DNA Methylation and Tumor Suppressor Gene Inactivation Tumor Suppressor Genes Oncogenes and the Pathways They Regulate Receptor Tyrosine Kinases RAS/RAF/MEK/ERK Pathway References Citing Literature Lung Cancer, Third Edition RelatedInformation
