We present a rare case of concurrent multiple myeloma and gastrointestinal (GI) amyloidosis with jejunal and duodenal involvement masquerading as chronic gastritis with poor response to treatment in a 65-year-old woman. Oesophagogastroduodenoscopy and biopsy identified amyloid deposition while serum protein electrophoresis revealed monoclonal gammopathy. Subsequent bone marrow aspiration confirmed the diagnosis of multiple myeloma with clonal plasma cells of 45%. This case highlights the rare presentation of multiple myeloma and GI amyloidosis with jejunal and duodenal involvement, masquerading as chronic gastritis with poor treatment response.
