Cancer-related fatigue (CRF) and impaired health-related quality of life (HRQoL) are prevalent and clinically important concerns in patients with breast cancer undergoing chemotherapy. Although exercise is recommended during cancer treatment, the magnitude and certainty of the effects attributable specifically to aerobic exercise delivered during chemotherapy remain unclear, as does potential variation across exercise-program characteristics. This review aimed to quantify the effects of aerobic exercise on CRF and HRQoL in this setting and to explore potential variation across exercise-program characteristics. A comprehensive search was conducted across PubMed, Embase, Web of Science, the Cochrane Library, and EBSCOhost from inception to February 2026. Randomized controlled trials of aerobic exercise during chemotherapy in adult patients with breast cancer were included. A meta-analysis was conducted to quantify standardized mean differences (SMDs) and 95
Tumor-draining lymph nodes (TDLNs) play a critical role in mediating responses to immune checkpoint inhibitors (ICI). However, the impact of extensive TDLN yield on survival outcomes in colorectal cancer (CRC) patients undergoing neoadjuvant immunotherapy remains unclear. This study aims to investigate the influence of the number of TDLNs dissected on recurrence-free survival (RFS) in CRC patients treated with neoadjuvant immunotherapy, with a particular focus on elucidating the role of TDLNs in immune responses to ICI. We retrospectively analyzed data from 195 CRC patients who underwent curative surgery following neoadjuvant ICI therapy. The study assessed the number of lymph node yield and its association with postoperative recurrence. Single-cell RNA sequencing and T-cell receptor sequencing were conducted on tumor, peripheral blood, and TDLN samples from CRC patients. Our findings revealed that higher lymph node yield (≥ 20 nodes) was associated with poorer RFS in TNdiss CRC patients treated with ICI. Single-cell analysis showed ICI‑treated patients exhibited a higher frequency of clonally shared CD8 + Tem cells between TDLNs and tumor tissues, suggesting immunological connectivity between these compartments. A higher lymph node yield was associated with poorer survival outcomes in CRC patients receiving neoadjuvant immunotherapy. However, the mechanisms underlying this association remain unclear and warrant further investigation.
Osimertinib is the standard first-line therapy for epidermal growth factor receptor (EGFR)-mutated advanced non-small cell lung cancer (NSCLC), but outcomes remain heterogeneous. This meta-analysis evaluated baseline clinical and molecular prognostic factors associated with poorer outcomes in this setting. PubMed, Embase, Web of Science, Scopus, and the Cochrane Library were searched through 20 May 2026. Eligible studies included patients with EGFR-mutated advanced, recurrent, or metastatic NSCLC receiving first-line osimertinib with extractable prognostic data. The primary outcome was progression-free survival or real-world progression-free survival (PFS/rwPFS); overall survival or real-world overall survival (OS/rwOS) was secondary. Hazard ratios (HRs) were pooled using random-effects models. Eighteen studies involving 4,070 first-line osimertinib-treated patients were included. TP53 mutation was associated with shorter PFS/rwPFS (HR 1.65, 95
Preoperative,image-only stratification of breast cancer prognostic factors and molecular subtypes remains a clinically important objective. Most existing reports have analysed dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imaging (DWI) in separate cohorts, used heterogeneous protocols, and lacked formal multivariable modelling. The aim of the study was to investigate, in a single large Chinese cohort, the correlation between quantitative DCE-MRI parameters (Ktrans, Kep, Ve), the apparent diffusion coefficient (ADC) and breast-cancer prognostic factors (ER, PR, HER-2, Ki-67) and molecular subtypes; and to develop a multivariable logistic regression model for the preoperative identification of triple-negative breast cancer (TNBC). A retrospective analysis was conducted on 746 patients with breast cancer surgically and pathologically confirmed at our hospital between January 2016 and January 2019. All patients underwent preoperative 3.0T DCE-MRI and DWI; DWI was performed prior to contrast injection. Quantitative DCE-MRI parameters (Ktrans, Kep, Ve) were derived using the extended Tofts model on a vendor-neutral platform (Tissue 4D, Siemens). ROI placement reproducibility was quantified by intraclass correlation coefficients (ICCs) in 100 lesions independently re-measured by two readers and re-measured 4 weeks later by the senior reader. Distributions were assessed by Shapiro–Wilk and Levene's tests. Bonferroni correction was applied to the 16 Spearman correlation tests (corrected α = 0.003). AUCs were reported with 95
