Vaccination has made the greatest contribution to global health of any human intervention apart from the introduction of clean water and sanitation Despite the successes, approximately 6 6 million children still die each year and about a half of these deaths could be prevented by vaccination The COVID-19 pandemic has pushed the vaccine industry right to the forefront The expectation has never been this high to come up with innovative solutions to fight this terrible disease and to develop an effective vaccine in an unprecedented time frame Over the last several decades there has been a significant evolution in breakthroughs in bioprocess technologies to support vaccine development The advances in these technologies have greatly benefited vaccine development and manufacturing to achieve consistent product purity and quality, in a timely and cost- effective manner This article reviews the constraints and complexities in the vaccine industry, specifically in vaccine product development and manufacture;and describes the current trends in bioprocess development and manufacturing innovation and technologies to overcome these challenges, with an outlook into the future © 2021 TeknoScienze All rights reserved
