Fibrin glue (fibrin sealant) is a biologic adhesive that reproduces the final phase of the coagulation cascade by combining fibrinogen and thrombin to form a stable fibrin matrix. In dentistry and periodontology, its role has expanded from local hemostasis to wound sealing, tissue adhesion, graft stabilization, and regenerative support. This narrative review summarizes the biologic rationale, clinical applications, comparative evidence, limitations, and future perspectives of fibrin glue in modern dental practice. Fibrin glue has demonstrated value in dental extractions, particularly in patients with increased bleeding risk, as well as in periodontal flap closure, mucogingival surgery, bone grafting, and guided bone regeneration (GBR). The emerging Fibrinogen-Induced Regeneration Sealing Technique (F.I.R.S.T.) further illustrates its regenerative potential by using fibrin sealant to stabilize graft particles and barrier membranes during GBR procedures. Despite these advantages, current evidence remains limited by small sample sizes, heterogeneous methodologies, short follow-up periods, and inconsistent outcome reporting. Therefore, fibrin glue should presently be considered a selective adjunct rather than a universal replacement for sutures or mechanical fixation. Future studies should focus on standardized protocols, long-term clinical and radiographic outcomes, patient-reported measures, comparative effectiveness, and cost-effectiveness analyses to better define the role of fibrin glue in dental and periodontal regeneration.
Dental and orthopedic implants are long-term medical devices for which regulatory oversight, quality management, clinical evaluation, and post-market surveillance are important. However, the present pilot study did not collect patient-level clinical outcome or device-level survival data; therefore, it does not directly establish differences in clinical performance between domestically manufactured and imported implants. A pilot mixed-methods study was conducted using a structured questionnaire and semi-structured interviews. The questionnaire underwent item generation, expert content validation, face-validity assessment, pilot testing, exploratory analysis, and internal-consistency assessment. The pilot survey included seven respondents: four clinicians (two dental surgeons and two orthopedic surgeons) and three regulatory experts. Descriptive statistics were used for Likert-scale responses, while thematic analysis was used for interview data. The study was conducted from January 2025 to June 2025 at Sharda University and affiliated professional networks in northern India. A 70.0
Inflammation serves as the primary driver of periodontal pathogenesis, yet it remains frequently neglected despite its profound impact on systemic health. Characterized by dysbiotic microbial accumulation, the disease triggers a persistent host immune response that inadvertently facilitates destruction of periodontium. Upregulated inflammatory markers, specially C-reactive protein and pro-inflammatory cytokines, accelerate proteolytic enzyme activity and collagen degradation, leading to irreversible alveolar bone loss. Conventional diagnostic tools offer only limited, static insights into the disease state, and often fail to provide a dynamic or patient-specific assessment. Consequently, there is a growing need for more accurate and personalized strategies in periodontal healthcare. This review explores the growing transition towards precision medicine paradigm that integrates molecular diagnosis with nanotechnology. Biomarkers referred to as the biological indicators are detectable in fluids like saliva, gingival crevicular fluid (GCF), and blood which can reflect early disease activity and inflammatory processes. These biomarkers can be implemented for the “smart” nano-delivery systems ensuring site-specific, sustained release of therapeutics to optimize therapeutic response. Engineered nanomaterials, including nanoparticles, nanofibers, biosensors, and dendrimer-based systems can target diseased areas directly while ensuring sustained release of medication, and promoting healing at the cellular level. The convergence of nanotechnology and biomarker research holds the potential for the development of personalised treatment protocols, facilitating a shift from generalized care for periodontal disease management.
Orthodontic miniscrews are widely used as temporary anchorage devices, yet failure rates ranging from 10 to 20 https://doi.org/10.17605/OSF.IO/M5CR2 ). Risk of bias was assessed using the QUIN tool for in vitro studies. In total, 639 records were screened following an updated search through may 2026, of which 17 in vitro studies were included. Nanoparticles assessed included zinc oxide, silver, titanium dioxide, hydroxyapatite, chlorhexidine hexametaphosphate, chitosan, and composite formulations.). Antimicrobial efficacy was assessed using inhibition zone diameter, colony-forming unit (CFU) counts, and percentage bacterial reduction against key oral pathogens including S. mutans, S. aureus, and P. gingivalis. Surface parameters evaluated were roughness, wettability, morphology (via SEM/TEM), and elemental composition (via XRD, XPS, EDS, and FTIR. The QUIN tool evaluation revealed that most studies (80
This systematic review aimed to evaluate different approaches for palatal donor areas of gingival grafts in the reduction of postoperative pain and to categorize protection/action methods for these donor sites. The review was conducted in accordance with PRISMA 2020; Cochrane handbook guidelines and registered in PROSPERO (CRD42023454193). Databases PubMed, Embase, Scopus, Web of Science and Cochrane Library were searched. Randomized controlled clinical trials (RCTs) comprising free gingival grafts (FGG) or de-epithelialized connective-tissue grafts (dSCTG) with data about postoperative pain (Visual analogue scale-VAS) were included. Risk of bias of included RCTs was assessed using RoB 2. A narrative and descriptive synthesis of data was performed. A total of 85 articles were initially identified for title screening, but 33 articles were selected for full-text reading. 28 studies met inclusion criteria for qualitative analysis (n=1187). Thirteen studies (46.4
