Introduction: Helicobacter pylori (H. pylori) is a bacterium responsible for inflammation of the gastric mucosa. This bacterium causes chronic gastritis in more than 50% of the world’s population and, in about 10 to 15% of cases, can lead to gastric adenocarcinoma, gastroduodenal ulcers, and MALT lymphoma. Notably, H. pylori infection is more prevalent in less developed countries due to poor hygiene, lack of information, and overcrowding. Objective: This study aimed to evaluate the level of knowledge about Helicobacter pylori infection in patients of the Gastroenterology Service from a hospital in Atein 2023. Materials and Methods: An observational, descriptive, cross-sectional, prospective study was conducted at the hospital in Atein Lima, involving 352 adult patients who attended the gastroenterology outpatient clinic between October and December 2023. A validated survey consisting of 20 questions covering sociodemographic data and knowledge about H. pylori infection was used. Statistical analysis was performed using SPSS v.25, using descriptive measures, including frequencies and percentages. Results: The study consisted of 352 patients aged 35 to 60 years, predominantly women. It was identified that 42.6% had a low level of knowledge about H. pylori. Most had low knowledge about conceptual definitions (63.4%) and modes of infection (52.0%). Regarding complications, 44.88% were aware of the relationship with gastric cancer. Conclusion: This study highlights the need to implement educational and awareness strategies to improve knowledge about H. pylori infection among patients. More research is warranted to understand the barriers to greater knowledge and develop effective interventions to overcome them.
Background: Primary pulmonary myxoid sarcoma is a very rare tumor, with less than 25 cases being described in the literature. When found in the bronchial tree, an R0 resection with post-operative follow-up is sufficient for curative treatment. We present a case of primary pulmonary myxoid sarcoma in a middle-aged man with an associated review of the literature to highlight this rare tumor. Case presentation: A 62-year-old man with a 40-pack-year smoking history presented to the thoracic surgery clinic for evaluation of a suspicious lung nodule. Pre-operative testing revealed a spiculated mass in the left upper lobe and the biopsy was non-diagnostic. The patient was taken for left upper lobectomy tri-segmentectomy with mediastinal lymph node dissection. Final pathology of the nodule revealed primary pulmonary myxoid sarcoma with an Ewing sarcoma breakpoint region 1 on chromosome 22 with activating transcription factor 1 (EWSR-ATF1) fusion transcript consistent with the diagnosis. Conclusion: Primary pulmonary myxoid sarcoma is an exceedingly rare sarcoma of the lung with less than 25 reported cases in the literature. This case report highlights our experience treating primary pulmonary myxoid sarcoma in a middle-aged man, and a review of current treatment recommendations in the available published literature.
Metastasis is one of the most challenging problems in cancer diagnosis and treatment, as causal factors have yet to be fully disentangled. Prediction of the metastatic status of breast cancer is important for informing treatment protocols and reducing mortality. However, the systems biology behind metastasis is complex and driven by a variety of interacting factors. Furthermore, the prediction of cancer metastasis is a challenging task due to the variation in parameters and conditions specific to individual patients and mutation subtypes. In this paper, we apply tree-based machine learning algorithms for gene expression data analysis in the estimation of metastatic potentials within a group of 490 breast cancer patients. Tree-based machine learning algorithms including decision trees, gradient boosting, and extremely randomized trees are used to assess the variable importance of different genes in breast cancer metastasis. ighly accurate values were obtained from all three algorithms, with the gradient boosting method having the highest accuracy at 0.8901. The most significant ten genetic variables and fifteen gene functions in metastatic progression were identified. Respective importance scores and biological functions were also cataloged. Key genes in metastatic breast cancer progression include but are not limited to CD8, PB1, and THP-1.
Childhood hydrocephalus is a common disorder in which too much Cerebrospinal Fluid (CSF) accumulates within the ventricles (fluid-containing spaces) of the brain and is usually the-ted by cerebrospinal fluid shunting using a ventriculoperitoneal or ventriculoarterial shunts. The most common condition is hydrocephalus, where there is dilation of the ventricular system due to an obstruction in the flow of CSF or decreased absorption of CSF by the arachnoid villi. Shunting of CSF is the treatment of choice in childhood hydrocephalus.
Pediatric perioperative mortality is a measure of the quality and safety of surgical care in children. The aim of study was to evaluate the incidence, etiology and pattern of pediatric perioperative mortality (within 24 hours and within 30 days post-surgery) in a teaching hospital in Enugu, Nigeria.
