Abstract Acute pityriasis lichenoides et varioliformis acuta (PLEVA), also known as Mucha-Habermann disease, is a self-limiting inflammatory dermatosis characterised by an abrupt onset of polymorphic lesions, including scaly erythematous papules, vesicles, haemorrhagic necrosis and ulceration, often leaving varioliform scars. This case series reports four male patients with PLEVA who achieved significant improvement after oral apremilast therapy.
Abstract Background: Chronic inducible urticaria (CIndU) is rare in children, with limited data available about its clinical features and prognostic factors. Aims: This study aimed to evaluate the clinical characteristics, subtype distribution, and prognosis of paediatric CIndU in a Turkish cohort. Methods: A retrospective analysis was conducted on 60 paediatric patients diagnosed with CIndU between 2019 and 2020 at a tertiary hospital. Data were collected on demographics, subtypes, comorbidities, treatments, and outcomes. Multivariate logistic regression was used to identify factors associated with non-remission. Statistical analyses included t-tests, Mann–Whitney U tests, and Kruskal–Wallis tests ( P < 0.05). Results: Symptomatic dermographism was the most common subtype (54%), followed by cold urticaria and cholinergic urticaria (13% each). Females predominated (55%), with symptomatic dermographism significantly more common in females (71.9%, P < 0.05). Anaphylaxis occurred in three patients (5%). During follow-up (n = 51), 31.4% achieved remission, 39.2% had reduced medication needs, and 29.4% required unchanged doses. Symptomatic dermographism had the best prognosis (34.6% remission). Logistic regression showed that atopy significantly increased the likelihood of non-remission (adjusted odds ratio = 4.622, 95% confidence interval: 1.119–19.078, P = 0.035), while age, gender, and subtype were not significant ( P > 0.05). Conclusion: Paediatric CIndU is heterogeneous, with symptomatic dermographism being the most common and least severe subtype. Atopy is a significant predictor of persistent disease, contrasting with some research in the literature but supported by recent studies. Larger studies are needed to validate these findings.
Abstract Dowling-Degos disease (DDD) is an uncommon autosomal dominant disorder, typically identified by the development of acquired reticular hyperpigmentation in areas of skin folds. DDD is a genodermatosis, with fewer than 100 cases recorded in medical literature. To our knowledge, there have been only two documented occurrences of DDD reported in individuals from Saudi Arabia. We present a unique case involving a Saudi patient displaying isolated hyperpigmented macules localised in the axillae, groins, and lower abdomen, histopathologically confirmed to be Dowling-Degos disease. This case is accompanied by a review of reported instances in Saudi Arabia.
