Introduction: Diabetes is regarded as 21st century’s epidemic. To prevent complications, apart from life style modification pharmacotherapy is required to control blood sugar. Even though many oral antidiabetic drugs are available, satisfactory/target glycaemic control is not achieved. Cost of drug therapy is an important factor influencing compliance with treatment, particularly chronic diseases. So, need for periodic evaluation of prescription of diabetic patients. Aims and objective: To analyse pattern of antidiabetic drug prescriptions and percentage cost variation of prescribed antidiabetic drugs. Methods: This was a cross sectional observational study conducted among type 2 diabetes patients aged>12 yrs (either gender) at Out Patient Department (OPD) of private diabetes clinic during 2018-2019. Juvenile diabetes, gestational diabetes, indoor patients were excluded from the study. Patients were interviewed and details were filled up in case record form. Socio-demographic data, prescription pattern, percentage cost variation and cost ratio were analyzed. Result: Total 349 patients were enrolled with mean age 53 ± 12 years. Average no. of antidiabetic drugs per prescription was 3.34. Majority (96.56%) patients were prescribed at least one Fixed Dose Combination (FDC). Most common FDC was (97.99%) with biguanides and sulfonylureas. FDC with Metformin (500 mg) and glimepiride (2 mg) had maximum percentage cost variation (712.20) and very high cost ratio (8.12). Satisfactory glycemic levels were achieved in 58.45% patients. Conclusion: Polypharmacy, overuse of FDC’S with vast percentage cost variation and high cost ratio was observed. Need to pay attention towards diabetic education training, rational treatment approach and pricing control of medicine by regulatory agency
The occurrence of contaminations because of Expanded range β-Lactamase (ESBL) – creating Escherichia coli has been expanded significantly as of late. Treatment is troublesome in view of continuous multidrug opposition. To distinguish the affectability of normally utilized anti-infection agents, strains were disengaged from youthful grown-up female patients in a govt. clinical school medical clinic in Bangladesh. The examples were read for antimicrobial affectability against nine ordinarily utilized anti-microbial specifically ampicillin. In general, 72% of the strains were Multi Drug Safe (MDR) impervious to at least two medications. Among 36 strains, 14 segregates were at first discovered to be safe against third era cephalosporin, ceftriaxone. This finding plainly shows the significance of utilizing more current wide range anti-infection agents to treat this sort of contamination. These catalysts are equipped for hydrolyzing wide range cephalosporins and monobactams however idle against cephamycins and imipenem. So these new more extensive classes of anti-microbial in the treatment of UTIs ought to be presented.
An inert hydrophobic buoyant coated core was developed as Floating Drug Delivery System (FDDS) for sustained release of cisapride using direct compression technology. Core contained low density, porous ethyl cellulose, which was coated with an impermeable, insoluble hydrophobic coating polymer such as rosin. It was further seal coated with low viscosity hydroxypropyl methyl cellulose (HPMC E15) to minimize moisture permeation and better adhesion with an outer drug layer. It was found that stable buoyant core was sufficient to float.
The present study was an attempt to formulate and appraise enteric coated tablets for esomeprazole metal rehydrate. Altogether completely different core tablets were prepared and formulation was elect for any enteric coating, supported the disintegration time. Seal coating was applied to comprehend three-D weight gain using ovary. Enteric coating was distributed using altogether completely different polymers like Eudragit, building block pro-ply methylcellulose phthalate, ester phthalate to comprehend 5-hitter weight gain.
Peptic ulcer infection is the term used to depict a heterogeneous gathering of condition where there is ulceration of the throat, stomach or duodenum. This is obviously connected with some neighborhood aggravation of physiological harmony. Peptic ulcer illness is quite possibly the most widely recognized gastrointestinal problems, which causes a high pace of dismalness especially for the number of inhabitants in no industrialized nations.
