Excessive consumption of red and processed meat has been associated with a higher risk of developing colorectal cancer. There are many attempts to explain the risk of colorectal cancer associated with the consumption of red and processed meat: The temperature cooking of meat such as grilling and smoking contribute to the formation of mutagenic compounds including heterocyclic amines and polycyclic aromatic hydrocarbons. Heme iron in red meat is involved in the formation of N-nitroso compounds and lipid peroxidation products in the digestive tract. Fatty red meat is involved in the production of secondary bile acids by the bacteria of the gut microbiota. Many of the products formed are genotoxic and can cause DNA damage and initiate carcinogenesis of colorectal cancer. Various mechanisms contributing to their genotoxic role have been established in human and animal studies. In addition, there is increasing evidence that compounds formed from red and processed meat interact with the gut microbiota in colorectal cancer pathways. Although several early studies in animals and humans suggest a direct causal role of the gut microbiota in the development of colorectal cancer, the links between diet, gut microbiota, and colonic carcinogenesis are largely associations rather than proven causal relationships. Various biological mechanisms, including inflammation and oxidative stress can lead to DNA damage, gut dysbiosis, and therefore increase the risk of colorectal cancer. Dysbiosis of the gut microbiota may increase the risk of colorectal cancer through dietary component promotion of colonic carcinogenesis. In this paper, we review and update current knowledge about the relationships between red meat consumption, gut microbiota, and colorectal cancer.
Prestigious Award for Young Research’s at Tissue Engineering 2020 - Exploring new Ideas in regenerative medicine to treat degenerative diseases Tissue Engineering 2020 Conference Committee is pleased to announce “on13th International Conference on Tissue Engineering and Regenerative Medicine” March 18 -19, 2020 in Paris, France by focus on the theme: “New Frontiers and Innovations in Stem Cells and Biomaterials”. Tissue Engineering 2020 developments are maintaining their momentum. Tissue Engineering 2020 Conference program delves into strategic discussions in the field of Stem Cell and Biomaterials
3rd Global Summit on Oncology and Cancer was sorted out on May 6-7, 2019, Radisson Hotel Narita, Tokyo, Japan. Global cancer congress has gotten a prosperous reaction from everywhere throughout the world. This has been sorted out with the point of Cancer Prevention, Diagnosis, and Treatment of sicknesses of the Organ-related Cancers and its imaginative techniques.
