Background: Percutaneous kidney biopsy is the primary diagnostic tool used in kidney diseases. In general, it is a low-risk procedure in a majority of the patients, however, complications do occur and the most common complications are pain abdomen and bleeding which may be microscopic or macroscopic hematuria or perirenal hematoma. We aim to assess all the biopsies performed by following the patients postprocedure. Materials and Methods: All patients were evaluated before renal biopsy with prebiopsy investigations like Hemoglobin percentage, platelet count, and other test for coagulation. Following which patients underwent ultrasound guided renal biopsy. post renal biopsy they were followed clinically for pulse rate , blood pressure and laboratory monitoring by repeat hemoglobin levels, and by ultrasound scan for any hematoma and visible hematuria. The results were compared to prebiopsy values and tabulated and difference in values were assessed. Results: We enrolled 88 patients in our study done over 3 years; out of 88 patients enrolled, we found that 58% of the patients were male and 42% were female; following biopsy, pain abdomen was the most common symptom reported in 50% of the patients, followed by hematuria in 33% of the patients. Out of 88 patients, 57 patients (64%) had a decrease in Hb from their prebiopsy levels, but the range was 0.1g/dl-3.4g/dl drop with a mean value of 0.932 ± 0.819 g%. Seventeen patients (19.3%) developed hematoma on day 1 following biopsy with a size ranging from 1 cc to 25 cc hematoma with a mean size of 3 cc, which decreased in size on follow-up scans to 3 (3.4%) patients on day 3 having persistent hematoma with a Median size of 4cc on day 3. The odds ratio (O.R) for developing hematoma following kidney biopsy was assessed in different groups. It was found that those patients who had their baseline serum creatinine >3mg/dl had O R of 1.66 95% C.I, [0.53-5.07]. And those patients whose systolic blood pressure was >160 mm of Hg had an Odds Ratio of developing hematoma of O.R 2.77 95% C.I [0.43-11.08]. Conclusion: Renal biopsy is a relatively safe procedure with some morbidity and occasional mortality if performed by screening of patients thoroughly for bleeding parameters, and patients may require monitoring postprocedure by repeated ultrasound scans if needed. Moreover, bleeding in many patients is clinically insignificant rarely requiring any transfusion postprocedure. Moreover, patients with high prebiopsy creatinine have some risk of bleeding than other patients with normal kidney function.
Background Dialysis adequacy is an important and effective factor in reducing mortality and morbidity among patients with end-stage kidney disease. This study aims to assess the current clinical situation of hemodialysis (HD) patients, to monitor the established quality-of-care indicators, and to identify the unachieved quality-of-care goals. Patients and methods This is an observational study in which all patients underwent chronic HD program (>1 year) at the nephrology center in Benghazi, Libya. It was conducted between January and June 2018. Mean levels were collected for the following indicators: hemoglobin, dialysis dose, serum calcium and phosphorus, parathyroid hormone, systolic and diastolic blood pressure, interdialytic hypotension, and vascular access. Results A total of 292 dialysis patients were reviewed and followed over a 6-month period. Overall, 170 (58.2%) were males and 122 (41.8%) were females. Mean age was 51.1±14 years. Hypertension was the most common cause of end-stage kidney disease in 76 (26.0%) patients followed by diabetes mellitus in 32 (11.0%) patients. Our patients failed to achieve adequate HD, as laboratory value results were as follows: mean hemoglobin level less than 10 g/dl in 61% of patients, serum Ca+2 was less than 8.4 mg/dl in 48.6%, serum PhO4 was more than 5.5 mg/dl in 50%, and serum parathyroid hormone was more than 300 ng/dl in 60.3%. Conclusion Dialysis insufficiency was seen in a significant percent of patients in this study. More extensive research studies for finding the causes of low dialysis quality are suggested.
Background: Oxidative stress is one of the main causes of cataract and can be induced by selenite administration in rats. In experimentally induced cataract, sodium selenite may affect the reproductive system in young animals because of induction of oxidation condition. Methods: Sixty-four male 8-day-old Sprague Dawley rats were divided into five groups: control; pomegranate peel extract (PPE) 500 mg/kg; sodium selenite 30 μmol/kg; PPE and sodium selenite simultaneously on day 8; and PPE on day 6 and sodium selenite on day 8. A histopathological study was performed after 4 weeks. Results: Cataract was induced in all treated rats with selenite sodium. The volume and weight of the right and left testicles, the weight of the right and left epididymis, and the weight of the Cowper's gland, seminal vesicles, and prostate were significantly different between the sodium selenite group and other groups. On the other hand, the histopathological examination revealed tissue damage, interstitial edema, and the degeneration of spermatogenic cells in seminiferous tubules in the group which had received sodium selenite. There was a significant difference in all of the morphometric parameters of the genital system in rats, except the weight of the prostate between the PPE group and PPE and sodium selenite simultaneously group. Conclusion: The consumption of PPE improves the testis pathology indices in immature male rats with cataract induced by sodium selenite.
Leydig cell tumors form 1%-3% of all testicular tumors. We report a case of incidental Leydig cell tumor in a case of detorted testis.
