Basal cell carcinoma is the most common malignancy of skin with least mortality and high morbidity index in humans. With greater incidence in aging population and widespread sun exposure cases in India, this malignancy is associated with extremely low metastatic potential with severe disfigurement and distortion. About 25%- 30% of cases occur on various anatomical parts of the nose with rapid recurrence rate after surgical intervention. The pathogenesis involves a complex interplay between environmental factors, patients' specific characteristics and genetics, exemplified with various modifiable & non-modifiable risk components. We report an advance deteriorated case of BCC of nose presenting with a typical rodent ulcer behavior that was treated under local anesthesia using Nasolabial flap (NFL) reconstructive surgical approach to close the defect. Although the case highlights common characteristic features that have already been documented in previous literature, we have focused on investigating the efficiency of NLF surgical intervention under local anesthesia considering a single patient as a sole unit of observation, thereby making this case as "N of 1 type" of educational case report. Additionally, we have applied the customized PSQ scale III (short form) developed by Grant N Marshall & Ron D Hays to assess the patient satisfaction level so as to bridge the gap of most neglected area in health care centers making this case more unique & exceptional.
Fibro - osseous lesions are characterized by replacement of normal bone by fibrous tissue containing a newly formed mineralized product. It includes fibrous dysplasia, cemento osseous dysplasia and ossifying fibroma. The authors present a case report of a 40-year-old female patient who experienced dull pain and bone exposure in the lower right posterior region of the mandible. Radiographic examination revealed multiple mixed radiolucent and radiopaque lesions in the mandible. Special staining with Modified Gallego's stain highlighted cementum-like deposits in red. Based on the clinical and radiological findings, the patient was advised to undergo surgical resection. This case report discusses the pathogenesis, histopathological features, and differential diagnosis of the lesion.
Background: The immune system is a highly controlled network that enables the emergence of antigen-specific defensive mechanisms against outside antigens and tolerance to self-antigens. Objective: Isolation of CD3+T cells from PBMCs of healthy individuals and analyse T cell proliferation, secretion of IFNgamma, IL-2, IL-4 and IL-17, and expression of Tbet, GATA-3 and RORgammaT post activated and culture of CD3+ T cells Material And Method: The study was conducted in the department of oral pathology and microbiology, Dr. D Y Patil Dental College and Hospital Pimpri Pune. Blood samples were collected from 5 healthy individuals. The study parameters included isolation of peripheral blood mononuclear cells. Activation of CD3+ T cells and analysis of T cell proliferation, secretion of cytokines and gene expression. The study was approved by the college ethics committee. Result: 1.68% proliferation CD4+CD69+ t cells are seen without activation and with activation 30.78% proliferation of CD4+CD69+ t cells are observed. In case of CD4+CD25+ t cells 3.56% proliferation seen without activation and 29.01% cells are seen with activation. When cytokine secretions were analysed IL2 secretion was increased and downregulation was seen with IL4, IL17, IFN gamma.
We reported a rare case of oral carcinoma cuniculatum, a variant of oral squamous cell carcinoma that has bland cytomorphologic features, and a peculiar and characteristic growth pattern. Despite the lack of cytologic atypia, the tumour exhibited locally aggressive and infiltrative behaviour. And also, interestingly immunohistochemcical markers were analysed to further support the diagnosis.
Hemangiomatous ameloblastoma is a rare histopathological variant of ameloblastoma characterized by prominent vascular proliferation within the tumor stroma. It is often mistaken for primary vascular lesions, resulting in diagnostic difficulty and potential therapeutic challenges. We report a rare case of hemangiomatous ameloblastoma involving the mandible in a patient who presented with a progressively enlarging swelling. Radiographic examination revealed a well-defined expansile radiolucent lesion suggestive of an aggressive odontogenic tumor. Surgical excision was performed, and histopathological evaluation demonstrated typical ameloblastomatous epithelial islands interspersed with numerous dilated blood-filled spaces and proliferating vascular channels, confirming the diagnosis. Notably, infiltration into the adjacent soft tissues was identified, indicating its locally aggressive behaviour. Due to its rarity, limited literature exists regarding the biological behaviour and recurrence potential, mortality rate of this variant. This case underscores the critical role of histopathological examination in differentiating hemangiomatous ameloblastoma from other vascular and odontogenic lesions. Awareness of this entity is essential for accurate diagnosis, appropriate surgical management, and long-term follow-up to ensure public health and to reduce the risk of recurrence.
