Clinical reasoning is a core competency in standardized residency training for general practitioners, yet conventional case-based instruction is often constrained by limited clinical exposure, inconsistent case complexity, and insufficient opportunities for repeated decision-making practice. This study explores the application of computer-simulation-based clinical case training to improve clinical reasoning among general practice residents from a digital health communication perspective. A digital simulation environment was designed to present interactive clinical cases integrating patient history, symptoms, examination findings, laboratory results, and dynamic clinical feedback. Residents were required to collect information, identify clinical problems, formulate differential diagnoses, select appropriate examinations, and develop management plans through sequential decision-making processes. The digital platform also supported real-time feedback, standardized communication pathways, and repeated case-based learning, enabling trainees to review their reasoning processes and identify decision-making errors. The effectiveness of the training approach was evaluated by comparing clinical reasoning performance, diagnostic accuracy, decision-making efficiency, and learner engagement before and after the intervention. The findings indicate that computer-simulation-based clinical case training can provide a structured, interactive, and repeatable learning environment that supports the development of diagnostic and clinical decision-making abilities. From the perspective of digital health communication, the approach also facilitates more effective information exchange, feedback delivery, and interaction between learners and simulated clinical scenarios. This study suggests that computer-simulation-based training may serve as a valuable supplementary strategy for enhancing clinical reasoning and digital competency in standardized general practice residency training.
Due to the development of new media technologies, global dissemination of actual examples of intangible cultural heritage (ICH) has become easier and faster. Due to its diverse traditional arts and cultural practices, China presents a case showing how ICH is being preserved and disseminated via new technologies such as social media, virtual reality, and artificial intelligence. However, concerns of authenticity, commercialization, and elasticity, especially regarding access, are valid and persist. This study aimed to: (1) identify and critically analyze digital media strategies used in the global dissemination of ICH in China, (2) explore how digital media shapes audience reception and engagement with ICH across cultures, and (3) examine theoretical frameworks and methodologies used in existing literature. This research paper used a systematic literature review to collect information from Web of Science, Google Scholar and JSTOR. Twelve articles were included following the PRISMA guidelines, and a thematic analysis was conducted. Social media and other digital tools, such as VR, helped to improve the level of interaction and involvement of the audience. Nevertheless, cultural, sample, and algorithm biases were identified as risks. It emerged that both AI and holographic technologies are efficient tools for expanding the dissemination horizons internationally, and grounded theory and bibliometric analysis were identified as efficient approaches for creating dissemination frameworks. Digital media strategies offer promising solutions for ICH dissemination but require culturally sensitive approaches to protect authenticity and equitable access.
Museums hold a unique status in the cultural industry, playing the roles of both heritage repository and educational institutions and service providers to the community. Although the functions of internal organizational communication in museums are complex and numerous, the scholarly focus on internal organizational communication processes in museums is exceptionally small in comparison with the amount of literature devoted to the interaction with the external audience. This systematic literature review explores the research situation of organizational communication in museums, especially focusing on the public administration systems and management activities. In this review, 20 peer-reviewed articles and research reports (2015-2024) were analyzed using the PRISMA framework. The results indicate chronic communication failures that are marked with interdepartmental silos, lack of strategic-implementation, and poor leadership communication. The critical analysis reveals the structural, cultural, and political aspects of these challenges, as well as the disruptive quality of digital technologies and COVID-19 pandemic on the practices of museum communication. The study provides recommendations on investment in communication infrastructure, professional growth, governance reforms to improve organizational performance in museums.
Background: Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease characterized by aberrant Th17/Treg balance and autoantibody production. While glucocorticoids remain the cornerstone of treatment, their long-term adverse effects necessitate the development of steroid-sparing agents. The basic leucine zipper transcription factor ATF-like (BATF) serves as an essential pioneer factor for Th17 differentiation, yet its precise therapeutic potential in SLE remains underexplored. This study aims to validate the BATF/RORgt/IL-17 axis as a critical therapeutic target in SLE through integrative bioinformatics analysis of human cohorts and in vivo experimental validation using a combined regimen of Traditional Chinese Medicine (Langchuangding, LCD) and Prednisone. Methods: Transcriptomic profiles of peripheral blood mononuclear cells (PBMCs) from 61 SLE patients and 20 healthy controls (HC) were retrieved from the Gene Expression Omnibus (GEO: GSE50772). Differentially expressed genes (DEGs) and immune pathway signatures were analyzed. For in vivo validation, 40 female MRL/lpr mice (SLE model) and 10 normal Kunming mice were randomly divided into five groups. Over a 10-week intervention, body weight and organ indices were monitored. The mRNA and protein expression levels of BATF, RORgt (Rorc), and IL-17 in renal tissues were quantified using qPCR and ELISA. Serum autoantibodies (ANA, anti-dsDNA, anti-Sm-DNA) were also measured. Results: Bioinformatics analysis revealed significant upregulation of BCL6 and IL10 in SLE PBMCs, alongside a global interferon signature, establishing a pronounced systemic inflammatory state. In MRL/lpr mice, the Model group exhibited severe splenomegaly, elevated autoantibodies, and robust overexpression of renal BATF, RORgt, and IL-17. The Combined therapy (LCD + Prednisone) demonstrated superior efficacy, significantly attenuating body weight loss, normalizing spleen indices, and drastically suppressing the BATF/RORgt/IL-17 cascade at both transcriptional and translational levels (p < 0.001 vs. Model). Serum ANA, anti-dsDNA, and anti-Sm-DNA levels were also maximally reduced in the Combined group. Conclusion: The BATF/RORgt/IL-17 axis is a pivotal pathogenic driver in SLE, bridging epigenetic chromatin remodeling with downstream Th17-mediated autoimmunity. The synergistic application of LCD and Prednisone effectively dismantles this axis, offering a promising steroid-sparing, individualized therapeutic strategy for SLE management.
Millions of people worldwide live with opioid use disorder (OUD). Family members of people living with OUD may decide to provide or deny emotional support, and these choices have important implications for the well-being of individuals with OUD. This study investigated the impact of family emotional support, or lack thereof, on people’ s ability to reduce their drug use and pursue sobriety. This study uses systematic review, a method that allows for the systematic collection of articles about a particular topic, even when they have diverse disciplinary backgrounds and methodologies. Eighteen studies about the impact of emotional support from family members on drug use reduction were identified from MEDLINE and Sociology Abstracts primarily, as well as Directory of Open Access Journals, ProQuest Social Sciences, and Toxicology Abstracts. These articles were then synthesized into four outcome categories: treatment adherence and retention, sobriety and abstinence, treatment seeking, and recovery. Across the studies, family emotional support was generally beneficial for reducing drug use, although people living with OUD sometimes grappled with complex feelings of guilt or pressure in their supportive interactions with family members. Strengths, limitations, and future directions for studies about family emotional support in the context of OUD are discussed.
