ABSTRACT This study aims to explore the role of microRNAs as potential biomarkers and molecular regulators in Orthodontic Tooth Movement. A comprehensive review of current literature was conducted, focusing on studies that investigate the expression and function of specific miRNAs in relation to orthodontic treatment. The review included data on miRNAs detected in oral fluids and their association with key molecular pathways, such as osteoclastogenesis and osteogenesis, involved in Orthodontic Tooth Movement. The findings indicate that miRNAs such as miR-21, miR-27, and miR-155-5p play significant roles in regulating gene expression that impacts bone remodeling and tooth movement. Additionally, miRNAs like miR-29 and miR-34a were found to influence the balance between osteoclast and osteoblast activity, potentially accelerating or modulating the rate of Orthodontic Tooth Movement. miRNAs not only hold promise as biomarkers for monitoring treatment progress and effectiveness in orthodontics but also as potential therapeutic targets for future drug development. Their ability to regulate key molecular processes in Orthodontic Tooth Movement may revolutionize orthodontic treatment, enabling a transition from purely mechanical approaches to molecular ones.
ABSTRACT Menopause constitutes a physiological transition marked by significant hormonal fluctuations that substantially affect bone metabolism and may influence the predictability and outcomes of dental interventions, particularly implant therapy. This integrative review aims to critically examine the relationship between menopausal status and bone quality, alongside its implications for implant osseointegration. A systematic search of the PubMed, SciELO, Lilacs, and Scopus databases was conducted to retrieve studies published between 2015 and 2025. Studies investigating menopause, osteoporosis, bone metabolism, and dental implants were selected following rigorously defined inclusion and exclusion criteria. The cumulative evidence indicates that although menopause is associated with a decline in bone mineral density, implant-supported rehabilitation can achieve reliable and successful outcomes when treatments are predicated upon individualized treatment planning, comprehensive systemic evaluation, precise surgical execution, and coordinated interdisciplinary management. Thus, current evidence refutes the notion of menopause as an absolute contraindication for dental implant therapy. Instead, it advocates for meticulous systemic assessment and the adoption of tailored therapeutic strategies to enhance osseointegration and secure long-term implant success.
RESUMO Objetivo avaliar a influência da administração sistêmica de melatonina na perda óssea alveolar, em periodontite induzida em ratas. Métodos 10 ratas foram aleatoriamente divididas em dois grupos (n=5): grupo teste – animais que receberam administração intraperitoneal diária de 50 mg/kg de melatonina, por 30 dias; e grupo controle – animais que receberam administração de solução fisiológica por 30 dias. Todos os animais tiveram seus primeiros molares do lado esquerdo submetidos à colocação de uma ligadura (fio de seda) para o desenvolvimento da doença periodontal, em um delineamento de boca-dividida. Após 30 dias os animais foram eutanasiados e as mandíbulas coletadas e processadas para posterior análise morfométrica. Resultados Após a análise dos dados (α=5%), pode-se observar maiores valores de perda óssea nos molares com a ligadura, quando comparados aos do lado oposto, que não receberam a ligadura (p<0,05). Comparando os grupos (com e sem melatonina), os resultados demonstraram que houve uma perda óssea menor no grupo de ratas que receberam a administração de MLT (p<0,05). Conclusão a administração de 50 mg/kg de melatonina intraperitoneal resultou em uma diminuição na perda óssea periodontal em ratas com periodontite induzida.
ABSTRACT Objective: This cross-sectional study aimed to investigate knowledge and beliefs about oral health among mothers of children and adolescents. Methods: A semi-structured questionnaire was applied to mothers (n=210) of children and adolescents attending dental school clinics at a public university. The variables studied were socioeconomic, reported oral morbidity, use of services, knowledge about oral health, self-perception of oral health, personal beliefs, and values. The data were analyzed descriptively and using multiple logistic regression, with the following outcomes: knowledge and beliefs in oral health, adopting a significance level of 5%. Results: The average number of correct answers on oral health knowledge in the questionnaire was 16.9 (maximum correct answers=20), and on oral health beliefs was 5.3 (maximum correct answers=9). Mothers with higher education are twice as likely to have more accurate answers on oral health knowledge questions (OR=2.18; 95% CI: 1.12-4.27; p<0.05) and on belief questions in oral health (OR=2.38; 95%CI: 1.20-4.72; p<0.05). Conclusion: In conclusion, the mothers in the present study demonstrated, in general, satisfactory knowledge of issues related to oral health and a reasonable understanding of limiting beliefs, with a significant association with education. There are still learning gaps about specific beliefs and knowledge that must be addressed.
ABSTRACT Monochromatic resins stand out due to their chameleon effect, which allows the material to blend with the surrounding tooth structure, providing an aesthetic restoration with a simplified restorative technique. This type of resin eliminates the need for shade selection and the use of multiple materials, thereby reducing chair time during dental appointments. Thus, this study aims to present a simplified strategy for restoring Non-Carious Cervical Lesions greater than 1 mm in depth using monochromatic resins. For this purpose, the use of gingival retraction cord for isolation and proper moisture control is recommended to ensure success in the adhesive procedure. Selective enamel etching, combined with self-etch adhesive systems, is considered a successful option for the restoration of Non-Carious Cervical Lesions. The restoration should be performed using the oblique incremental technique, followed by light curing for the time recommended by the manufacturer. Finishing and polishing should be carried out using flexible discs to achieve optimal results. The use of monochromatic resins may be indicated for the restoration of Non-Carious Cervical Lesions, since their chameleon-like properties provide effective mimicry of the natural tooth color. The final outcome depends on the cavity size and the favorable color of the substrate. Therefore, the indication for monochromatic resins must take into account the specific details and etiological factors of each individual case.
