Chondrogenic tumors represent the most common group of primary bone neoplasms and may also occur in soft tissue. They encompass a wide spectrum of benign, locally aggressive, and malignant lesions. Histologically, they share the presence of cartilaginous matrix, which may be present in variable amounts. Chondrogenic tumors often show characteristic features on imaging studies, and correlation with radiologic findings is critical, particularly in lesions arising in bone. The term chondroid is often used to refer to both tumors with “true” cartilage matrix and those with cartilage-like stroma, which can introduce some confusion. A number of recurrent molecular alterations helpful for diagnosis have been identified across a range of benign and malignant cartilaginous and chondroid tumors. This review provides a practical approach to chondrogenic and chondroid neoplasia in the bones and soft tissue, emphasizing key clinical, radiologic, histologic, and molecular features and highlighting recently described entities.
The macroscopic handling of mandibular resection specimens for odontogenic tumors presents a distinct set of challenges and considerations that differentiate it from the examination of mandible specimens resected for oral squamous cell carcinoma, osteoradionecrosis, metastases or primary bone sarcoma. The following outlines the background considerations and operational methodology around mandibular resection specimens performed in the treatment of odontogenic tumors. This manuscript is intended as the initial step in process alignment rather than a disease-specific review. This work highlights the importance of unique considerations within grossing strategies and provides a framework for practice in this area of head and neck pathology.
Bone and soft tissue pathology - perhaps more than in any other surgical pathology subspecialty - has been profoundly shaped by a cadre of trailblazing female pathologists who have seamlessly integrated morphologic expertise, molecular innovation, and educational leadership. While no single review can capture the full breadth of contributions made by women in this field, this article highlights the remarkable achievements of six such leaders - Drs. Sharon W. Weiss, Adrienne M. Flanagan, Julia A. Bridge, Cristina R. Antonescu, Judith V.M.G. Bovée, and Jeanne M. Meis - whose careers collectively mirror the evolution of musculoskeletal pathology from morphology-centered diagnoses to an era of integrative molecular precision. Through their work, we trace a historical journey encompassing seminal tumor descriptions, transformative advances in immunohistochemistry and molecular cytogenetics, and parallel improvements in classification and clinical management.
