The theory of the evolutionary role of hereditary tumors, or carcino-evo-devo theory, may be considered as the next step after A.N. Severtsov’s theory of phylembryogenesis, the theory of evo-devo, and Susumu Ohno’s theory of evolution by gene duplication. The carcino-evo-devo theory pretends to be a unifying biological theory, because it unifies within an integrated consideration three main types of biological development—individual, evolutionary, and neoplastic development. The carcino-evo-devo theory explains a series of unexplained biological phenomena. In the first place, it explains the mechanisms of progressive evolution and biological complexity increase using the concept of relatively unstable transitory forms and autonomous uncontrolled processes. The theory of the evolutionary role of hereditary tumors has formulated several nontrivial predictions in various fields of biology, which have been confirmed in the lab of the author and in other laboratories. The consequences of the carcino-evo-devo theory have implications in medicine and biotechnology. The first part of this article describes the basic principles from which the main hypothesis followed, the progressive developments of the concept, and the first experimental data in support of nontrivial predictions obtained in the laboratory of the author in the period before 2014, when our monograph Evolution by Tumor Neofunctionalization (Kozlov, 2014) was published.
Everyone has the right to the highest attainable standard of health, and modern preventive, preventive, and rehabilitative manipulations promote health and well-being. Due to a number of fundamental projects on the study of human health at various levels (genomic, proteomic, and metabolomic), and molecular mechanisms of the development of pathological conditions, there has been a great leap in the field of applied sectors of industrial biotechnology, including segments of the pharmaceutical and food industries, significantly improved health-saving resources, and improved quality of life of the population. This article will review the advanced achievements of fundamental and applied research, as well as promising areas of the bioindustry.
Since the dawn of humanity, human beings have inherently sought a state of security, trying to make their existence as comfortable as possible. Accordingly, among the many factors affecting human health, comfort and well-being, the quality of the micro-environment and ecology, as well as the health care system and health-preserving resources, are important. In this regard, environmental security, with its systemic nature, brings a significant contribution to the PPM model by optimizing the state of balance in the interrelationship of natural, anthropogenic, physiological, and social processes. Accordingly, individualized nutrition and pharmacointervention for preventive and prophylactic purposes, as important tools for health preservation, represent an integrative approach aimed at understanding the interaction between nutrition and the environment within the formed or formed lifestyle. This review will consider the main components of human health protection, as well as their impact on the preservation of ecobiocenosis stability.
The morphogenetic properties of a collagen gel prepared by acetic acid extraction from the tendon sheaths (peritenons) of the paravertebral tendons of Wistar rats were studied. The gel was used as a substrate during in vitro cultivation together with mesenchymal stromal cells for 14 days in growth and osteogenic incubation media. It has been established that the collagen framework of the peritenon substrate is strengthened by increasing the connectivity of fibrillar nodes and is structured with the formation of lamellar and tangle formations. Sesamoid globules, penetrating into the substrate from the initial peritenon gel, remain inert during cultivation in the growth medium, but exhibit an increased ability to structure calcium phosphates in the osteogenic medium. The formation of cell-mediated structures occurs by directions of fibro, tendo-, ligament-, and osteogenic differentiation. The fibrogenic direction provides a structuring framework; the tenogenic direction provides the formation of embryonic tendons according to the mechanism of lateral assembly of collagen subfibrils on cell surfaces and their autonomization in the form of tendon filament primordia; the ligamentogenic direction provides structuring of collagen ribbons associated with tangles and elastic fibers; and the osteogenic direction provides the formation of lamellar, trabecular and nodular osteoid structures through intramembranous ossification, accompanied by activation of alkaline phosphatase and mineralization. The formation of enthesis predictors is the organization of commissures between mechanically different-phase components of osteoid structures and frame. A classification of taxonomic forms has been developed and a hypothesis has been proposed about the role of evolutionary tools in the structuring of the collagen framework in tissue cultures in vitro. A classification of taxonomic forms has been developed and a hypothesis has been proposed about the role of evolutionary tools in the structuring of the collagen framework in tissue cultures in vitro.
This article discusses the issues of conservation, distribution, and acclimatization of sika deer on the territory of the Russian Federation, the Central Federal District and of the National Park State Complex Zavidovo. A detailed analysis of the condition of the first range of sika deer in the Primorsky krai is given, as well as the history of settlement and dynamics of its population in the Russian Federation. For the regions of the Central Federal District, the results of the cadastral assessment of sika deer resources were calculated, including the average long-term number, the average long-term population density (animals) per 1000 hectares of characteristic lands, and the average long-term cost of resources (million rubles). As an effective model for the acclimatization of sika deer, the experience of its economic use was carried out in the Zavidovo National Park State Complex (Tver region).
