Objective To explore the efficacy of guizhi shaoyao zhimu decoction in acute attack of gouty arthritis.Methods 80 cases of acute gouty arthritis patients admitted to our hospital from January 2020 to December 2021 were selected as the research object,and were divided into the control group and the observation group by random number table method,40 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with guizhi shaoyao zhimu decoction plus or minus treatment.The clinical efficacy,symptoms and signs,erythrocyte sedimentation rate(ESR),C-reactive protein and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in joint swelling socre,ESR and C-reactive protein between the two groups(P>0.05).After treatment,joint swelling score,ESR and C-reactive protein levels in 2 groups were lower than before,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Guizhi shaoyao zhimu decoction is effective in the treatment of acute gouty arthritis,and can promote the improvement of symptoms and signs of patients,with less adverse reactions and high safety,which is worthy of extensive clinical promotion and application.
Objective To investigate factors associated with change in total hip bone mineral density(THBMD)after zoledronic acid(5mg)infusion in elderly osteoporosis(OP)women.Methods A total of 122 elderly OP women were recruited into the study,their THBMD,bone metabolism markers and blood biochemistry were tested,and THBMD was reviewed 12 months after receiving zoledronic acid(5mg).Multiple regression analysis was applied to screen for independent associated factors of △THBMD.Results Serum C-terminal cross-linking telopeptide of type 1 collagen(CTX,β=0.031,P<0.01)and body mass index(BMI,β=0.001,P<0.05)were independent factors associated with △THBMD in elderly osteoporosis women.Conclusion The △THBMD after zoledronic acid infusion in elderly osteoporosis women is affected by multiple factors,and the patients with higher serum CTX and BMI have a higher △THBMD.
Objective To investigate the current status of stress urinary incontinence among middle-aged and elderly women in Hangzhou,and analyze the influencing factors.Methods From June 2021 to May 2022,a convenience sampling method was used to select 625 middle-aged and elderly women>45 years old in 16 communities in Hangzhou city to conduct a questionnaire survey to learn about their underlying diseases,stress urinary incontinence,medical consultation,and quality of life,and to analyze their influencing factors.Results The prevalence of stress urinary incontinence among middle-aged and elderly women in Hangzhou was 24.96%,and the consultation rate was 24.36%.Logistic regression analysis revealed that age,education,constipation,chronic respiratory disease,and the number of pregnancies were the risk factors for stress urinary incontinence in middle-aged and elderly women(P<0.05).Quality of life rating analysis showed that middle-aged and elderly women with stress urinary incontinence had higher scores in somatic function,social function,somatic pain,energy,and mental health than middle-aged and elderly women without stress urinary incontinence,and the difference was statistically significant(P<0.05).Conclusion Middle-aged and elderly women have a higher prevalence of stress urinary incontinence,a lower rate of consultation,and a lower quality of survival than middle-aged and elderly women who do not have stress urinary incontinence.Therefore,middle-aged and older women should be screened early and provided with targeted educational guidance and intervention.
近些年,越来越多的研究在乳腺领域取得了突破性进展,但乳腺癌(breast cancer,BC)全球发病率仍在上升,已成为导致女性疾病负担的主要癌症.三阴性乳腺癌(triple-negative breast cancer,TNBC)是目前乳腺癌分子分型中最具侵袭力的类型,其异质性高、预后差,在我国乳腺癌综合治疗及预后因素分析中尚具挑战.
Objective To explore the impacts of plasma 8-hydroxydeoxyguanosine(8-OHDG)and plasma malondialdehyde(MDA)on coronary arteries lesions(CAL)and vascular endothelial dysfunction in children with Kawasaki disease(KD).Methods The plasma 8-OHDG and plasma MDA were measured in KD children group at acute stage(n=60,12 cases had coronary artery lesions,48 coronary were normal),paracmastic and recovery stage(both 40 cases)by ELISA method.Measurement of vasodilator response(FMD%)mediated by brachial artery flow in paracmastic and recovery stage KD children group.Another 15 febrile children(the febrile group)and 15 healthy children(the control group)were selected.Results The plasma 8-OHDG and plasma MDA concentrations in acute and paracmastic and recovery stage of KD children group were all higher than those of normal control group(P<0.05).Plasma 8-OHDG and plasma MDA concentrations in acute stage were significandy higher than those of KD children group in paracmastic and recovery stage and the fever patients group(P<0.05).The CALs patients had higer plasma 8-OHDG and plasma MDA concentrations than the NCALs patients(P<0.05).Using plasma 8-OHDG concentration≥1.241 ng/mL,MDA concentration≥0.456nmol/mL as cut-off values for diagnosing CALs respectively,the areas under the ROC curves were 0.899 and 0.748,the sensitivity were 83.3%and 100%,the specificity were 91.7%and 39.6%,respectively.FMD of the brachial artery was significantly lower in both of KD children in paracmastic and recovery stage than that in the control group(P<0.05).KD children in paracmastic stage had lower FMD of the brachial artery than that in recovery stage group.The FMD of the brachial artery with KD children in paracmastic and recovery stage were negatively correlated with the plasma level of 8-OHDG and plasma MDA(r=-0.495,-0.357,P<0.05).Conclusion Oxidative stress maybe involve from the acute stage to the recovery stage with KD children.8-OHDG appears to be better in the diagnosis of coronary artery lesions than MDA.There are vascular endothelial dysfunction during the paracmastic and recovery stage with KD children.Increasing plasma 8-OHDG and MDA concentrations may impair the vascular endothelial function.
