Влияние Периндоприла На Ремоделирование Левого Желудочка И Цереброваскулярную Реактивность У Больных Артериальной Гипертензией С Кальцинозом Аортального Клапана

To assess the to assess the safety of goal blood pressure (GBP) destination and the influence on left ventricular (LV) remodeling and cerebral vascular reactivity (CVR) 30 patients with arterial hypertension (AH) and calcific aortic valve (CAV) were prescribed perindopril (8 mg) based therapy for 3 months. LV geometry, diastolic function (DF), LV-aorta pressure gradient, AV density and CVR parameters were measured by ultrasound methods before and after treatment. After the treatment the reversal of LV remodeling and improvement of LVDF were noted. Decrease in LV-aorta pressure gradient and AV ultrasonic density was not significant. Destination of GBP on P based therapy, was accompanied by improvement of CVR in majority of patients, except for 2 patients with significant stenosis (Gmax ≥ 36 mm Hg and AV ultrasound density ≥ 18 units). Conclusions. In majority of patients with CAV antihypertensive therapy based on P promotes achievement of goal BP and reversal of LV remodeling without deterioration of cerebral blood flow, for acception of patients with significant AV stenosis.