The combined treatment results of 122 pediatric (5–17 years) osteosarcoma patients receiving therapy in N.N.Petrov Oncology Research Institute in 1980–2010 were analyzed. Among the patients, 72,6% had localized form and 27,4% had metastatic disease. The median follow-up was 63,2 (13–378) months. Treatment results correlated with process dissemination, chemotherapy regimen and surgical procedure used. The best results were achieved in patients receiving organ-sparing surgery, which can be performed in, approximately, 80% of the patients.