The aim of the research. To study the quantitative indicators, parameters of phagocytic activity and chemiluminescence response of peripheral blood neutrophils in patients with muscle-invasive bladder cancer before surgical treatment. Materials and methods. The study involved 44 patients with muscle-invasive bladder cancer at the age of 45-55 years old. Control group was consisted of 39 healthy donors. To determine the phagocytic index and phagocytic number were carried out the tests with latex particles and S. epidermidis culture. The assessment of luminol dependent chemiluminescence (ChL) of neutrophils was carried out by the method De Sole et al. (1983). Results. In patients with muscle-invasive bladder cancer was detected the increase of percentage and absolute number of neutrophils in the peripheral blood, were found phagocytic activity changes and the chemiluminescent response. Conclusion. The observed changes reflect the functional-metabolic stress of neutrophilic granulocytes in patients with muscle-invasive bladder cancer.
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