The purpose of this study was to improve treatment outcomes in inoperable soft-tissue sarcomas using preoperative thermoradiotherapy and thermoradiochemotherapy. 175 patients with inoperable soft-tissue sarcomas were divided into 3 groups: Group 1 (57 patients) received preoperative radiotherapy, Group 2 (102 patients) received thermoradiotherapy and Group 3 (16 patients) received thermoradiochemotherapy. Radiotherapy was given by split doses. Irradiation was given at 4 or 5 Gy 2 or 3 times a week to a total tumor dose 30-32 Gy. Local electromagnetic hyperthermia was performed using «Yakhta» apparatus at 915; 460 and 40 MHz. Heating was given 2 times weekly for 60 min. Tumor temperature was maintained at 41-45°C. Group 3 patients (thermoradiochemotherapy) received intra-arterial adriamycin and cisplatin chemotherapy at 3-4 days before thermoradiotherapy. Complete tumor response or a more than 50% tumor regression were achieved in 76 (74,5%) patients from Group 2 and in 13 (81,3%) patients from Group 3, cf. with only 14 (24,6%) patients from Group 1 (p0,05). Local hyperthermia in combination with preoperative radioand radiochemotherapy increases significantly complete and partial response in soft-tissue sarcomas.
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