The article gives the characteristics of the current state of the problem legionellosis, features of pathogen ecology and features of the epidemiology of legionellosis. There is insufficient knowledge about the epidemiological features of infection in health care and implementation of epidemiological surveillance. Shows the results of epidemiological studies on the legionellosis in the Nizhny Novgorod region: there is a representation of Legionella pneumophila in the etiology of community-acquired and nosocomial pneumonia, the level of contamination and colonization of various departments in medical institutions. Studied the sensitivity of the Legionella pneumophila to disinfectants. High risk objects of colonization and the most likely reservoirs for L.pneumophila in medical institutions are detected. Identified three types of hospital departments, depending on the probability of infection in patients and the possibility of admission of patients with Legionella infection. Proposed parameters of epidemiological and microbiological surveillance system for monitoring and control with a differentiated approach depending on the type of departments. Developed approaches to improve epidemiological surveillance and control of Legionella infection in the Nizhny Novgorod region.