Дозозависимые Противовоспалительные, Эндотелиопротективные, Кардиопротективные Эффекты Аторвастатина

Research of anti-inflammatory, endothelioprotective, cardioprotective activity of inhibitor of 3-gidroksi-3-metilglutaril-CoA reductase atorvastatin in experiments on mice and rats was carried out. The received results have allowed to establish the presence of expressed dosagedependent anti-inflammatory activity of atorvastatin. The expressed correction of endothelial dysfunction at application of atorvastatin in a dose of 2.2 mg/kg is evident Thus application of atorvastatin in a dose of 8.6 mg/kg has not led to authentically more expressed decreasing of endothelial dysfunction, in comparison with a dose of 2.2 mg/kg. At carrying out of loading tests it is established the expressed cardioprotective activity of atorvastatin in a dose of 2.2 mg/kg.