New data on the distribution of some alien taxa in Moscow, Ryazan, Saratov, Samara and Tambov regions is presented, along with the discussion of the ecology and distribution pattern of several neophytes in the European Russia. New records of alien plants are presented for Ryazan (Amaranthus powellii (Amaranthaceae), Glycyrrhiza glabra (Fabaceae)), Samara (Eriochloa villosa (Poaceae)), Tambov (Echinochloa muricata (E. microstachya), Eriochloa villosa (Poaceae), Helianthus lenticularis (Asteraceae)) and Moscow regions (Rumex patientia (Polygonaceae)). It was discovered that R. patientia is the most common species of the genus in the Saratov region eastward of the Volga River, where R. confertus, which is prevailing in the western part of the region, becomes rare. Echinochloa muricata and Eriochloa villosa are encountered more and more often, which may indicate that these grasses are progressively naturalizing in the European Russia.